GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | A | 122 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | A | 122 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 122 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Ionic | ICL2 | K | 133 | 34x57 | G.H5 | D | 377 | G.H5.22 |
Polar | ICL2 | K | 133 | 34x57 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | ICL2 | K | 133 | 34x57 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | ICL2 | K | 133 | 34x57 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | H8 | Y | 303 | 8x60 | G.h4s6 | K | 344 | G.h4s6.19 |
Polar | C-term | Y | 306 | - | G.H4 | D | 336 | G.H4.16 |
Hydrophobic | C-term | Y | 306 | - | G.H4 | D | 336 | G.H4.16 |
Van-der-waals | C-term | Y | 306 | - | G.H4 | D | 336 | G.H4.16 |
Polar | ICL2 | K | 127 | 34x51 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | K | 127 | 34x51 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | K | 127 | 34x51 | G.hns1 | R | 56 | G.hns1.03 |
Polar | H8 | F | 293 | 8x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | M | 310 | - | G.h4s6 | K | 338 | G.h4s6.01 |
Hydrophobic | TM3 | I | 123 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | H8 | A | 295 | 8x52 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | A | 295 | 8x52 | G.H5 | Q | 381 | G.H5.26 |
Polar | H8 | S | 299 | 8x56 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | H8 | S | 299 | 8x56 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | H8 | S | 299 | 8x56 | G.h4s6 | S | 343 | G.h4s6.12 |
Polar | ICL2 | K | 127 | 34x51 | G.s2s3 | K | 219 | G.s2s3.01 |
Hydrophobic | ICL2 | K | 127 | 34x51 | G.s2s3 | K | 219 | G.s2s3.01 |
Van-der-waals | ICL2 | K | 127 | 34x51 | G.s2s3 | K | 219 | G.s2s3.01 |
Polar | H8 | R | 296 | 8x53 | G.h3s5 | N | 288 | G.h3s5.02 |
Hydrophobic | H8 | R | 296 | 8x53 | G.h3s5 | N | 288 | G.h3s5.02 |
Van-der-waals | H8 | R | 296 | 8x53 | G.h3s5 | N | 288 | G.h3s5.02 |
Polar | H8 | S | 299 | 8x56 | G.h4s6 | K | 344 | G.h4s6.19 |
Hydrophobic | H8 | S | 299 | 8x56 | G.h4s6 | K | 344 | G.h4s6.19 |
Van-der-waals | H8 | S | 299 | 8x56 | G.h4s6 | K | 344 | G.h4s6.19 |
Polar | H8 | Y | 303 | 8x60 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | H8 | Y | 303 | 8x60 | G.h4s6 | S | 343 | G.h4s6.12 |
Ionic | ICL2 | E | 131 | 34x55 | G.HN | R | 52 | G.HN.52 |
Polar | ICL2 | E | 131 | 34x55 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | ICL2 | E | 131 | 34x55 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | ICL2 | E | 131 | 34x55 | G.HN | R | 52 | G.HN.52 |
Polar | ICL2 | K | 130 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | K | 130 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | K | 130 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Polar | H8 | R | 296 | 8x53 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | H8 | R | 296 | 8x53 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | R | 296 | 8x53 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | C-term | Y | 306 | - | G.h4s6 | N | 341 | G.h4s6.10 |
Van-der-waals | C-term | Y | 306 | - | G.h4s6 | N | 341 | G.h4s6.10 |
Hydrophobic | TM7 | I | 288 | 7x55 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM7 | I | 288 | 7x55 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM6 | L | 222 | 6x25 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL3 | T | 219 | - | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | ICL3 | T | 219 | - | G.H5 | L | 371 | G.H5.16 |
Polar | H8 | Q | 292 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | Q | 292 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | Q | 292 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM2 | V | 57 | 2x39 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM2 | V | 57 | 2x39 | G.H5 | D | 377 | G.H5.22 |
Polar | H8 | M | 301 | 8x58 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | C-term | M | 310 | - | G.H4 | R | 337 | G.H4.17 |
Van-der-waals | C-term | M | 310 | - | G.H4 | R | 337 | G.H4.17 |
Polar | TM7 | V | 289 | 7x56 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM7 | V | 289 | 7x56 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM7 | V | 289 | 7x56 | G.H5 | M | 379 | G.H5.24 |
Ionic | H8 | R | 296 | 8x53 | G.H5 | E | 373 | G.H5.18 |
Polar | H8 | R | 296 | 8x53 | G.H5 | E | 373 | G.H5.18 |
Polar | C-term | L | 307 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Hydrophobic | C-term | L | 307 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Van-der-waals | C-term | L | 307 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Hydrophobic | H8 | Y | 303 | 8x60 | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | H8 | Y | 303 | 8x60 | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | TM3 | R | 119 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | R | 119 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Polar | H8 | Y | 303 | 8x60 | G.h4s6 | N | 341 | G.h4s6.10 |
Hydrophobic | H8 | Y | 303 | 8x60 | G.h4s6 | N | 341 | G.h4s6.10 |
Van-der-waals | H8 | Y | 303 | 8x60 | G.h4s6 | N | 341 | G.h4s6.10 |
Polar | C-term | S | 309 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | C-term | S | 309 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Polar | TM4 | N | 134 | 4x38 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM4 | N | 134 | 4x38 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | TM4 | N | 134 | 4x38 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | H8 | R | 296 | 8x53 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | TM6 | V | 226 | 6x29 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | V | 226 | 6x29 | G.H5 | L | 375 | G.H5.20 |
Polar | H8 | L | 302 | 8x59 | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | H8 | L | 302 | 8x59 | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | H8 | L | 302 | 8x59 | G.h4s6 | R | 342 | G.h4s6.11 |
Polar | C-term | Y | 306 | - | G.H4 | R | 337 | G.H4.17 |
