GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | A | 129 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM7 | Y | 287 | 7x54 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | Y | 287 | 7x54 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL2 | K | 133 | 34x57 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | K | 133 | 34x57 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | K | 133 | 34x57 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | K | 130 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Aromatic | ICL2 | K | 130 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | K | 130 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | K | 130 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | H8 | Q | 292 | 8x49 | G.H5 | Q | 390 | G.H5.22 |
Polar | TM6 | K | 229 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | K | 229 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | K | 229 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | I | 234 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Polar | TM3 | R | 119 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 119 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 119 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM6 | K | 223 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | K | 223 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Ionic | H8 | R | 296 | 8x53 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | L | 222 | 6x25 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | L | 222 | 6x25 | G.H5 | R | 385 | G.H5.17 |
Polar | ICL2 | K | 127 | 34x51 | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | ICL2 | K | 127 | 34x51 | G.s2s3 | D | 215 | G.s2s3.01 |
Polar | TM6 | K | 221 | 6x24 | G.H5 | N | 377 | G.H5.09 |
Hydrophobic | TM6 | K | 221 | 6x24 | G.H5 | N | 377 | G.H5.09 |
Van-der-waals | TM6 | K | 221 | 6x24 | G.H5 | N | 377 | G.H5.09 |
Hydrophobic | ICL2 | K | 127 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | K | 127 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | H8 | Q | 292 | 8x49 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | H8 | Q | 292 | 8x49 | G.H5 | R | 389 | G.H5.21 |
Polar | ICL2 | K | 130 | 34x54 | G.S1 | T | 40 | G.S1.01 |
Van-der-waals | ICL2 | K | 130 | 34x54 | G.S1 | T | 40 | G.S1.01 |
Polar | H8 | S | 290 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | S | 290 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | S | 290 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL2 | K | 133 | 34x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | K | 133 | 34x57 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | K | 133 | 34x57 | G.H5 | H | 387 | G.H5.19 |
Polar | TM3 | D | 118 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | D | 118 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | D | 118 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | I | 123 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | I | 123 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | L | 222 | 6x25 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | L | 214 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Polar | ICL3 | T | 219 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL3 | T | 219 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL3 | T | 219 | - | G.H5 | Q | 384 | G.H5.16 |
Polar | TM2 | T | 56 | 2x38 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | H8 | F | 293 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | F | 293 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | P | 126 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Polar | ICL2 | K | 133 | 34x57 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ICL2 | K | 133 | 34x57 | G.H5 | Q | 390 | G.H5.22 |
Polar | ICL3 | R | 218 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL3 | R | 218 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL3 | R | 218 | - | G.H5 | R | 380 | G.H5.12 |
Polar | TM3 | A | 122 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 122 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | A | 122 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 122 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | A | 122 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | V | 57 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | V | 57 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 119 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | I | 233 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | I | 233 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Polar | H8 | K | 291 | 8x48 | G.H5 | L | 394 | G.H5.26 |
Polar | TM3 | I | 123 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Ionic | ICL3 | R | 218 | - | G.s2s3 | D | 215 | G.s2s3.01 |
Polar | ICL2 | K | 133 | 34x57 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM6 | V | 226 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | V | 226 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | L | 237 | 6x40 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | K | 221 | 6x24 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM6 | K | 221 | 6x24 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL2 | P | 126 | 34x50 | G.H5 | H | 387 | G.H5.19 |
Polar | ICL2 | K | 130 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | K | 130 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | K | 130 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM6 | S | 230 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM3 | I | 123 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | I | 123 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM2 | T | 55 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | T | 55 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Polar | TM6 | S | 230 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | S | 230 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | S | 230 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Polar | TM6 | L | 222 | 6x25 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM6 | L | 222 | 6x25 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM6 | L | 222 | 6x25 | G.H5 | D | 381 | G.H5.13 |
Polar | ICL2 | K | 130 | 34x54 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | ICL2 | K | 130 | 34x54 | G.hns1 | A | 39 | G.hns1.03 |