GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | S | 159 | 3x57 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL3 | N | 257 | - | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | ICL3 | N | 257 | - | G.h4s6 | Y | 345 | G.h4s6.20 |
Ionic | ICL1 | R | 84 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Polar | TM6 | K | 260 | 6x30 | G.h4s6 | K | 343 | G.h4s6.12 |
Hydrophobic | TM6 | K | 260 | 6x30 | G.h4s6 | K | 343 | G.h4s6.12 |
Van-der-waals | TM6 | K | 260 | 6x30 | G.h4s6 | K | 343 | G.h4s6.12 |
Polar | TM5 | I | 248 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | I | 248 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | I | 248 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Polar | ICL2 | Q | 161 | - | G.s2s3 | K | 203 | G.s2s3.02 |
Hydrophobic | ICL2 | Q | 161 | - | G.s2s3 | K | 203 | G.s2s3.02 |
Van-der-waals | ICL2 | Q | 161 | - | G.s2s3 | K | 203 | G.s2s3.02 |
Polar | ICL3 | R | 252 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL3 | R | 252 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | R | 252 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL2 | T | 167 | - | G.HN | L | 37 | G.HN.52 |
Van-der-waals | ICL2 | T | 167 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | TM3 | K | 155 | 3x53 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | K | 155 | 3x53 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | R | 163 | - | G.S3 | N | 205 | G.S3.02 |
Hydrophobic | ICL2 | R | 163 | - | G.S3 | N | 205 | G.S3.02 |
Van-der-waals | ICL2 | R | 163 | - | G.S3 | N | 205 | G.S3.02 |
Hydrophobic | ICL3 | R | 252 | - | G.H5 | I | 369 | G.H5.14 |
Van-der-waals | ICL3 | R | 252 | - | G.H5 | I | 369 | G.H5.14 |
Polar | ICL1 | K | 85 | - | G.hns1 | Y | 39 | G.hns1.01 |
Aromatic | ICL1 | K | 85 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | ICL1 | K | 85 | - | G.hns1 | Y | 39 | G.hns1.01 |
Van-der-waals | ICL1 | K | 85 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | ICL3 | F | 255 | - | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | TM6 | T | 264 | 6x34 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | T | 264 | 6x34 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL1 | K | 85 | - | G.HN | R | 36 | G.HN.51 |
Polar | TM6 | K | 260 | 6x30 | G.h4s6 | G | 342 | G.h4s6.11 |
Hydrophobic | TM6 | K | 260 | 6x30 | G.h4s6 | G | 342 | G.h4s6.11 |
Van-der-waals | TM6 | K | 260 | 6x30 | G.h4s6 | G | 342 | G.h4s6.11 |
Polar | TM6 | K | 260 | 6x30 | G.h4s6 | H | 344 | G.h4s6.13 |
Van-der-waals | TM6 | K | 260 | 6x30 | G.h4s6 | H | 344 | G.h4s6.13 |
Hydrophobic | TM2 | I | 89 | 2x39 | G.H5 | E | 379 | G.H5.24 |
Polar | TM2 | Q | 90 | 2x40 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM2 | Q | 90 | 2x40 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM2 | Q | 90 | 2x40 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | K | 155 | 3x53 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | K | 155 | 3x53 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL3 | F | 255 | - | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | ICL3 | F | 255 | - | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | TM4 | K | 169 | 4x40 | G.HN | K | 34 | G.HN.49 |
Van-der-waals | ICL3 | K | 254 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Polar | ICL3 | P | 256 | - | G.h4s6 | Y | 345 | G.h4s6.20 |
Polar | ICL2 | I | 160 | - | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | ICL2 | I | 160 | - | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | I | 160 | - | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | TM2 | I | 89 | 2x39 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | I | 89 | 2x39 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | Q | 161 | - | G.s2s3 | D | 202 | G.s2s3.01 |
Hydrophobic | ICL2 | Q | 161 | - | G.s2s3 | D | 202 | G.s2s3.01 |
Van-der-waals | ICL2 | Q | 161 | - | G.s2s3 | D | 202 | G.s2s3.01 |
Polar | TM6 | Y | 261 | 6x31 | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | TM6 | Y | 261 | 6x31 | G.S6 | Y | 347 | G.S6.02 |
Ionic | ICL3 | R | 252 | - | G.H5 | D | 365 | G.H5.10 |
Polar | ICL3 | R | 252 | - | G.H5 | D | 365 | G.H5.10 |
