Gs - GPR39 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 Y 143 34x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Y 143 34x53 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 Y 143 34x53 G.H5 Y 391 G.H5.23
Polar TM3 I 137 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 137 3x54 G.H5 Q 384 G.H5.16
Polar C-term K 372 - G.H3 W 281 G.H3.17
Hydrophobic ICL3 L 266 - G.S6 P 361 G.S6.03
Hydrophobic ICL1 L 64 - G.H5 Q 390 G.H5.22
Van-der-waals ICL1 L 64 - G.H5 Q 390 G.H5.22
Hydrophobic ICL2 F 141 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 141 34x51 G.H5 I 383 G.H5.15
Hydrophobic C-term V 376 - G.h3s5 R 283 G.h3s5.01
Hydrophobic ICL3 S 269 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 L 266 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 L 266 - G.H4 R 342 G.H4.12
Hydrophobic ICL2 F 141 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 141 34x51 G.S3 V 217 G.S3.01
Polar TM5 S 252 5x71 G.H5 D 381 G.H5.13
Hydrophobic C-term H 379 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term H 379 - G.h3s5 R 283 G.h3s5.01
Hydrophobic ICL3 K 268 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 K 268 - G.S6 Y 360 G.S6.02
Polar H8 F 351 8x50 G.H5 E 392 G.H5.24
Hydrophobic H8 F 351 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 F 351 8x50 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 141 34x51 G.S3 F 219 G.S3.03
Hydrophobic ICL2 K 144 34x54 G.H5 H 387 G.H5.19
Polar TM6 T 281 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 T 281 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 281 6x33 G.H5 L 393 G.H5.25
Hydrophobic C-term R 375 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term R 375 - G.h4s6 R 356 G.h4s6.12
Ionic C-term D 383 - G.h3s5 R 283 G.h3s5.01
Polar C-term D 383 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term D 383 - G.h3s5 R 283 G.h3s5.01
Hydrophobic H8 Q 350 8x49 G.H5 E 392 G.H5.24
Hydrophobic ICL3 P 264 - G.hgh4 T 325 G.hgh4.15
Hydrophobic TM7 S 347 7x56 G.H5 L 393 G.H5.25
Polar C-term K 372 - G.h3s5 T 284 G.h3s5.02
Hydrophobic C-term K 372 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term K 372 - G.h3s5 T 284 G.h3s5.02
Hydrophobic TM3 A 136 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL3 P 263 - G.hgh4 T 325 G.hgh4.15
Van-der-waals ICL3 P 263 - G.hgh4 T 325 G.hgh4.15
Ionic TM2 E 67 2x38 G.hns1 R 38 G.hns1.02
Polar TM2 E 67 2x38 G.hns1 R 38 G.hns1.02
Van-der-waals TM2 E 67 2x38 G.hns1 R 38 G.hns1.02
Aromatic ICL2 Y 143 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 143 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 143 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 I 137 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 137 3x54 G.H5 L 388 G.H5.20
Polar TM5 S 252 5x71 G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 140 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 V 248 5x67 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 248 5x67 G.H5 Q 384 G.H5.16
Polar ICL3 Q 265 - G.S6 H 362 G.S6.04
Hydrophobic ICL3 Q 265 - G.S6 H 362 G.S6.04
Van-der-waals ICL3 Q 265 - G.S6 H 362 G.S6.04
Hydrophobic ICL1 L 64 - G.H5 E 392 G.H5.24
Hydrophobic TM6 F 284 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 F 284 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Polar TM3 E 132 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 E 132 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 132 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM1 L 58 1x60 G.H5 E 392 G.H5.24
Van-der-waals TM1 L 58 1x60 G.H5 E 392 G.H5.24
Ionic C-term R 375 - G.h4s6 D 354 G.h4s6.10
Polar C-term R 375 - G.h4s6 D 354 G.h4s6.10
Van-der-waals C-term R 375 - G.h4s6 D 354 G.h4s6.10
Hydrophobic ICL3 L 266 - G.S6 F 363 G.S6.05
Aromatic ICL2 F 141 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 141 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 141 34x51 G.H5 F 376 G.H5.08
Polar ICL2 S 147 34x57 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 S 147 34x57 G.hns1 R 38 G.hns1.02
Ionic ICL3 E 270 - G.H5 R 385 G.H5.17
Polar ICL3 E 270 - G.H5 R 385 G.H5.17
Hydrophobic ICL3 E 270 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 E 270 - G.H5 R 385 G.H5.17
Hydrophobic TM2 V 68 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 V 68 2x39 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 141 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 141 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 141 34x51 G.S1 H 41 G.S1.02
Ionic ICL3 K 268 - G.H5 D 381 G.H5.13
Polar ICL3 K 268 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 K 268 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 K 268 - G.H5 D 381 G.H5.13
Hydrophobic TM6 S 274 6x26 G.H5 L 394 G.H5.26
Polar TM7 S 347 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 S 347 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL2 P 140 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 140 34x50 G.H5 R 380 G.H5.12
Polar H8 S 348 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 348 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 348 8x47 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 141 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 P 140 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 140 34x50 G.H5 I 383 G.H5.15
Polar ICL2 K 144 34x54 G.S1 H 41 G.S1.02
Aromatic ICL2 K 144 34x54 G.S1 H 41 G.S1.02
Hydrophobic ICL2 K 144 34x54 G.S1 H 41 G.S1.02
Van-der-waals ICL2 K 144 34x54 G.S1 H 41 G.S1.02
Ionic ICL3 R 262 - G.H5 E 370 G.H5.02
Polar ICL3 R 262 - G.H5 E 370 G.H5.02
Hydrophobic ICL3 R 262 - G.H5 E 370 G.H5.02
Van-der-waals ICL3 R 262 - G.H5 E 370 G.H5.02
Hydrophobic TM6 A 277 6x29 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 141 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 141 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM3 I 137 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 249 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL3 K 268 - G.H5 R 385 G.H5.17
Ionic C-term H 379 - G.h4s6 D 354 G.h4s6.10
Polar C-term H 379 - G.h4s6 D 354 G.h4s6.10
Polar TM3 A 136 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 136 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 136 3x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 A 145 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 A 145 34x55 G.hns1 A 39 G.hns1.03
Ionic C-term E 371 - G.h4s6 R 356 G.h4s6.12
Polar C-term E 371 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term E 371 - G.h4s6 R 356 G.h4s6.12
Polar C-term K 372 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term K 372 - G.h2s4 N 239 G.h2s4.02
Polar ICL1 Q 65 - G.H5 Q 390 G.H5.22
Hydrophobic ICL1 Q 65 - G.H5 Q 390 G.H5.22
Van-der-waals ICL1 Q 65 - G.H5 Q 390 G.H5.22
Hydrophobic ICL2 P 140 34x50 G.H5 H 387 G.H5.19
Van-der-waals ICL2 P 140 34x50 G.H5 H 387 G.H5.19
Hydrophobic C-term V 376 - G.H3 R 280 G.H3.16
Van-der-waals C-term V 376 - G.H3 R 280 G.H3.16
Ionic ICL3 K 268 - G.H5 D 378 G.H5.10
Polar ICL2 K 144 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 K 144 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 144 34x54 G.hns1 R 38 G.hns1.02
Polar ICL2 K 144 34x54 G.S1 T 40 G.S1.01
Van-der-waals ICL2 K 144 34x54 G.S1 T 40 G.S1.01