GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM5 | Q | 229 | 5x77 | G.h4s6 | S | 320 | G.h4s6.11 |
Ionic | TM2 | H | 62 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Polar | TM2 | H | 62 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | H | 62 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | H | 62 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Polar | ICL2 | Y | 137 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | I | 217 | 5x65 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM5 | H | 221 | 5x69 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | P | 134 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Polar | TM6 | Q | 243 | 6x26 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | TM6 | V | 253 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | L | 254 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | T | 139 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Polar | ICL3 | Q | 235 | - | G.H4 | K | 311 | G.H4.13 |
Hydrophobic | ICL3 | Q | 235 | - | G.H4 | K | 311 | G.H4.13 |
Van-der-waals | ICL3 | Q | 235 | - | G.H4 | K | 311 | G.H4.13 |
Polar | H8 | S | 309 | 8x48 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | S | 309 | 8x48 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | S | 309 | 8x48 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM5 | C | 218 | 5x66 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM5 | C | 218 | 5x66 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM5 | F | 232 | 5x80 | G.H4 | L | 310 | G.H4.12 |
Van-der-waals | TM5 | F | 232 | 5x80 | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | L | 135 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | TM5 | I | 225 | 5x73 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | TM5 | I | 225 | 5x73 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM5 | R | 228 | 5x76 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | TM5 | R | 228 | 5x76 | G.S6 | Y | 325 | G.S6.02 |
Polar | TM7 | S | 307 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM7 | S | 307 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | S | 307 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Polar | TM6 | R | 249 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | R | 249 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | R | 249 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Ionic | TM5 | R | 228 | 5x76 | G.H5 | D | 346 | G.H5.13 |
Polar | TM5 | R | 228 | 5x76 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM5 | R | 228 | 5x76 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Polar | TM3 | A | 130 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | A | 130 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 130 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | R | 127 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.H5 | V | 344 | G.H5.11 |
Hydrophobic | H8 | N | 308 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | N | 308 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM5 | I | 214 | 5x62 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | Y | 250 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM3 | A | 130 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 130 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | H | 221 | 5x69 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | H | 221 | 5x69 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM4 | P | 143 | 4x39 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM4 | P | 143 | 4x39 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM6 | P | 246 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Polar | TM6 | Y | 250 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | Y | 250 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | Y | 250 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | T | 136 | 34x52 | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | ICL2 | T | 136 | 34x52 | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | TM5 | F | 232 | 5x80 | G.H4 | V | 314 | G.H4.16 |
Polar | TM5 | H | 221 | 5x69 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM5 | H | 221 | 5x69 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM5 | H | 221 | 5x69 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | I | 131 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Ionic | TM5 | R | 231 | 5x79 | G.H4 | E | 307 | G.H4.09 |
Polar | TM5 | R | 231 | 5x79 | G.H4 | E | 307 | G.H4.09 |
Hydrophobic | TM5 | R | 231 | 5x79 | G.H4 | E | 307 | G.H4.09 |
Van-der-waals | TM5 | R | 231 | 5x79 | G.H4 | E | 307 | G.H4.09 |
Polar | TM2 | T | 64 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | T | 64 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | T | 64 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | P | 134 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | L | 135 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | TM6 | V | 253 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Ionic | TM5 | H | 221 | 5x69 | G.H5 | D | 346 | G.H5.13 |
Polar | TM5 | H | 221 | 5x69 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM5 | H | 221 | 5x69 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM5 | H | 221 | 5x69 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM6 | Y | 250 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | Y | 250 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | I | 131 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Polar | TM3 | D | 126 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | I | 225 | 5x73 | G.H5 | Q | 350 | G.H5.17 |
Polar | ICL2 | N | 138 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | N | 138 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | N | 138 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Polar | H8 | S | 309 | 8x48 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | L | 135 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | L | 135 | 34x51 | G.H5 | I | 348 | G.H5.15 |