GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | R | 307 | 6x29 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM6 | R | 307 | 6x29 | G.H5 | R | 372 | G.H5.17 |
Polar | ICL3 | K | 251 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Hydrophobic | ICL3 | K | 251 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Van-der-waals | ICL3 | K | 251 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Hydrophobic | ICL3 | K | 253 | - | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | ICL3 | K | 253 | - | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | TM7 | T | 370 | 7x56 | G.H5 | E | 379 | G.H5.24 |
Polar | ICL3 | R | 300 | - | G.S6 | C | 346 | G.S6.01 |
Hydrophobic | ICL3 | R | 300 | - | G.S6 | C | 346 | G.S6.01 |
Van-der-waals | ICL3 | R | 300 | - | G.S6 | C | 346 | G.S6.01 |
Polar | ICL3 | R | 296 | - | G.H4 | L | 333 | G.H4.16 |
Polar | ICL3 | G | 249 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL3 | G | 249 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | G | 249 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | TM5 | R | 241 | 5x68 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | TM5 | R | 241 | 5x68 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | ICL2 | A | 148 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM6 | M | 314 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | G | 249 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Van-der-waals | ICL3 | G | 249 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Ionic | ICL3 | K | 253 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | ICL3 | K | 253 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL3 | K | 253 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | K | 253 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | ICL2 | R | 150 | 34x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | R | 150 | 34x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | ICL2 | R | 150 | 34x53 | G.H5 | Y | 378 | G.H5.23 |
Polar | H8 | Q | 372 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | Q | 372 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | Q | 372 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Polar | TM2 | S | 75 | 2x37 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL3 | R | 300 | - | G.H4 | L | 333 | G.H4.16 |
Van-der-waals | ICL3 | R | 300 | - | G.H4 | L | 333 | G.H4.16 |
Hydrophobic | TM6 | V | 311 | 6x33 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | C-term | W | 405 | - | G.H3 | S | 262 | G.H3.11 |
Van-der-waals | C-term | W | 405 | - | G.H3 | S | 262 | G.H3.11 |
Hydrophobic | TM3 | S | 144 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL3 | R | 300 | - | G.S6 | P | 348 | G.S6.03 |
Van-der-waals | ICL3 | R | 300 | - | G.S6 | P | 348 | G.S6.03 |
Hydrophobic | C-term | I | 401 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | I | 401 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | ICL2 | A | 148 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | A | 148 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | H8 | R | 371 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | R | 371 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | R | 307 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | R | 307 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM3 | I | 143 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | I | 143 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Polar | TM6 | R | 310 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | R | 310 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | R | 310 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Polar | TM6 | V | 311 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | V | 311 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | V | 311 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | T | 248 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | ICL3 | T | 248 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL3 | K | 253 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Van-der-waals | ICL3 | K | 253 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Hydrophobic | C-term | W | 405 | - | G.H3 | N | 265 | G.H3.14 |
Polar | TM2 | S | 75 | 2x37 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | S | 75 | 2x37 | G.H5 | Y | 378 | G.H5.23 |
Polar | ICL3 | R | 296 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | ICL3 | R | 296 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Van-der-waals | ICL3 | R | 296 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Polar | ICL3 | Q | 250 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Hydrophobic | ICL3 | Q | 250 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Van-der-waals | ICL3 | Q | 250 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Hydrophobic | TM3 | I | 143 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | I | 143 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Polar | ICL2 | A | 148 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Polar | ICL3 | Q | 250 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | TM5 | L | 238 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | L | 238 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Polar | TM5 | R | 241 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM5 | R | 241 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | R | 241 | 5x68 | G.H5 | Q | 371 | G.H5.16 |
Polar | ICL3 | K | 253 | - | G.hgh4 | P | 308 | G.hgh4.11 |
Hydrophobic | ICL3 | K | 253 | - | G.hgh4 | P | 308 | G.hgh4.11 |
Van-der-waals | ICL3 | K | 253 | - | G.hgh4 | P | 308 | G.hgh4.11 |
Ionic | TM5 | R | 245 | 5x72 | G.H5 | E | 357 | G.H5.02 |
Polar | TM5 | R | 245 | 5x72 | G.H5 | E | 357 | G.H5.02 |
Polar | H8 | F | 374 | 8x50 | G.H5 | E | 379 | G.H5.24 |
Polar | TM6 | R | 307 | 6x29 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM6 | R | 307 | 6x29 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM6 | R | 307 | 6x29 | G.h4s6 | Y | 345 | G.h4s6.20 |
Polar | C-term | N | 403 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM5 | L | 238 | 5x65 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | R | 140 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | K | 253 | - | G.H4 | F | 326 | G.H4.08 |
Van-der-waals | ICL3 | K | 253 | - | G.H4 | F | 326 | G.H4.08 |
Hydrophobic | H8 | R | 371 | 8x47 | G.H5 | Y | 378 | G.H5.23 |
Polar | ICL3 | K | 252 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Hydrophobic | ICL3 | K | 252 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Van-der-waals | ICL3 | K | 252 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Hydrophobic | ICL3 | K | 253 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Van-der-waals | ICL3 | K | 253 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Hydrophobic | C-term | W | 405 | - | G.H3 | N | 266 | G.H3.15 |
Van-der-waals | C-term | W | 405 | - | G.H3 | N | 266 | G.H3.15 |
Hydrophobic | TM5 | S | 247 | 5x74 | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | TM5 | S | 247 | 5x74 | G.hgh4 | T | 312 | G.hgh4.15 |
Polar | ICL3 | A | 254 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL3 | R | 296 | - | G.H4 | R | 334 | G.H4.17 |
Polar | ICL2 | R | 150 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Aromatic | ICL2 | R | 150 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | R | 150 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | R | 150 | 34x53 | G.H5 | H | 374 | G.H5.19 |
Ionic | TM6 | R | 304 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Polar | TM6 | R | 304 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM6 | R | 304 | 6x26 | G.H5 | D | 368 | G.H5.13 |
Polar | ICL2 | P | 147 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 147 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | TM6 | E | 303 | 6x25 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | ICL3 | A | 297 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | A | 297 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | H8 | K | 373 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | K | 373 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | K | 373 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Aromatic | ICL3 | R | 300 | - | G.S6 | Y | 347 | G.S6.02 |
Polar | TM3 | S | 144 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | S | 144 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | S | 144 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM2 | S | 77 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | S | 77 | 2x39 | G.H5 | Y | 378 | G.H5.23 |