GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 10.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | F | 141 | 34x51 | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | F | 141 | 34x51 | G.S3 | I | 195 | G.S3.01 |
Hydrophobic | ICL3 | R | 267 | - | G.S6 | F | 324 | G.S6.05 |
Hydrophobic | C-term | V | 376 | - | G.h3s5 | L | 261 | G.h3s5.01 |
Hydrophobic | TM3 | A | 136 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | A | 136 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | I | 137 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | C-term | L | 393 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | L | 393 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | L | 392 | - | G.H2 | W | 212 | G.H2.07 |
Hydrophobic | C-term | L | 392 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | ICL2 | F | 141 | 34x51 | G.H5 | K | 341 | G.H5.12 |
Van-der-waals | ICL2 | F | 141 | 34x51 | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | C-term | L | 393 | - | G.H2 | R | 210 | G.H2.05 |
Hydrophobic | ICL2 | F | 141 | 34x51 | G.S1 | L | 36 | G.S1.02 |
Van-der-waals | ICL2 | F | 141 | 34x51 | G.S1 | L | 36 | G.S1.02 |
Polar | ICL1 | Q | 65 | - | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | ICL1 | Q | 65 | - | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | ICL1 | Q | 65 | - | G.H5 | E | 351 | G.H5.22 |
Polar | ICL2 | K | 144 | 34x54 | G.S1 | E | 35 | G.S1.01 |
Hydrophobic | TM2 | V | 68 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM2 | V | 68 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Ionic | TM6 | R | 278 | 6x30 | G.H5 | D | 342 | G.H5.13 |
Polar | C-term | K | 372 | - | G.h3s5 | L | 261 | G.h3s5.01 |
Hydrophobic | C-term | K | 372 | - | G.h3s5 | L | 261 | G.h3s5.01 |
Van-der-waals | C-term | K | 372 | - | G.h3s5 | L | 261 | G.h3s5.01 |
Hydrophobic | TM6 | A | 277 | 6x29 | G.H5 | V | 355 | G.H5.26 |
Ionic | C-term | R | 375 | - | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | C-term | R | 375 | - | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | C-term | R | 375 | - | G.h4s6 | E | 317 | G.h4s6.12 |
Van-der-waals | C-term | R | 375 | - | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | ICL1 | L | 64 | - | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | K | 144 | 34x54 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL2 | K | 144 | 34x54 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM5 | L | 249 | 5x68 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | F | 284 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | F | 284 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Ionic | ICL3 | K | 268 | - | G.H5 | D | 342 | G.H5.13 |
Polar | ICL3 | K | 268 | - | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | ICL3 | K | 268 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Polar | C-term | R | 390 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | V | 376 | - | G.h4s6 | D | 315 | G.h4s6.10 |
Polar | C-term | K | 372 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Van-der-waals | C-term | K | 372 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Hydrophobic | TM3 | E | 132 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Polar | H8 | S | 348 | 8x47 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | H8 | S | 348 | 8x47 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | H8 | S | 348 | 8x47 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | ICL2 | P | 140 | 34x50 | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | ICL1 | L | 64 | - | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL3 | L | 266 | - | G.H5 | A | 339 | G.H5.10 |
Polar | ICL2 | K | 144 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 |
Polar | C-term | N | 369 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Polar | C-term | L | 392 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | L | 392 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | ICL3 | L | 266 | - | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | ICL3 | L | 266 | - | G.S6 | Y | 321 | G.S6.02 |
Polar | H8 | S | 348 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | H8 | S | 348 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | H8 | S | 348 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Polar | H8 | Q | 349 | 8x48 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | C-term | L | 392 | - | G.H3 | L | 250 | G.H3.08 |
