G11 - GPR33 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 86.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 Q 138 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 Q 138 34x55 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 V 134 34x51 G.S1 L 40 G.S1.02
Polar H8 E 304 8x48 G.H5 N 357 G.H5.24
Hydrophobic H8 E 304 8x48 G.H5 N 357 G.H5.24
Van-der-waals H8 E 304 8x48 G.H5 N 357 G.H5.24
Hydrophobic ICL2 V 134 34x51 G.H5 I 348 G.H5.15
Ionic TM5 R 235 5x68 G.H5 D 346 G.H5.13
Polar TM5 R 235 5x68 G.H5 D 346 G.H5.13
Hydrophobic TM5 R 235 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 R 235 5x68 G.H5 D 346 G.H5.13
Hydrophobic ICL3 L 237 - G.H5 L 353 G.H5.20
Hydrophobic ICL2 V 134 34x51 G.S3 I 199 G.S3.01
Van-der-waals ICL2 V 134 34x51 G.S3 I 199 G.S3.01
Hydrophobic ICL2 P 133 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM6 V 246 6x36 G.H5 L 358 G.H5.25
Polar ICL2 S 136 34x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 Q 137 34x54 G.S1 L 40 G.S1.02
Hydrophobic H8 G 303 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 G 303 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM5 V 232 5x65 G.H5 L 353 G.H5.20
Ionic ICL3 K 239 - G.h4s6 D 321 G.h4s6.12
Polar ICL3 K 239 - G.h4s6 D 321 G.h4s6.12
Van-der-waals ICL3 K 239 - G.h4s6 D 321 G.h4s6.12
Hydrophobic ICL2 P 133 34x50 G.H5 L 349 G.H5.16
Polar TM6 P 243 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 P 243 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 P 243 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM7 V 302 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 V 302 7x56 G.H5 N 357 G.H5.24
Hydrophobic ICL2 Q 137 34x54 G.H5 I 348 G.H5.15
Van-der-waals ICL2 Q 137 34x54 G.H5 I 348 G.H5.15
Hydrophobic TM6 P 243 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM3 T 130 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 T 130 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL3 L 237 - G.H5 D 346 G.H5.13
Hydrophobic ICL3 L 237 - G.H5 Q 350 G.H5.17
Van-der-waals ICL3 L 237 - G.H5 Q 350 G.H5.17
Polar TM6 K 242 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM6 K 242 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 242 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM3 L 129 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 L 129 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM6 M 247 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM5 R 235 5x68 G.H5 L 349 G.H5.16
Polar ICL2 Q 138 34x55 G.s2s3 N 198 G.s2s3.02
Van-der-waals ICL2 Q 138 34x55 G.s2s3 N 198 G.s2s3.02
Hydrophobic ICL2 V 134 34x51 G.H5 K 345 G.H5.12
Polar ICL3 K 239 - G.h4s6 S 320 G.h4s6.11
Van-der-waals ICL3 K 239 - G.h4s6 S 320 G.h4s6.11
Polar TM3 L 129 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 L 129 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 L 129 3x53 G.H5 N 352 G.H5.19
Hydrophobic ICL2 P 133 34x50 G.H5 K 345 G.H5.12
Van-der-waals ICL2 P 133 34x50 G.H5 K 345 G.H5.12
Polar ICL2 R 140 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 R 140 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 R 140 34x57 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 Y 356 G.H5.23
Polar TM2 N 63 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 N 63 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 N 63 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM5 V 228 5x61 G.H5 L 358 G.H5.25
Hydrophobic ICL3 L 237 - G.H5 L 349 G.H5.16
Van-der-waals ICL3 L 237 - G.H5 L 349 G.H5.16
Ionic ICL2 R 140 34x57 G.H5 E 355 G.H5.22
Polar ICL2 R 140 34x57 G.H5 E 355 G.H5.22
Polar TM3 D 125 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 125 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 125 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM4 T 141 4x38 G.hns1 R 37 G.hns1.02