Hydrophobic | ICL3 | R | 252 | - | G.H5 | D | 365 | G.H5.10 |
Van-der-waals | ICL3 | R | 252 | - | G.H5 | D | 365 | G.H5.10 |
Polar | H8 | S | 331 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | S | 331 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | S | 331 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | S | 332 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Ionic | ICL1 | K | 85 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Polar | ICL1 | K | 85 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Polar | ICL2 | R | 163 | - | G.S2 | Q | 200 | G.S2.07 |
Hydrophobic | ICL2 | R | 163 | - | G.S2 | Q | 200 | G.S2.07 |
Van-der-waals | ICL2 | R | 163 | - | G.S2 | Q | 200 | G.S2.07 |
Hydrophobic | TM5 | L | 245 | 5x65 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | K | 260 | 6x30 | G.H5 | K | 376 | G.H5.21 |
Polar | TM4 | K | 169 | 4x40 | G.HN | Q | 33 | G.HN.48 |
Hydrophobic | TM4 | K | 169 | 4x40 | G.HN | Q | 33 | G.HN.48 |
Van-der-waals | TM4 | K | 169 | 4x40 | G.HN | Q | 33 | G.HN.48 |
Polar | ICL3 | N | 257 | - | G.S6 | C | 346 | G.S6.01 |
Van-der-waals | ICL3 | N | 257 | - | G.S6 | C | 346 | G.S6.01 |
Hydrophobic | ICL3 | F | 255 | - | G.S6 | P | 348 | G.S6.03 |
Polar | TM2 | N | 87 | 2x37 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM2 | N | 87 | 2x37 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | N | 87 | 2x37 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM2 | N | 87 | 2x37 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM2 | N | 87 | 2x37 | G.H5 | E | 379 | G.H5.24 |
Polar | ICL3 | K | 254 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | K | 254 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | TM6 | Y | 261 | 6x31 | G.H5 | R | 372 | G.H5.17 |
Aromatic | TM6 | Y | 261 | 6x31 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM6 | Y | 261 | 6x31 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM6 | Y | 261 | 6x31 | G.H5 | R | 372 | G.H5.17 |
Polar | TM3 | R | 152 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | R | 152 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | I | 160 | - | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | I | 160 | - | G.S1 | H | 43 | G.S1.02 |
Polar | ICL3 | N | 257 | - | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | ICL3 | N | 257 | - | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | ICL3 | N | 257 | - | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM3 | I | 156 | 3x54 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | I | 160 | - | G.s2s3 | K | 203 | G.s2s3.02 |
Polar | TM4 | K | 169 | 4x40 | G.HN | K | 30 | G.HN.45 |
Polar | ICL1 | R | 86 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL1 | R | 86 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL3 | R | 252 | - | G.H5 | R | 372 | G.H5.17 |
Polar | TM6 | K | 260 | 6x30 | G.h4s6 | Y | 345 | G.h4s6.20 |
Aromatic | TM6 | K | 260 | 6x30 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM6 | K | 260 | 6x30 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM6 | K | 260 | 6x30 | G.h4s6 | Y | 345 | G.h4s6.20 |
Polar | ICL1 | K | 85 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL1 | K | 85 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL1 | K | 85 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL2 | T | 168 | - | G.HN | L | 37 | G.HN.52 |
Van-der-waals | ICL2 | T | 168 | - | G.HN | L | 37 | G.HN.52 |
Polar | H8 | K | 336 | 8x52 | G.h3s5 | T | 271 | G.h3s5.02 |
Hydrophobic | H8 | K | 336 | 8x52 | G.h3s5 | T | 271 | G.h3s5.02 |
Van-der-waals | H8 | K | 336 | 8x52 | G.h3s5 | T | 271 | G.h3s5.02 |
Hydrophobic | TM4 | K | 169 | 4x40 | G.HN | L | 37 | G.HN.52 |
Polar | TM3 | R | 152 | 3x50 | G.H5 | E | 379 | G.H5.24 |
Polar | ICL2 | T | 168 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | T | 168 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL2 | I | 160 | - | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL2 | I | 160 | - | G.H5 | Q | 371 | G.H5.16 |
Polar | H8 | N | 333 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | N | 333 | 8x49 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | N | 333 | 8x49 | G.H5 | E | 379 | G.H5.24 |