Gi2 - GPR25 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM6 I 245 6x36 G.H5 F 355 G.H5.26
Hydrophobic C-term F 347 - G.H2 W 212 G.H2.07
Polar TM3 R 137 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 137 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 145 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 145 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL3 V 235 - G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 144 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 L 144 34x50 G.H5 I 345 G.H5.16
Polar ICL2 L 145 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 145 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 145 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 144 34x50 G.S3 L 195 G.S3.01
Polar C-term C 349 - G.H2 K 210 G.H2.05
Hydrophobic C-term C 349 - G.H2 K 210 G.H2.05
Van-der-waals C-term C 349 - G.H2 K 210 G.H2.05
Hydrophobic C-term V 346 - G.H3 S 253 G.H3.11
Hydrophobic TM3 V 141 3x54 G.H5 C 352 G.H5.23
Polar TM3 A 140 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 140 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 N 348 G.H5.19
Polar ICL3 H 234 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 H 234 - G.H5 D 342 G.H5.13
Hydrophobic TM2 V 74 2x39 G.H5 G 353 G.H5.24
Hydrophobic ICL3 H 234 - G.S6 Y 321 G.S6.02
Hydrophobic TM6 I 246 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM2 R 72 2x37 G.H5 G 353 G.H5.24
Van-der-waals TM2 R 72 2x37 G.H5 G 353 G.H5.24
Hydrophobic C-term F 347 - G.H3 I 254 G.H3.12
Polar TM3 R 137 3x50 G.H5 G 353 G.H5.24
Hydrophobic TM2 V 74 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 V 74 2x39 G.H5 C 352 G.H5.23
Van-der-waals C-term F 347 - G.H2 K 210 G.H2.05
Aromatic ICL3 H 234 - G.S6 H 323 G.S6.04
Hydrophobic ICL3 H 234 - G.S6 H 323 G.S6.04
Polar TM6 N 241 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 N 241 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 N 241 6x32 G.H5 F 355 G.H5.26
Polar ICL2 R 148 34x54 G.S1 E 33 G.S1.01
Polar TM2 R 72 2x37 G.H5 K 350 G.H5.21
Van-der-waals TM2 R 72 2x37 G.H5 K 350 G.H5.21
Hydrophobic ICL2 L 144 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM6 I 245 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 245 6x36 G.H5 L 354 G.H5.25
Ionic C-term D 342 - G.H3 K 258 G.H3.16
Polar C-term D 342 - G.H3 K 258 G.H3.16
Hydrophobic TM5 L 229 5x65 G.H5 I 345 G.H5.16
Van-der-waals TM5 L 229 5x65 G.H5 I 345 G.H5.16
Hydrophobic ICL3 V 235 - G.H5 D 342 G.H5.13
Hydrophobic TM3 V 141 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 141 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM6 S 242 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 S 242 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 144 34x50 G.H5 T 341 G.H5.12
Hydrophobic TM3 A 140 3x53 G.H5 C 352 G.H5.23
Hydrophobic C-term F 347 - G.H2 R 209 G.H2.04
Van-der-waals C-term F 347 - G.H2 R 209 G.H2.04
Hydrophobic ICL3 P 232 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 P 232 - G.H5 D 342 G.H5.13
Hydrophobic C-term V 346 - G.H2 R 209 G.H2.04
Van-der-waals C-term V 346 - G.H2 R 209 G.H2.04
Hydrophobic ICL3 V 235 - G.H5 L 349 G.H5.20
Polar ICL2 E 146 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 E 146 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 238 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 A 238 6x29 G.H5 F 355 G.H5.26
Hydrophobic C-term F 347 - G.h2s4 F 216 G.h2s4.01
Hydrophobic TM6 A 238 6x29 G.H5 K 346 G.H5.17
Polar H8 R 312 8x48 G.H5 F 355 G.H5.26
Aromatic H8 R 312 8x48 G.H5 F 355 G.H5.26
Hydrophobic H8 R 312 8x48 G.H5 F 355 G.H5.26
Van-der-waals H8 R 312 8x48 G.H5 F 355 G.H5.26
Hydrophobic H8 D 311 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 D 311 8x47 G.H5 G 353 G.H5.24
Polar ICL2 R 148 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 148 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 148 34x54 G.hns1 A 31 G.hns1.02
Polar TM2 R 72 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM2 R 72 2x37 G.H5 D 351 G.H5.22
Van-der-waals TM2 R 72 2x37 G.H5 D 351 G.H5.22
Polar TM6 S 242 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 S 242 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 242 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 149 34x55 G.HN E 28 G.HN.52
Hydrophobic TM6 A 238 6x29 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 145 34x51 G.H5 I 344 G.H5.15
Hydrophobic ICL2 E 146 34x52 G.s2s3 D 194 G.s2s3.02
Hydrophobic TM2 V 74 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 V 74 2x39 G.H5 D 351 G.H5.22
Hydrophobic C-term V 346 - G.H3 L 250 G.H3.08
Hydrophobic TM5 L 229 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL3 P 232 - G.H5 I 345 G.H5.16
Ionic ICL2 R 151 34x57 G.H5 D 351 G.H5.22
Polar ICL2 R 151 34x57 G.H5 D 351 G.H5.22
Van-der-waals ICL2 R 151 34x57 G.H5 D 351 G.H5.22
Hydrophobic ICL2 P 149 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 149 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 145 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 145 34x51 G.S1 V 34 G.S1.02