GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | P | 134 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Ionic | TM5 | H | 221 | 5x69 | G.H5 | D | 364 | G.H5.13 |
Polar | TM5 | H | 221 | 5x69 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | H | 221 | 5x69 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | H | 221 | 5x69 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | L | 135 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM6 | Q | 243 | 6x26 | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 243 | 6x26 | G.h4s6 | Q | 338 | G.h4s6.12 |
Hydrophobic | TM6 | D | 247 | 6x30 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | D | 247 | 6x30 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | H8 | R | 313 | 8x52 | G.H5 | Q | 377 | G.H5.26 |
Polar | ICL2 | P | 134 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | P | 134 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | P | 134 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Polar | TM3 | R | 127 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 127 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 127 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | I | 131 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Polar | ICL3 | S | 234 | - | G.H4 | K | 324 | G.H4.09 |
Van-der-waals | ICL3 | S | 234 | - | G.H4 | K | 324 | G.H4.09 |
Ionic | TM6 | D | 247 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Polar | TM6 | D | 247 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | D | 247 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Polar | H8 | S | 309 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | S | 309 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM2 | I | 68 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM5 | I | 217 | 5x65 | G.H5 | L | 367 | G.H5.16 |
Polar | TM3 | R | 127 | 3x50 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | L | 135 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | TM6 | P | 246 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | P | 246 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Aromatic | TM5 | F | 232 | 5x80 | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | TM5 | F | 232 | 5x80 | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | TM5 | F | 232 | 5x80 | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | I | 131 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM7 | S | 307 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Polar | TM6 | Q | 243 | 6x26 | G.h4s6 | Q | 337 | G.h4s6.11 |
Hydrophobic | H8 | V | 310 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | L | 135 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Polar | TM3 | A | 130 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | A | 130 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | A | 130 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM5 | C | 218 | 5x66 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | C | 218 | 5x66 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM5 | F | 232 | 5x80 | G.S6 | F | 346 | G.S6.05 |
Van-der-waals | TM5 | F | 232 | 5x80 | G.S6 | F | 346 | G.S6.05 |
Ionic | TM5 | R | 228 | 5x76 | G.H5 | D | 364 | G.H5.13 |
Polar | TM5 | R | 228 | 5x76 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | R | 228 | 5x76 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ICL2 | N | 138 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM6 | V | 253 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | V | 253 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | T | 136 | 34x52 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.H5 | V | 362 | G.H5.11 |
Ionic | TM5 | R | 228 | 5x76 | G.H5 | D | 361 | G.H5.10 |
Polar | TM5 | R | 228 | 5x76 | G.H5 | D | 361 | G.H5.10 |
Hydrophobic | TM6 | Y | 250 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | L | 254 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Polar | TM6 | Y | 250 | 6x33 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | Y | 250 | 6x33 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | Y | 250 | 6x33 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | I | 131 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM3 | A | 130 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | A | 130 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | Y | 250 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | Y | 250 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Polar | TM5 | R | 231 | 5x79 | G.H4 | R | 320 | G.H4.05 |
Hydrophobic | TM6 | Y | 250 | 6x33 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM6 | Y | 250 | 6x33 | G.H5 | K | 372 | G.H5.21 |
Polar | ICL2 | T | 139 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | T | 139 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | T | 139 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL1 | L | 59 | 12x50 | G.H5 | L | 376 | G.H5.25 |
Polar | H8 | V | 310 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Van-der-waals | ICL2 | L | 135 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | TM6 | L | 254 | 6x37 | G.H5 | L | 374 | G.H5.23 |
Polar | ICL2 | N | 138 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | N | 138 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | N | 138 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM2 | H | 62 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM2 | H | 62 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | H | 62 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM5 | R | 228 | 5x76 | G.H5 | R | 360 | G.H5.09 |
Van-der-waals | TM5 | R | 228 | 5x76 | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | H8 | N | 308 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | N | 308 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | H8 | S | 309 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | S | 309 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM5 | H | 221 | 5x69 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | H | 221 | 5x69 | G.H5 | L | 367 | G.H5.16 |