G12 - GPR35 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 13.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 121 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 121 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL3 T 204 - G.S6 F 347 G.S6.02
Polar ICL2 R 125 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 125 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 125 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM1 F 45 1x57 G.H5 L 380 G.H5.25
Van-der-waals TM1 F 45 1x57 G.H5 L 380 G.H5.25
Van-der-waals TM4 Q 132 4x41 G.HN R 52 G.HN.52
Van-der-waals H8 E 282 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 122 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 122 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM5 R 201 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM2 M 59 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 M 59 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 118 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 118 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 122 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 122 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 122 34x51 G.H5 V 366 G.H5.11
Polar TM3 A 117 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 117 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 117 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 118 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 118 3x54 G.H5 L 371 G.H5.16
Ionic ICL2 R 128 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 128 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 128 34x57 G.H5 D 377 G.H5.22
Hydrophobic TM2 T 55 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM2 R 56 2x40 G.H5 L 380 G.H5.25
Polar TM4 S 129 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM4 S 129 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 S 129 4x38 G.hns1 R 55 G.hns1.02
Polar ICL2 R 125 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 125 34x54 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 125 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic TM6 A 215 6x33 G.H5 M 379 G.H5.24
Polar TM7 M 279 7x56 G.H5 Q 381 G.H5.26
Hydrophobic TM3 V 118 3x54 G.H5 L 375 G.H5.20
Polar TM3 R 114 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 114 3x50 G.H5 I 378 G.H5.23
Ionic TM5 R 201 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 201 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 201 5x68 G.H5 D 368 G.H5.13
Polar ICL2 G 126 34x55 G.HN R 52 G.HN.52
Hydrophobic ICL2 L 122 34x51 G.S3 F 223 G.S3.03
Hydrophobic ICL2 R 125 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 R 125 34x54 G.H5 I 370 G.H5.15
Polar TM6 Q 208 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Q 208 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Q 208 6x26 G.H5 Q 372 G.H5.17
Polar H8 K 281 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 R 123 34x52 G.S3 I 221 G.S3.01
Polar ICL2 R 128 34x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 122 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 122 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM5 L 198 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM6 K 214 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM3 A 117 3x53 G.H5 I 378 G.H5.23
Hydrophobic H8 A 280 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 A 280 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM6 M 218 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 M 218 6x36 G.H5 I 378 G.H5.23
Hydrophobic ICL1 M 49 12x48 G.H5 L 380 G.H5.25
Polar ICL2 G 126 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 G 126 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 G 126 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM4 R 131 4x40 G.HN R 51 G.HN.51
Van-der-waals TM4 R 131 4x40 G.HN R 51 G.HN.51
Hydrophobic TM6 M 218 6x36 G.H5 M 379 G.H5.24
Ionic ICL2 R 125 34x54 G.H5 E 373 G.H5.18
Polar ICL2 R 125 34x54 G.H5 E 373 G.H5.18
Polar H8 A 280 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 E 282 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 121 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 121 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM6 A 215 6x33 G.H5 L 375 G.H5.20
Hydrophobic H8 K 281 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM5 R 201 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 201 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM2 T 55 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 122 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM4 P 130 4x39 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 P 130 4x39 G.hns1 R 55 G.hns1.02
Polar TM6 D 205 6x23 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 D 205 6x23 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 P 121 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 122 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM6 A 211 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 211 6x29 G.H5 M 379 G.H5.24
Hydrophobic TM6 K 214 6x32 G.H5 M 379 G.H5.24
Polar TM2 T 53 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 T 53 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 T 53 2x37 G.H5 D 377 G.H5.22
Polar TM2 T 55 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM2 T 55 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 T 55 2x39 G.H5 D 377 G.H5.22