Polar | TM7 | S | 347 | 7x56 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | C-term | L | 392 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | L | 392 | - | G.H2 | R | 209 | G.H2.04 |
Polar | TM3 | A | 136 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | A | 136 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | A | 136 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | Y | 143 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | I | 137 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL3 | L | 266 | - | G.H5 | A | 338 | G.H5.09 |
Polar | ICL2 | S | 147 | 34x57 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL2 | S | 147 | 34x57 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM5 | V | 248 | 5x67 | G.H5 | L | 345 | G.H5.16 |
Polar | ICL2 | A | 145 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL2 | A | 145 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | TM5 | L | 257 | 5x76 | G.H5 | A | 338 | G.H5.09 |
Van-der-waals | TM5 | L | 257 | 5x76 | G.H5 | A | 338 | G.H5.09 |
Polar | ICL3 | R | 267 | - | G.S6 | S | 322 | G.S6.03 |
Van-der-waals | ICL3 | R | 267 | - | G.S6 | S | 322 | G.S6.03 |
Polar | TM6 | T | 281 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | T | 281 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | T | 281 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Ionic | ICL3 | R | 267 | - | G.H4 | D | 303 | G.H4.09 |
Polar | ICL3 | R | 267 | - | G.H4 | D | 303 | G.H4.09 |
Van-der-waals | ICL3 | R | 267 | - | G.H4 | D | 303 | G.H4.09 |
Polar | ICL3 | S | 269 | - | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | ICL3 | S | 269 | - | G.S6 | I | 320 | G.S6.01 |
Polar | C-term | S | 396 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Hydrophobic | C-term | S | 396 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Van-der-waals | C-term | S | 396 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Hydrophobic | C-term | R | 373 | - | G.h3s5 | L | 261 | G.h3s5.01 |
Hydrophobic | C-term | L | 392 | - | G.H3 | T | 253 | G.H3.11 |
Van-der-waals | TM1 | L | 58 | 1x60 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL3 | K | 268 | - | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | ICL3 | K | 268 | - | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | ICL3 | K | 268 | - | G.H5 | Q | 346 | G.H5.17 |
Aromatic | ICL2 | F | 141 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | ICL2 | F | 141 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | F | 141 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Polar | TM7 | S | 347 | 7x56 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | ICL2 | F | 141 | 34x51 | G.S3 | F | 197 | G.S3.03 |
Hydrophobic | ICL3 | L | 266 | - | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | ICL3 | L | 266 | - | G.H5 | F | 335 | G.H5.06 |
Polar | C-term | S | 396 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | ICL2 | F | 141 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | F | 141 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | H8 | F | 351 | 8x50 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL3 | K | 268 | - | G.h4s6 | V | 319 | G.h4s6.20 |
Van-der-waals | ICL3 | K | 268 | - | G.h4s6 | V | 319 | G.h4s6.20 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 133 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Polar | C-term | H | 379 | - | G.h4s6 | P | 314 | G.h4s6.09 |
Hydrophobic | C-term | H | 379 | - | G.h4s6 | P | 314 | G.h4s6.09 |
Van-der-waals | C-term | H | 379 | - | G.h4s6 | P | 314 | G.h4s6.09 |
Hydrophobic | ICL2 | K | 144 | 34x54 | G.S1 | L | 36 | G.S1.02 |
Van-der-waals | ICL2 | K | 144 | 34x54 | G.S1 | L | 36 | G.S1.02 |
Hydrophobic | TM3 | I | 137 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM7 | S | 347 | 7x56 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | Y | 143 | 34x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | ICL2 | Y | 143 | 34x53 | G.H5 | F | 352 | G.H5.23 |
Polar | TM5 | S | 252 | 5x71 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | S | 252 | 5x71 | G.H5 | D | 342 | G.H5.13 |
Polar | H8 | Q | 350 | 8x49 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | C-term | V | 376 | - | G.H3 | T | 256 | G.H3.14 |
Ionic | C-term | D | 383 | - | G.H3 | K | 252 | G.H3.10 |
Hydrophobic | ICL2 | P | 140 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 140 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | F | 141 | 34x51 | G.H5 | V | 340 | G.H5.11 |