GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | ICL3 | K | 268 | - | G.H5 | D | 337 | G.H5.13 |
Polar | ICL3 | K | 268 | - | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | ICL3 | K | 268 | - | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM3 | I | 137 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | I | 137 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Aromatic | C-term | F | 413 | - | G.H3 | H | 252 | G.H3.15 |
Hydrophobic | C-term | F | 413 | - | G.H3 | H | 252 | G.H3.15 |
Hydrophobic | C-term | F | 413 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | ICL2 | F | 141 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | ICL2 | Y | 143 | 34x53 | G.H5 | N | 343 | G.H5.19 |
Polar | ICL1 | Q | 65 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL1 | Q | 65 | - | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | ICL1 | Q | 65 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL2 | K | 144 | 34x54 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | K | 144 | 34x54 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL3 | L | 266 | - | G.H5 | D | 333 | G.H5.09 |
Hydrophobic | H8 | S | 348 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | H8 | S | 348 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | ICL3 | L | 266 | - | G.H5 | A | 334 | G.H5.10 |
Polar | ICL3 | R | 267 | - | G.S6 | S | 317 | G.S6.03 |
Van-der-waals | ICL3 | R | 267 | - | G.S6 | S | 317 | G.S6.03 |
Polar | H8 | S | 348 | 8x47 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | H8 | S | 348 | 8x47 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | H8 | S | 348 | 8x47 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | ICL1 | L | 64 | - | G.H5 | C | 347 | G.H5.23 |
Polar | TM3 | A | 136 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | A | 136 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM3 | A | 136 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | P | 140 | 34x50 | G.H5 | T | 336 | G.H5.12 |
Ionic | C-term | R | 375 | - | G.h4s6 | D | 311 | G.h4s6.09 |
Polar | C-term | R | 375 | - | G.h4s6 | D | 311 | G.h4s6.09 |
Aromatic | C-term | H | 379 | - | G.h4s6 | R | 309 | G.h4s6.04 |
Hydrophobic | C-term | H | 379 | - | G.h4s6 | R | 309 | G.h4s6.04 |
Van-der-waals | C-term | H | 379 | - | G.h4s6 | R | 309 | G.h4s6.04 |
Hydrophobic | ICL2 | F | 141 | 34x51 | G.H5 | T | 336 | G.H5.12 |
Van-der-waals | ICL2 | F | 141 | 34x51 | G.H5 | T | 336 | G.H5.12 |
Hydrophobic | C-term | F | 413 | - | G.H2 | W | 207 | G.H2.07 |
Hydrophobic | C-term | L | 410 | - | G.H2 | R | 201 | G.H2.01 |
Hydrophobic | ICL3 | L | 266 | - | G.S6 | S | 317 | G.S6.03 |
Hydrophobic | TM6 | S | 271 | 6x23 | G.h4s6 | R | 310 | G.h4s6.08 |
Van-der-waals | TM6 | S | 271 | 6x23 | G.h4s6 | R | 310 | G.h4s6.08 |
Hydrophobic | TM3 | A | 136 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | A | 136 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL1 | L | 64 | - | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | ICL1 | L | 64 | - | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | ICL3 | L | 266 | - | G.S6 | H | 318 | G.S6.04 |
Ionic | ICL2 | K | 144 | 34x54 | G.H5 | E | 342 | G.H5.18 |
Polar | ICL2 | K | 144 | 34x54 | G.H5 | E | 342 | G.H5.18 |
Van-der-waals | ICL2 | K | 144 | 34x54 | G.H5 | E | 342 | G.H5.18 |
Hydrophobic | TM6 | S | 274 | 6x26 | G.H5 | F | 350 | G.H5.26 |
Polar | TM6 | S | 274 | 6x26 | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | TM6 | S | 274 | 6x26 | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | TM5 | S | 252 | 5x71 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM5 | S | 252 | 5x71 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM5 | S | 252 | 5x71 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM5 | L | 249 | 5x68 | G.H5 | L | 344 | G.H5.20 |
Aromatic | C-term | F | 394 | - | G.H3 | H | 240 | G.H3.03 |
Hydrophobic | C-term | F | 394 | - | G.H3 | H | 240 | G.H3.03 |
Van-der-waals | C-term | F | 394 | - | G.H3 | H | 240 | G.H3.03 |
Hydrophobic | TM5 | L | 249 | 5x68 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | ICL3 | S | 269 | - | G.H4 | L | 304 | G.H4.16 |
Polar | ICL3 | R | 267 | - | G.H4 | K | 300 | G.H4.12 |
Hydrophobic | ICL3 | R | 267 | - | G.H4 | K | 300 | G.H4.12 |
