Ggust - GPR22 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar C-term W 405 - G.H3 S 252 G.H3.11
Hydrophobic C-term W 405 - G.H3 S 252 G.H3.11
Van-der-waals C-term W 405 - G.H3 S 252 G.H3.11
Hydrophobic ICL2 P 147 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 147 34x50 G.H5 I 343 G.H5.15
Polar C-term W 405 - G.H2 R 208 G.H2.04
Hydrophobic C-term W 405 - G.H2 R 208 G.H2.04
Van-der-waals C-term W 405 - G.H2 R 208 G.H2.04
Hydrophobic TM3 I 143 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 143 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM4 M 154 4x39 G.HN Q 24 G.HN.48
Van-der-waals TM4 M 154 4x39 G.HN Q 24 G.HN.48
Hydrophobic TM6 V 311 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 A 148 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 V 311 6x33 G.H5 L 348 G.H5.20
Polar ICL2 R 150 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 150 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 A 148 34x51 G.s2s3 K 192 G.s2s3.01
Polar TM6 R 310 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 310 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 310 6x32 G.H5 F 354 G.H5.26
Aromatic C-term W 405 - G.H3 H 256 G.H3.15
Hydrophobic C-term W 405 - G.H3 H 256 G.H3.15
Van-der-waals C-term W 405 - G.H3 H 256 G.H3.15
Hydrophobic ICL3 K 253 - G.H4 N 301 G.H4.08
Polar ICL3 Q 250 - G.H4 D 298 G.H4.05
Hydrophobic C-term I 401 - G.H3 K 257 G.H3.16
Van-der-waals C-term I 401 - G.H3 K 257 G.H3.16
Ionic H8 K 373 8x49 G.H5 D 350 G.H5.22
Polar H8 K 373 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 K 373 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 K 373 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM6 R 307 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 307 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM4 T 153 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 T 153 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 M 314 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 S 144 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 S 144 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 S 144 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 S 144 3x54 G.H5 I 344 G.H5.16
Polar H8 R 371 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 R 371 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 R 371 8x47 G.H5 D 350 G.H5.22
Hydrophobic TM5 L 238 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 238 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 R 241 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 241 5x68 G.H5 I 344 G.H5.16
Polar TM6 R 307 6x29 G.h4s6 E 315 G.h4s6.09
Van-der-waals TM6 R 307 6x29 G.h4s6 E 315 G.h4s6.09
Polar TM7 T 370 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 T 370 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 T 370 7x56 G.H5 G 352 G.H5.24
Hydrophobic H8 R 371 8x47 G.H5 G 352 G.H5.24
Polar C-term N 403 - G.H3 H 256 G.H3.15
Hydrophobic TM3 R 140 3x50 G.H5 L 353 G.H5.25
Ionic ICL3 K 253 - G.H4 D 298 G.H4.05
Polar ICL3 K 253 - G.H4 D 298 G.H4.05
Van-der-waals ICL3 K 253 - G.H4 D 298 G.H4.05
Ionic TM6 R 307 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 307 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 307 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 Y 231 5x58 G.H5 L 353 G.H5.25
Ionic C-term D 407 - G.H2 K 209 G.H2.05
Ionic ICL3 K 299 - G.h4s6 E 315 G.h4s6.09
Polar ICL3 K 299 - G.h4s6 E 315 G.h4s6.09
Van-der-waals ICL3 K 299 - G.h4s6 E 315 G.h4s6.09
Hydrophobic ICL2 P 147 34x50 G.H5 I 344 G.H5.16
Polar TM5 R 245 5x72 G.H5 D 337 G.H5.09
Ionic TM5 R 245 5x72 G.h4s6 E 318 G.h4s6.12
Polar TM5 R 245 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 245 5x72 G.h4s6 E 318 G.h4s6.12
Ionic TM5 R 245 5x72 G.H5 D 341 G.H5.13
Polar TM5 R 245 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 245 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 245 5x72 G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 300 - G.H4 L 308 G.H4.16
Van-der-waals ICL3 R 300 - G.H4 L 308 G.H4.16
Hydrophobic H8 R 371 8x47 G.H5 C 351 G.H5.23
Polar H8 Q 372 8x48 G.H5 K 349 G.H5.21
Hydrophobic H8 Q 372 8x48 G.H5 K 349 G.H5.21
Van-der-waals H8 Q 372 8x48 G.H5 K 349 G.H5.21
Polar TM5 I 242 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM5 I 242 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 I 242 5x69 G.H5 D 341 G.H5.13
Polar TM6 V 311 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 311 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 311 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 241 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 241 5x68 G.H5 T 340 G.H5.12
Ionic ICL3 R 296 - G.H4 D 309 G.H4.17
Polar ICL3 R 296 - G.H4 D 309 G.H4.17
Hydrophobic ICL3 R 296 - G.H4 D 309 G.H4.17
Van-der-waals ICL3 R 296 - G.H4 D 309 G.H4.17
Polar TM3 I 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 143 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 143 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 I 234 5x61 G.H5 L 348 G.H5.20
Hydrophobic TM6 E 303 6x25 G.h4s6 E 315 G.h4s6.09
Van-der-waals TM6 E 303 6x25 G.h4s6 E 315 G.h4s6.09
Hydrophobic C-term P 408 - G.H2 R 205 G.H2.01
Hydrophobic ICL2 P 147 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM6 R 307 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 307 6x29 G.H5 K 345 G.H5.17
Hydrophobic ICL2 A 148 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 A 148 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 R 241 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 241 5x68 G.H5 D 341 G.H5.13
Polar TM6 R 307 6x29 G.h4s6 D 316 G.h4s6.10
Hydrophobic C-term W 405 - G.H3 I 253 G.H3.12
Van-der-waals C-term W 405 - G.H3 I 253 G.H3.12
Hydrophobic TM5 R 245 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 R 245 5x72 G.S6 Y 320 G.S6.02
Hydrophobic C-term I 406 - G.H2 K 209 G.H2.05
Van-der-waals C-term I 406 - G.H2 K 209 G.H2.05
Polar TM4 M 154 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 M 154 4x39 G.HN E 28 G.HN.52
Hydrophobic TM6 I 318 6x40 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 318 6x40 G.H5 L 353 G.H5.25
Polar ICL2 N 149 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 N 149 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 149 34x52 G.s2s3 D 193 G.s2s3.02
Polar TM3 R 140 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 C 351 G.H5.23
Polar C-term A 399 - G.H3 K 257 G.H3.16
Hydrophobic C-term W 405 - G.H3 L 249 G.H3.08
Van-der-waals C-term W 405 - G.H3 L 249 G.H3.08
Hydrophobic C-term I 401 - G.H3 H 256 G.H3.15
Polar C-term S 404 - G.H3 S 252 G.H3.11
Van-der-waals C-term S 404 - G.H3 S 252 G.H3.11
Polar ICL2 N 149 34x52 G.hns1 R 32 G.hns1.03