G12 - GPR34 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL1 R 84 - G.HN R 51 G.HN.51
Hydrophobic ICL2 I 160 - G.H5 L 375 G.H5.20
Van-der-waals ICL2 I 160 - G.H5 L 375 G.H5.20
Hydrophobic TM6 N 267 6x37 G.H5 L 380 G.H5.25
Polar TM6 Y 261 6x31 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Y 261 6x31 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Y 261 6x31 G.H5 Q 372 G.H5.17
Hydrophobic ICL1 K 85 - G.HN R 51 G.HN.51
Van-der-waals ICL1 K 85 - G.HN R 51 G.HN.51
Polar TM6 K 260 6x30 G.h3s5 N 288 G.h3s5.02
Hydrophobic TM6 K 260 6x30 G.h3s5 N 288 G.h3s5.02
Van-der-waals TM6 K 260 6x30 G.h3s5 N 288 G.h3s5.02
Polar TM1 H 83 1x61 G.HN R 51 G.HN.51
Hydrophobic TM1 H 83 1x61 G.HN R 51 G.HN.51
Van-der-waals TM1 H 83 1x61 G.HN R 51 G.HN.51
Aromatic TM6 Y 261 6x31 G.H5 K 376 G.H5.21
Hydrophobic TM6 Y 261 6x31 G.H5 K 376 G.H5.21
Van-der-waals TM6 Y 261 6x31 G.H5 K 376 G.H5.21
Polar ICL1 K 85 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 K 85 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 P 256 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 P 256 - G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 S 258 6x28 G.H5 K 376 G.H5.21
Hydrophobic TM5 I 248 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 248 5x68 G.H5 Q 372 G.H5.17
Polar ICL1 R 86 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 I 160 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 N 257 - G.S5 S 290 G.S5.01
Hydrophobic TM6 T 264 6x34 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 264 6x34 G.H5 L 380 G.H5.25
Polar H8 S 332 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 332 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 F 255 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 P 256 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 P 256 - G.S6 F 347 G.S6.02
Polar TM7 M 330 7x56 G.H5 Q 381 G.H5.26
Hydrophobic TM2 N 87 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 N 87 2x37 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 I 89 2x39 G.H5 Q 381 G.H5.26
Van-der-waals TM2 I 89 2x39 G.H5 Q 381 G.H5.26
Polar ICL3 R 252 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 R 252 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 R 252 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 F 255 - G.H5 T 369 G.H5.14
Van-der-waals ICL3 F 255 - G.H5 T 369 G.H5.14
Polar ICL3 R 252 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 252 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 252 - G.H5 D 368 G.H5.13
Hydrophobic TM3 I 156 3x54 G.H5 M 379 G.H5.24
Van-der-waals TM3 I 156 3x54 G.H5 M 379 G.H5.24
Polar H8 S 332 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 S 332 8x48 G.H5 L 380 G.H5.25
Polar TM2 Q 90 2x40 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 Q 90 2x40 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 I 248 5x68 G.H5 K 376 G.H5.21
Van-der-waals TM5 I 248 5x68 G.H5 K 376 G.H5.21
Aromatic ICL3 F 255 - G.S6 F 347 G.S6.02
Hydrophobic ICL3 F 255 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 F 255 - G.S6 F 347 G.S6.02
Polar ICL3 R 252 - G.H5 T 369 G.H5.14
Hydrophobic ICL3 R 252 - G.H5 T 369 G.H5.14
Van-der-waals ICL3 R 252 - G.H5 T 369 G.H5.14
Polar ICL3 N 257 - G.h3s5 V 289 G.h3s5.03
Van-der-waals ICL3 N 257 - G.h3s5 V 289 G.h3s5.03
Polar ICL1 K 85 - G.HN A 48 G.HN.48
Hydrophobic ICL1 K 85 - G.HN A 48 G.HN.48
Van-der-waals ICL1 K 85 - G.HN A 48 G.HN.48
Ionic TM6 K 260 6x30 G.H5 D 377 G.H5.22
Polar TM6 K 260 6x30 G.H5 D 377 G.H5.22
Hydrophobic TM6 K 260 6x30 G.H5 D 377 G.H5.22
Van-der-waals TM6 K 260 6x30 G.H5 D 377 G.H5.22
Hydrophobic H8 S 331 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 331 8x47 G.H5 L 380 G.H5.25
Polar ICL2 T 168 - G.HN R 52 G.HN.52
Van-der-waals ICL2 T 168 - G.HN R 52 G.HN.52
Polar ICL3 N 257 - G.H5 E 373 G.H5.18
Hydrophobic ICL3 N 257 - G.H5 E 373 G.H5.18
Van-der-waals ICL3 N 257 - G.H5 E 373 G.H5.18
Hydrophobic ICL3 P 256 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 P 256 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 T 264 6x34 G.H5 M 379 G.H5.24
Hydrophobic TM7 M 330 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 M 330 7x56 G.H5 L 380 G.H5.25
Van-der-waals ICL1 K 85 - G.HN R 52 G.HN.52
Polar TM6 Y 261 6x31 G.H5 E 373 G.H5.18
Hydrophobic TM6 Y 261 6x31 G.H5 E 373 G.H5.18
Van-der-waals TM6 Y 261 6x31 G.H5 E 373 G.H5.18
Hydrophobic H8 S 331 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 331 8x47 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 K 254 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 K 254 - G.h4s6 P 345 G.h4s6.20
Polar TM3 R 152 3x50 G.H5 M 379 G.H5.24
Polar ICL3 N 257 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL3 N 257 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 N 257 - G.h4s6 K 344 G.h4s6.19
Hydrophobic TM5 L 245 5x65 G.H5 M 379 G.H5.24
Hydrophobic TM6 K 260 6x30 G.H5 K 376 G.H5.21
Hydrophobic ICL2 I 160 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 I 160 - G.S3 I 221 G.S3.01
Polar TM6 Y 261 6x31 G.H5 T 369 G.H5.14
Ionic TM6 K 260 6x30 G.H5 E 373 G.H5.18
Polar TM6 K 260 6x30 G.H5 E 373 G.H5.18
Van-der-waals TM6 K 260 6x30 G.H5 E 373 G.H5.18
Polar ICL1 K 85 - G.HN L 47 G.HN.47
Hydrophobic ICL1 K 85 - G.HN L 47 G.HN.47
Van-der-waals ICL1 K 85 - G.HN L 47 G.HN.47
Polar H8 N 333 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 333 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 333 8x49 G.H5 Q 381 G.H5.26
Polar ICL2 R 163 - G.hns1 R 56 G.hns1.03
Polar TM2 N 87 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM2 N 87 2x37 G.H5 Q 381 G.H5.26
Van-der-waals TM2 N 87 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM3 K 155 3x53 G.H5 M 379 G.H5.24
Hydrophobic ICL2 R 163 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL3 K 254 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 K 254 - G.S6 F 347 G.S6.02