G11 - GPR45 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 K 262 6x30 G.H5 K 354 G.H5.21
Polar ICL3 Q 253 - G.S6 S 326 G.S6.03
Polar ICL3 Q 250 - G.S6 H 327 G.S6.04
Hydrophobic ICL3 Q 250 - G.S6 H 327 G.S6.04
Van-der-waals ICL3 Q 250 - G.S6 H 327 G.S6.04
Polar TM2 N 70 2x40 G.H5 L 358 G.H5.25
Hydrophobic TM2 N 70 2x40 G.H5 L 358 G.H5.25
Van-der-waals TM2 N 70 2x40 G.H5 L 358 G.H5.25
Polar C-term P 359 - G.S3 R 202 G.S3.04
Hydrophobic C-term P 359 - G.S3 R 202 G.S3.04
Van-der-waals C-term P 359 - G.S3 R 202 G.S3.04
Hydrophobic C-term Y 363 - G.S2 E 191 G.S2.03
Hydrophobic TM1 V 55 1x53 G.H5 L 358 G.H5.25
Hydrophobic ICL1 M 65 12x50 G.H5 Y 356 G.H5.23
Hydrophobic TM2 N 70 2x40 G.H5 N 357 G.H5.24
Van-der-waals TM2 N 70 2x40 G.H5 N 357 G.H5.24
Hydrophobic H8 F 331 8x50 G.H5 L 358 G.H5.25
Polar C-term C 365 - G.S2 I 189 G.S2.01
Hydrophobic C-term C 365 - G.S2 I 189 G.S2.01
Van-der-waals C-term C 365 - G.S2 I 189 G.S2.01
Hydrophobic TM2 L 73 2x43 G.H5 V 359 G.H5.26
Van-der-waals TM2 L 73 2x43 G.H5 V 359 G.H5.26
Polar ICL1 R 66 12x51 G.hns1 R 37 G.hns1.02
Hydrophobic ICL1 R 66 12x51 G.hns1 R 37 G.hns1.02
Van-der-waals ICL1 R 66 12x51 G.hns1 R 37 G.hns1.02
Aromatic H8 K 330 8x49 G.H5 Y 356 G.H5.23
Polar C-term Y 363 - G.H2 H 218 G.H2.09
Hydrophobic TM6 I 269 6x37 G.H5 V 359 G.H5.26
Van-der-waals TM6 I 269 6x37 G.H5 V 359 G.H5.26
Polar TM2 N 70 2x40 G.H5 Y 356 G.H5.23
Hydrophobic TM2 N 70 2x40 G.H5 Y 356 G.H5.23
Van-der-waals TM2 N 70 2x40 G.H5 Y 356 G.H5.23
Polar C-term R 355 - G.h2s4 V 223 G.h2s4.04
Hydrophobic C-term R 355 - G.h2s4 V 223 G.h2s4.04
Van-der-waals C-term R 355 - G.h2s4 V 223 G.h2s4.04
Hydrophobic TM2 I 69 2x39 G.H5 V 359 G.H5.26
Van-der-waals TM2 I 69 2x39 G.H5 V 359 G.H5.26
Polar C-term Q 369 - G.hfs2 T 187 G.hfs2.06
Hydrophobic C-term Q 369 - G.hfs2 T 187 G.hfs2.06
Van-der-waals C-term Q 369 - G.hfs2 T 187 G.hfs2.06
Hydrophobic C-term R 352 - G.h3s5 N 266 G.h3s5.02
Van-der-waals C-term R 352 - G.h3s5 N 266 G.h3s5.02
Hydrophobic TM2 L 73 2x43 G.H5 L 358 G.H5.25
Van-der-waals TM2 L 73 2x43 G.H5 L 358 G.H5.25
Hydrophobic H8 I 328 8x47 G.H5 L 358 G.H5.25
Van-der-waals H8 I 328 8x47 G.H5 L 358 G.H5.25
Polar ICL3 Q 254 - G.H5 A 343 G.H5.10
Hydrophobic ICL3 Q 254 - G.H5 A 343 G.H5.10
Van-der-waals ICL3 Q 254 - G.H5 A 343 G.H5.10
Ionic H8 K 330 8x49 G.H5 E 355 G.H5.22
Polar H8 K 330 8x49 G.H5 E 355 G.H5.22
Hydrophobic H8 K 330 8x49 G.H5 E 355 G.H5.22
Van-der-waals H8 K 330 8x49 G.H5 E 355 G.H5.22
Hydrophobic ICL1 M 65 12x50 G.H5 L 358 G.H5.25
Hydrophobic ICL3 L 238 - G.H4 R 306 G.H4.08
Hydrophobic TM6 F 261 6x29 G.H5 K 354 G.H5.21
Van-der-waals TM6 F 261 6x29 G.H5 K 354 G.H5.21
Van-der-waals ICL2 D 141 - G.H5 L 353 G.H5.20