Van-der-waals | ICL3 | R | 267 | - | G.H4 | K | 300 | G.H4.12 |
Hydrophobic | TM6 | A | 277 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | A | 277 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Ionic | ICL2 | R | 142 | 34x52 | G.s2s3 | D | 189 | G.s2s3.02 |
Hydrophobic | TM6 | T | 281 | 6x33 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | ICL2 | F | 141 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | F | 141 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | ICL2 | A | 145 | 34x55 | G.HN | E | 24 | G.HN.52 |
Van-der-waals | ICL2 | A | 145 | 34x55 | G.HN | E | 24 | G.HN.52 |
Polar | TM3 | R | 133 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Polar | TM7 | S | 347 | 7x56 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM7 | S | 347 | 7x56 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | ICL2 | F | 141 | 34x51 | G.H5 | F | 332 | G.H5.08 |
Hydrophobic | ICL2 | A | 145 | 34x55 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | TM2 | V | 68 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Polar | C-term | R | 375 | - | G.h4s6 | R | 309 | G.h4s6.04 |
Van-der-waals | TM4 | Q | 151 | 4x41 | G.HN | K | 20 | G.HN.48 |
Polar | TM6 | T | 281 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM6 | T | 281 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | T | 281 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL3 | L | 266 | - | G.S6 | Y | 316 | G.S6.02 |
Van-der-waals | ICL3 | L | 266 | - | G.S6 | Y | 316 | G.S6.02 |
Polar | TM6 | S | 271 | 6x23 | G.h4s6 | D | 311 | G.h4s6.09 |
Hydrophobic | TM6 | S | 271 | 6x23 | G.h4s6 | D | 311 | G.h4s6.09 |
Van-der-waals | TM6 | S | 271 | 6x23 | G.h4s6 | D | 311 | G.h4s6.09 |
Hydrophobic | ICL3 | L | 266 | - | G.H5 | F | 330 | G.H5.06 |
Van-der-waals | ICL3 | L | 266 | - | G.H5 | F | 330 | G.H5.06 |
Hydrophobic | ICL1 | L | 64 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL2 | P | 140 | 34x50 | G.H5 | I | 339 | G.H5.15 |
Polar | TM7 | S | 347 | 7x56 | G.H5 | F | 350 | G.H5.26 |
Polar | ICL3 | P | 264 | - | G.S6 | H | 318 | G.S6.04 |
Hydrophobic | ICL3 | P | 264 | - | G.S6 | H | 318 | G.S6.04 |
Van-der-waals | ICL3 | P | 264 | - | G.S6 | H | 318 | G.S6.04 |
Hydrophobic | C-term | D | 383 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Van-der-waals | C-term | D | 383 | - | G.h4s6 | M | 308 | G.h4s6.03 |
Hydrophobic | ICL3 | Q | 265 | - | G.H5 | F | 330 | G.H5.06 |
Hydrophobic | ICL2 | P | 140 | 34x50 | G.H5 | I | 340 | G.H5.16 |
Ionic | ICL3 | K | 268 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | ICL3 | K | 268 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | ICL3 | K | 268 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | ICL3 | K | 268 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | TM7 | S | 347 | 7x56 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM7 | S | 347 | 7x56 | G.H5 | L | 349 | G.H5.25 |
Polar | ICL2 | P | 140 | 34x50 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | P | 140 | 34x50 | G.H5 | N | 343 | G.H5.19 |
Polar | ICL3 | K | 268 | - | G.S6 | Y | 316 | G.S6.02 |
Hydrophobic | ICL3 | K | 268 | - | G.S6 | Y | 316 | G.S6.02 |
Van-der-waals | ICL3 | K | 268 | - | G.S6 | Y | 316 | G.S6.02 |
Polar | ICL3 | S | 269 | - | G.S6 | I | 315 | G.S6.01 |
Van-der-waals | ICL3 | S | 269 | - | G.S6 | I | 315 | G.S6.01 |
Polar | ICL3 | R | 267 | - | G.H4 | N | 297 | G.H4.08 |
Van-der-waals | ICL3 | R | 267 | - | G.H4 | N | 297 | G.H4.08 |
Hydrophobic | ICL3 | P | 264 | - | G.H5 | F | 330 | G.H5.06 |
Van-der-waals | ICL3 | P | 264 | - | G.H5 | F | 330 | G.H5.06 |
Hydrophobic | C-term | V | 376 | - | G.H3 | R | 253 | G.H3.16 |
Polar | ICL2 | Y | 143 | 34x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | Y | 143 | 34x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | I | 137 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM6 | F | 284 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | F | 284 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | C-term | V | 376 | - | G.h3s5 | A | 256 | G.h3s5.01 |
Hydrophobic | TM5 | V | 248 | 5x67 | G.H5 | I | 340 | G.H5.16 |
Polar | TM6 | S | 274 | 6x26 | G.H5 | K | 341 | G.H5.17 |
Hydrophobic | TM6 | S | 274 | 6x26 | G.H5 | K | 341 | G.H5.17 |
Van-der-waals | TM6 | S | 274 | 6x26 | G.H5 | K | 341 | G.H5.17 |