Hydrophobic | C-term | Y | 306 | - | G.H4 | R | 337 | G.H4.17 |
Van-der-waals | C-term | Y | 306 | - | G.H4 | R | 337 | G.H4.17 |
Polar | H8 | Q | 292 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | H8 | Q | 292 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | Q | 292 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM2 | T | 55 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | ICL2 | K | 127 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | K | 127 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM3 | I | 123 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | I | 123 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Polar | ICL3 | R | 218 | - | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL3 | R | 218 | - | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM7 | L | 285 | 7x52 | G.H5 | L | 380 | G.H5.25 |
Ionic | ICL2 | E | 131 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Polar | ICL2 | E | 131 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | E | 131 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | E | 131 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | C-term | Y | 306 | - | G.h4s6 | R | 339 | G.h4s6.08 |
Van-der-waals | C-term | Y | 306 | - | G.h4s6 | R | 339 | G.h4s6.08 |
Hydrophobic | TM2 | V | 57 | 2x39 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | V | 57 | 2x39 | G.H5 | L | 380 | G.H5.25 |
Polar | H8 | I | 298 | 8x55 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | H8 | I | 298 | 8x55 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | H8 | I | 298 | 8x55 | G.h4s6 | S | 343 | G.h4s6.12 |
Polar | C-term | Y | 306 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Aromatic | C-term | Y | 306 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | C-term | Y | 306 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | C-term | Y | 306 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | TM7 | V | 289 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | V | 289 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Aromatic | ICL2 | Y | 128 | 34x52 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | Y | 128 | 34x52 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | Y | 128 | 34x52 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM6 | L | 222 | 6x25 | G.H5 | L | 371 | G.H5.16 |
Polar | H8 | Q | 292 | 8x49 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | H8 | Q | 292 | 8x49 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | H8 | Q | 292 | 8x49 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL2 | K | 133 | 34x57 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | K | 133 | 34x57 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | K | 133 | 34x57 | G.hns1 | R | 55 | G.hns1.02 |
Polar | ICL2 | K | 130 | 34x54 | G.S1 | L | 57 | G.S1.01 |
Van-der-waals | ICL2 | K | 130 | 34x54 | G.S1 | L | 57 | G.S1.01 |
Hydrophobic | H8 | V | 300 | 8x57 | G.h3s5 | F | 287 | G.h3s5.01 |
Van-der-waals | H8 | V | 300 | 8x57 | G.h3s5 | F | 287 | G.h3s5.01 |
Polar | H8 | Q | 292 | 8x49 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | H8 | Q | 292 | 8x49 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | H8 | Q | 292 | 8x49 | G.H5 | K | 376 | G.H5.21 |
Polar | H8 | V | 300 | 8x57 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | H8 | Y | 303 | 8x60 | G.h4s6 | R | 340 | G.h4s6.09 |
Van-der-waals | H8 | Y | 303 | 8x60 | G.h4s6 | R | 340 | G.h4s6.09 |
Polar | ICL2 | K | 127 | 34x51 | G.s2s3 | K | 220 | G.s2s3.02 |
Hydrophobic | ICL2 | K | 127 | 34x51 | G.s2s3 | K | 220 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 127 | 34x51 | G.s2s3 | K | 220 | G.s2s3.02 |
Polar | ICL1 | K | 52 | - | G.H3 | K | 284 | G.H3.16 |
Polar | H8 | L | 302 | 8x59 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | H8 | L | 302 | 8x59 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | H8 | L | 302 | 8x59 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | H8 | Y | 303 | 8x60 | G.h3s5 | F | 287 | G.h3s5.01 |
Polar | ICL2 | K | 130 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | K | 130 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | K | 130 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM6 | L | 222 | 6x25 | G.H5 | L | 375 | G.H5.20 |
Polar | ICL2 | E | 131 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | E | 131 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | E | 131 | 34x55 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM6 | V | 226 | 6x29 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM6 | K | 221 | 6x24 | G.H5 | H | 364 | G.H5.09 |
Van-der-waals | TM6 | K | 221 | 6x24 | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | TM6 | I | 233 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM6 | S | 230 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | S | 230 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | H8 | F | 293 | 8x50 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | F | 293 | 8x50 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM3 | A | 122 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | A | 122 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | Y | 306 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Van-der-waals | C-term | Y | 306 | - | G.h4s6 | R | 340 | G.h4s6.09 |
Polar | TM3 | R | 119 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 119 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 119 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Polar | H8 | Q | 292 | 8x49 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | H8 | Q | 292 | 8x49 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | H8 | Q | 292 | 8x49 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM2 | M | 61 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | M | 61 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | M | 310 | - | G.h4s6 | R | 339 | G.h4s6.08 |
Van-der-waals | C-term | M | 310 | - | G.h4s6 | R | 339 | G.h4s6.08 |