GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL3 | Q | 250 | - | G.H4 | D | 298 | G.H4.04 |
Hydrophobic | ICL3 | Q | 250 | - | G.H4 | D | 298 | G.H4.04 |
Van-der-waals | ICL3 | Q | 250 | - | G.H4 | D | 298 | G.H4.04 |
Polar | TM3 | R | 140 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 140 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 140 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Aromatic | TM5 | F | 246 | 5x73 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM5 | F | 246 | 5x73 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM5 | F | 246 | 5x73 | G.S6 | Y | 321 | G.S6.02 |
Ionic | TM6 | R | 307 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | R | 307 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | R | 307 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | R | 307 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | V | 311 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | I | 318 | 6x40 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | I | 318 | 6x40 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL3 | R | 296 | - | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | TM6 | R | 307 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | R | 307 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | C-term | I | 401 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | I | 401 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | TM5 | L | 238 | 5x65 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | W | 405 | - | G.H3 | N | 257 | G.H3.15 |
Van-der-waals | C-term | W | 405 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | C-term | W | 405 | - | G.H3 | I | 254 | G.H3.12 |
Van-der-waals | C-term | W | 405 | - | G.H3 | I | 254 | G.H3.12 |
Polar | ICL2 | R | 150 | 34x53 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM5 | R | 241 | 5x68 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | TM5 | R | 241 | 5x68 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM6 | M | 314 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Ionic | ICL3 | R | 296 | - | G.H4 | E | 309 | G.H4.16 |
Polar | ICL3 | R | 296 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | ICL3 | R | 296 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | R | 296 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | H8 | R | 371 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM4 | T | 153 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | T | 153 | 4x38 | G.HN | E | 28 | G.HN.52 |
Ionic | H8 | K | 373 | 8x49 | G.H5 | D | 351 | G.H5.22 |
Polar | H8 | K | 373 | 8x49 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | H8 | K | 373 | 8x49 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | H8 | K | 373 | 8x49 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 147 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM5 | I | 242 | 5x69 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | I | 242 | 5x69 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | H8 | R | 371 | 8x47 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM6 | V | 311 | 6x33 | G.H5 | F | 355 | G.H5.26 |
Polar | C-term | W | 405 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | W | 405 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | W | 405 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | I | 406 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | I | 406 | - | G.H2 | K | 210 | G.H2.05 |
Polar | TM7 | T | 370 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM7 | T | 370 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM7 | T | 370 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Polar | ICL3 | K | 253 | - | G.H4 | S | 302 | G.H4.08 |
Hydrophobic | ICL3 | K | 253 | - | G.H4 | S | 302 | G.H4.08 |
Van-der-waals | ICL3 | K | 253 | - | G.H4 | S | 302 | G.H4.08 |
Polar | TM4 | M | 154 | 4x39 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | M | 154 | 4x39 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | M | 154 | 4x39 | G.HN | E | 28 | G.HN.52 |
Ionic | ICL3 | K | 299 | - | G.h4s6 | D | 316 | G.h4s6.09 |
Polar | ICL3 | K | 299 | - | G.h4s6 | D | 316 | G.h4s6.09 |
Van-der-waals | ICL3 | K | 299 | - | G.h4s6 | D | 316 | G.h4s6.09 |
Hydrophobic | TM5 | R | 241 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM5 | R | 241 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | W | 405 | - | G.H3 | L | 250 | G.H3.08 |
Van-der-waals | C-term | W | 405 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | ICL2 | A | 148 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | A | 148 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM4 | M | 154 | 4x39 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | M | 154 | 4x39 | G.HN | R | 24 | G.HN.48 |
Aromatic | TM5 | F | 246 | 5x73 | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | TM5 | F | 246 | 5x73 | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | TM5 | F | 246 | 5x73 | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | TM5 | L | 238 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM5 | L | 238 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | C-term | I | 401 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | I | 401 | - | G.H3 | W | 259 | G.H3.17 |
Polar | H8 | R | 371 | 8x47 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | H8 | R | 371 | 8x47 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | H8 | R | 371 | 8x47 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM3 | S | 144 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM3 | S | 144 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM5 | R | 245 | 5x72 | G.H5 | Q | 334 | G.H5.05 |
Van-der-waals | TM5 | R | 245 | 5x72 | G.H5 | Q | 334 | G.H5.05 |
Hydrophobic | TM6 | R | 310 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | R | 310 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM6 | R | 307 | 6x29 | G.H5 | K | 346 | G.H5.17 |
Polar | TM6 | V | 311 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | V | 311 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | V | 311 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | R | 150 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | R | 150 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | A | 148 | 34x51 | G.s2s3 | D | 194 | G.s2s3.02 |
Polar | TM3 | I | 143 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | I | 143 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | I | 143 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Polar | ICL2 | N | 149 | 34x52 | G.s2s3 | D | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | N | 149 | 34x52 | G.s2s3 | D | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 149 | 34x52 | G.s2s3 | D | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Polar | C-term | W | 405 | - | G.H2 | R | 209 | G.H2.04 |
Ionic | H8 | K | 376 | 8x52 | G.h3s5 | D | 262 | G.h3s5.02 |
Polar | H8 | K | 376 | 8x52 | G.h3s5 | D | 262 | G.h3s5.02 |
Van-der-waals | H8 | K | 376 | 8x52 | G.h3s5 | D | 262 | G.h3s5.02 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM3 | R | 140 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Ionic | C-term | D | 407 | - | G.H2 | K | 210 | G.H2.05 |
Ionic | ICL3 | R | 300 | - | G.H4 | E | 309 | G.H4.16 |
Polar | ICL3 | R | 300 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | ICL3 | R | 300 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | R | 300 | - | G.H4 | E | 309 | G.H4.16 |
Ionic | ICL3 | K | 253 | - | G.H4 | D | 298 | G.H4.04 |
Polar | ICL3 | K | 253 | - | G.H4 | D | 298 | G.H4.04 |
Van-der-waals | ICL3 | K | 253 | - | G.H4 | D | 298 | G.H4.04 |
Polar | ICL2 | A | 148 | 34x51 | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL3 | R | 296 | - | G.H4 | S | 306 | G.H4.13 |
Hydrophobic | ICL3 | R | 296 | - | G.H4 | S | 306 | G.H4.13 |
Van-der-waals | ICL3 | R | 296 | - | G.H4 | S | 306 | G.H4.13 |
Hydrophobic | TM3 | S | 144 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | S | 144 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM5 | F | 246 | 5x73 | G.H5 | A | 339 | G.H5.10 |
Hydrophobic | TM5 | Y | 231 | 5x58 | G.H5 | L | 354 | G.H5.25 |
Ionic | TM5 | R | 245 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Polar | TM5 | R | 245 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM5 | R | 245 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | TM5 | R | 245 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Ionic | ICL3 | R | 296 | - | G.H4 | D | 310 | G.H4.17 |
Polar | ICL3 | R | 296 | - | G.H4 | D | 310 | G.H4.17 |
Hydrophobic | ICL3 | R | 296 | - | G.H4 | D | 310 | G.H4.17 |
Van-der-waals | ICL3 | R | 296 | - | G.H4 | D | 310 | G.H4.17 |
Hydrophobic | TM5 | I | 234 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Polar | H8 | Q | 372 | 8x48 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | H8 | Q | 372 | 8x48 | G.H5 | K | 350 | G.H5.21 |
Van-der-waals | H8 | Q | 372 | 8x48 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | C-term | I | 406 | - | G.H2 | R | 209 | G.H2.04 |