Hydrophobic TM7 Y 324 7x53 G.H5 V 359 G.H5.26
Polar C-term V 372 - H.hbhc E 119 H.hbhc.01
Hydrophobic C-term V 372 - H.hbhc E 119 H.hbhc.01
Van-der-waals C-term V 372 - H.hbhc E 119 H.hbhc.01
Polar TM2 S 67 2x37 G.H5 Y 356 G.H5.23
Hydrophobic TM6 V 257 6x25 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 V 257 6x25 G.h4s6 I 323 G.h4s6.20
Ionic TM6 D 258 6x26 G.H5 K 354 G.H5.21
Polar TM6 D 258 6x26 G.H5 K 354 G.H5.21
Van-der-waals TM6 D 258 6x26 G.H5 K 354 G.H5.21
Hydrophobic TM2 I 69 2x39 G.H5 N 357 G.H5.24
Van-der-waals TM2 I 69 2x39 G.H5 N 357 G.H5.24
Hydrophobic H8 I 328 8x47 G.H5 V 359 G.H5.26
Hydrophobic C-term R 355 - G.h2s4 E 221 G.h2s4.02
Polar TM6 D 258 6x26 G.H5 Q 350 G.H5.17
Hydrophobic TM6 D 258 6x26 G.H5 Q 350 G.H5.17
Van-der-waals TM6 D 258 6x26 G.H5 Q 350 G.H5.17
Polar C-term R 355 - G.h3s5 S 267 G.h3s5.03
Van-der-waals C-term R 355 - G.h3s5 S 267 G.h3s5.03
Polar TM2 S 67 2x37 G.H5 N 357 G.H5.24
Van-der-waals TM2 S 67 2x37 G.H5 N 357 G.H5.24
Polar C-term R 355 - G.h2s4 N 222 G.h2s4.03
Hydrophobic C-term R 355 - G.h2s4 N 222 G.h2s4.03
Van-der-waals C-term R 355 - G.h2s4 N 222 G.h2s4.03
Polar ICL1 P 63 12x48 G.hns1 R 37 G.hns1.02
Hydrophobic ICL1 P 63 12x48 G.hns1 R 37 G.hns1.02
Van-der-waals ICL1 P 63 12x48 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 A 265 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 A 265 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM6 V 257 6x25 G.S6 Y 325 G.S6.02
Van-der-waals TM6 V 257 6x25 G.S6 Y 325 G.S6.02
Polar TM6 V 257 6x25 G.H5 K 354 G.H5.21
Hydrophobic ICL1 P 63 12x48 G.HN K 33 G.HN.51
Polar C-term R 356 - G.h2s4 E 221 G.h2s4.02
Van-der-waals C-term R 356 - G.h2s4 E 221 G.h2s4.02
Hydrophobic ICL1 A 64 12x49 G.H5 Y 356 G.H5.23
Van-der-waals ICL1 A 64 12x49 G.H5 Y 356 G.H5.23
Hydrophobic TM6 S 260 6x28 G.h4s6 I 323 G.h4s6.20
Hydrophobic C-term I 353 - G.H3 W 263 G.H3.17
Van-der-waals C-term I 353 - G.H3 W 263 G.H3.17
Hydrophobic C-term I 357 - G.h2s4 N 222 G.h2s4.03
Van-der-waals C-term I 357 - G.h2s4 N 222 G.h2s4.03
Hydrophobic TM1 V 59 1x57 G.H5 L 358 G.H5.25
Hydrophobic C-term C 365 - G.S2 I 190 G.S2.02
Van-der-waals C-term C 365 - G.S2 I 190 G.S2.02
Polar C-term R 355 - G.H3 W 263 G.H3.17
Van-der-waals C-term R 355 - G.H3 W 263 G.H3.17
Hydrophobic C-term A 371 - H.hbhc E 119 H.hbhc.01
Van-der-waals C-term A 371 - H.hbhc E 119 H.hbhc.01
Hydrophobic ICL3 Q 250 - G.H5 F 339 G.H5.06
Van-der-waals ICL3 Q 250 - G.H5 F 339 G.H5.06
Hydrophobic TM6 T 268 6x36 G.H5 V 359 G.H5.26
Polar ICL1 A 64 12x49 G.hns1 R 37 G.hns1.02
Hydrophobic ICL1 A 64 12x49 G.hns1 R 37 G.hns1.02
Van-der-waals ICL1 A 64 12x49 G.hns1 R 37 G.hns1.02
Polar TM3 R 132 3x50 G.H5 V 359 G.H5.26
Van-der-waals TM3 R 132 3x50 G.H5 V 359 G.H5.26