GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | T | 264 | 6x34 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 156 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Ionic | TM6 | K | 260 | 6x30 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 260 | 6x30 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | K | 260 | 6x30 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 260 | 6x30 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | F | 255 | - | G.H5 | D | 341 | G.H5.13 |
Polar | H8 | K | 336 | 8x52 | G.h4s6 | N | 316 | G.h4s6.10 |
Hydrophobic | H8 | K | 336 | 8x52 | G.h4s6 | N | 316 | G.h4s6.10 |
Van-der-waals | H8 | K | 336 | 8x52 | G.h4s6 | N | 316 | G.h4s6.10 |
Hydrophobic | ICL3 | F | 255 | - | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | ICL3 | F | 255 | - | G.H5 | D | 337 | G.H5.09 |
Polar | TM7 | M | 330 | 7x56 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM7 | M | 330 | 7x56 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM7 | M | 330 | 7x56 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 264 | 6x34 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | T | 264 | 6x34 | G.H5 | Y | 354 | G.H5.26 |
Ionic | ICL1 | K | 85 | - | G.h2s4 | D | 218 | G.h2s4.03 |
Polar | ICL1 | K | 85 | - | G.h2s4 | D | 218 | G.h2s4.03 |
Hydrophobic | ICL1 | K | 85 | - | G.h2s4 | D | 218 | G.h2s4.03 |
Van-der-waals | ICL1 | K | 85 | - | G.h2s4 | D | 218 | G.h2s4.03 |
Polar | ICL2 | R | 163 | - | G.S1 | D | 33 | G.S1.01 |
Van-der-waals | ICL2 | R | 163 | - | G.S1 | D | 33 | G.S1.01 |
Hydrophobic | H8 | K | 336 | 8x52 | G.h4s6 | P | 315 | G.h4s6.09 |
Polar | TM6 | K | 260 | 6x30 | G.h4s6 | P | 315 | G.h4s6.09 |
Polar | TM3 | K | 155 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | R | 152 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | I | 248 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | Y | 261 | 6x31 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | Y | 261 | 6x31 | G.H5 | L | 348 | G.H5.20 |
Ionic | ICL1 | R | 84 | - | G.h3s5 | D | 262 | G.h3s5.02 |
Polar | ICL1 | R | 84 | - | G.h3s5 | D | 262 | G.h3s5.02 |
Hydrophobic | ICL1 | R | 84 | - | G.h3s5 | D | 262 | G.h3s5.02 |
Van-der-waals | ICL1 | R | 84 | - | G.h3s5 | D | 262 | G.h3s5.02 |
Polar | H8 | N | 333 | 8x49 | G.h4s6 | N | 316 | G.h4s6.10 |
Van-der-waals | H8 | N | 333 | 8x49 | G.h4s6 | N | 316 | G.h4s6.10 |
Polar | ICL2 | R | 163 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | R | 163 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 163 | - | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL3 | N | 257 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | N | 257 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | I | 156 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | I | 160 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL3 | N | 257 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | N | 257 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | K | 260 | 6x30 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 260 | 6x30 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM3 | R | 152 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM3 | R | 152 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Polar | H8 | S | 331 | 8x47 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | H8 | S | 331 | 8x47 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | H8 | S | 331 | 8x47 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM6 | Y | 261 | 6x31 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | Y | 261 | 6x31 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | Y | 261 | 6x31 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | Y | 261 | 6x31 | G.H5 | Y | 354 | G.H5.26 |
Polar | H8 | S | 332 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | H8 | S | 332 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | H8 | S | 332 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Polar | ICL2 | Q | 161 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | ICL2 | Q | 161 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Polar | ICL3 | N | 257 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | N | 257 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | H8 | S | 331 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL3 | R | 252 | - | G.H5 | I | 344 | G.H5.16 |
Polar | TM2 | N | 87 | 2x37 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | TM2 | N | 87 | 2x37 | G.H5 | G | 350 | G.H5.22 |
Polar | TM6 | T | 264 | 6x34 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 264 | 6x34 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 264 | 6x34 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | R | 252 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL3 | R | 252 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM3 | I | 156 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Polar | TM7 | M | 330 | 7x56 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM7 | M | 330 | 7x56 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM7 | M | 330 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | M | 330 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Polar | ICL2 | Q | 161 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | Q | 161 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | Q | 161 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Polar | ICL3 | N | 257 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | N | 257 | - | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | ICL3 | N | 257 | - | G.H5 | Y | 354 | G.H5.26 |
Polar | ICL2 | R | 163 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | R | 163 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 163 | - | G.hns1 | K | 32 | G.hns1.03 |
Ionic | ICL3 | R | 252 | - | G.H5 | D | 337 | G.H5.09 |
Polar | ICL3 | R | 252 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL3 | R | 252 | - | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | ICL3 | R | 252 | - | G.H5 | D | 337 | G.H5.09 |
Polar | TM3 | R | 152 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 152 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 152 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | I | 160 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | I | 160 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM6 | S | 268 | 6x38 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | S | 268 | 6x38 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | Y | 261 | 6x31 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM6 | Y | 261 | 6x31 | G.H5 | I | 344 | G.H5.16 |
Polar | TM6 | Y | 261 | 6x31 | G.H5 | A | 345 | G.H5.17 |
Hydrophobic | TM6 | Y | 261 | 6x31 | G.H5 | A | 345 | G.H5.17 |
Hydrophobic | ICL2 | K | 164 | - | G.HN | I | 28 | G.HN.52 |
Van-der-waals | ICL2 | K | 164 | - | G.HN | I | 28 | G.HN.52 |
Hydrophobic | ICL2 | I | 160 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | I | 160 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM5 | L | 245 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | L | 245 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | F | 255 | - | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | TM2 | I | 89 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | I | 89 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | P | 256 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | P | 256 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | F | 255 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | F | 255 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL3 | N | 257 | - | G.H5 | A | 345 | G.H5.17 |
Ionic | ICL3 | R | 252 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | R | 252 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | R | 252 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | R | 252 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | P | 256 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM3 | K | 155 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | K | 155 | 3x53 | G.H5 | C | 351 | G.H5.23 |