G12 - GPR33 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 17.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 Q 137 34x54 G.H5 E 373 G.H5.18
Hydrophobic H8 N 305 8x49 G.H5 Q 381 G.H5.26
Polar TM2 N 63 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 N 63 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM3 T 130 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 T 130 3x54 G.H5 I 378 G.H5.23
Polar ICL2 H 139 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 139 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 139 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 V 134 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL3 F 238 - G.H5 M 379 G.H5.24
Van-der-waals ICL3 F 238 - G.H5 M 379 G.H5.24
Hydrophobic TM3 L 129 3x53 G.H5 I 378 G.H5.23
Polar TM5 R 235 5x68 G.H5 H 364 G.H5.09
Hydrophobic TM5 R 235 5x68 G.H5 H 364 G.H5.09
Van-der-waals TM5 R 235 5x68 G.H5 H 364 G.H5.09
Hydrophobic ICL3 L 237 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 L 237 - G.H5 Q 372 G.H5.17
Hydrophobic ICL2 P 133 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL3 L 237 - G.H5 D 368 G.H5.13
Hydrophobic ICL2 Q 138 34x55 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Q 138 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 T 130 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 T 130 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM3 T 130 3x54 G.H5 L 375 G.H5.20
Polar TM3 R 126 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL3 L 237 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 L 237 - G.H5 L 371 G.H5.16
Hydrophobic TM5 R 235 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 Q 137 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 Q 137 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL3 L 237 - G.H5 L 375 G.H5.20
Hydrophobic TM2 N 63 2x39 G.H5 L 380 G.H5.25
Hydrophobic TM5 V 232 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 V 232 5x65 G.H5 L 375 G.H5.20
Polar H8 E 304 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 E 304 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 F 238 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 F 238 - G.H5 L 375 G.H5.20
Polar TM3 L 129 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 129 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 129 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 133 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 133 34x50 G.H5 I 370 G.H5.15
Ionic ICL2 R 140 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 140 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 140 34x57 G.H5 D 377 G.H5.22
Hydrophobic H8 G 303 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 G 303 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM6 P 243 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 P 243 6x33 G.H5 M 379 G.H5.24
Polar TM3 L 131 3x55 G.H5 K 367 G.H5.12
Polar H8 N 305 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 N 305 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 N 305 8x49 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 299 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 133 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 133 34x50 G.H5 K 367 G.H5.12
Polar H8 E 304 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 E 304 8x48 G.H5 L 380 G.H5.25
Polar ICL2 P 133 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 133 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 133 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM6 M 247 6x37 G.H5 I 378 G.H5.23
Polar ICL2 Q 138 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Q 138 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Q 138 34x55 G.hns1 R 56 G.hns1.03
Ionic TM5 R 235 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 235 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 235 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 235 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM2 F 67 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 F 67 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL2 V 134 34x51 G.S3 I 221 G.S3.01