G12 - GPR45 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 75.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL2 D 141 - G.hns1 R 56 G.hns1.03
Polar ICL2 D 141 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 D 141 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 D 141 - G.hns1 R 56 G.hns1.03
Aromatic ICL3 R 239 - G.H5 F 361 G.H5.06
Hydrophobic ICL3 R 239 - G.H5 F 361 G.H5.06
Polar C-term R 355 - G.H3 L 285 G.H3.17
Hydrophobic C-term R 355 - G.H3 L 285 G.H3.17
Van-der-waals C-term R 355 - G.H3 L 285 G.H3.17
Hydrophobic TM6 A 265 6x33 G.H5 L 380 G.H5.25
Hydrophobic ICL3 L 238 - G.H4 Q 328 G.H4.08
Van-der-waals ICL3 L 238 - G.H4 Q 328 G.H4.08
Polar TM2 N 70 2x40 G.H5 Q 381 G.H5.26
Hydrophobic TM2 N 70 2x40 G.H5 Q 381 G.H5.26
Van-der-waals TM2 N 70 2x40 G.H5 Q 381 G.H5.26
Hydrophobic TM6 D 258 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 D 258 6x26 G.H5 D 368 G.H5.13
Polar ICL3 Q 254 - G.H5 V 362 G.H5.07
Polar TM6 D 258 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 D 258 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 D 258 6x26 G.H5 Q 372 G.H5.17
Polar ICL3 Q 254 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 Q 254 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 Q 254 - G.S6 H 349 G.S6.04
Polar ICL2 K 142 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 142 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 142 - G.hns1 R 56 G.hns1.03
Hydrophobic C-term I 357 - G.H3 L 285 G.H3.17
Van-der-waals C-term I 357 - G.H3 L 285 G.H3.17
Hydrophobic ICL3 R 251 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 R 251 - G.H5 F 361 G.H5.06
Hydrophobic TM6 F 261 6x29 G.H5 E 373 G.H5.18
Van-der-waals TM6 F 261 6x29 G.H5 E 373 G.H5.18
Hydrophobic TM2 I 69 2x39 G.H5 M 379 G.H5.24
Van-der-waals TM2 I 69 2x39 G.H5 M 379 G.H5.24
Hydrophobic TM4 P 145 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 P 145 4x39 G.HN R 52 G.HN.52
Polar TM6 K 262 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM6 K 262 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 K 262 6x30 G.H5 Q 372 G.H5.17
Hydrophobic ICL3 L 238 - G.S6 F 350 G.S6.05
Hydrophobic H8 K 329 8x48 G.h3s5 F 287 G.h3s5.01
Van-der-waals H8 K 329 8x48 G.h3s5 F 287 G.h3s5.01
Hydrophobic TM4 R 146 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 R 146 4x40 G.HN R 52 G.HN.52
Polar TM6 F 261 6x29 G.H5 K 376 G.H5.21
Hydrophobic TM6 F 261 6x29 G.H5 K 376 G.H5.21
Van-der-waals TM6 F 261 6x29 G.H5 K 376 G.H5.21
Polar C-term Y 363 - G.H2 Q 236 G.H2.05
Van-der-waals C-term Y 363 - G.H2 Q 236 G.H2.05
Polar C-term C 365 - G.H2 Q 236 G.H2.05
Hydrophobic C-term C 365 - G.H2 Q 236 G.H2.05
Van-der-waals C-term C 365 - G.H2 Q 236 G.H2.05
Ionic ICL2 R 139 - G.H5 D 368 G.H5.13
Polar ICL2 R 139 - G.H5 D 368 G.H5.13
Hydrophobic ICL2 R 139 - G.H5 D 368 G.H5.13
Van-der-waals ICL2 R 139 - G.H5 D 368 G.H5.13
Polar TM2 S 67 2x37 G.H5 I 378 G.H5.23
Van-der-waals TM2 S 67 2x37 G.H5 I 378 G.H5.23
Ionic H8 K 330 8x49 G.H5 D 377 G.H5.22
Polar H8 K 330 8x49 G.H5 D 377 G.H5.22
Hydrophobic H8 K 330 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 K 330 8x49 G.H5 D 377 G.H5.22
Hydrophobic ICL1 M 65 12x50 G.H5 Q 381 G.H5.26
Van-der-waals ICL1 M 65 12x50 G.H5 Q 381 G.H5.26
Polar ICL1 P 63 12x48 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 P 63 12x48 G.hns1 R 55 G.hns1.02
Polar ICL3 Q 254 - G.H5 A 365 G.H5.10
Hydrophobic ICL3 Q 254 - G.H5 A 365 G.H5.10
Van-der-waals ICL3 Q 254 - G.H5 A 365 G.H5.10
Polar TM6 D 258 6x26 G.H5 T 369 G.H5.14
Hydrophobic TM6 D 258 6x26 G.H5 T 369 G.H5.14
Van-der-waals TM6 D 258 6x26 G.H5 T 369 G.H5.14
Polar ICL3 Q 253 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 Q 253 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 Q 253 - G.S6 H 348 G.S6.03
Hydrophobic TM3 R 132 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 R 132 3x50 G.H5 M 379 G.H5.24
Hydrophobic ICL3 L 238 - G.H4 L 324 G.H4.04
Hydrophobic TM6 K 264 6x32 G.H5 K 376 G.H5.21
Van-der-waals TM6 K 264 6x32 G.H5 K 376 G.H5.21
Hydrophobic TM6 A 265 6x33 G.H5 K 376 G.H5.21
Van-der-waals TM6 A 265 6x33 G.H5 K 376 G.H5.21
Hydrophobic TM6 V 257 6x25 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 V 257 6x25 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 Q 254 - G.H5 V 366 G.H5.11
Van-der-waals ICL3 Q 254 - G.H5 V 366 G.H5.11
Hydrophobic ICL3 Q 254 - G.S6 F 347 G.S6.02
Hydrophobic TM6 F 261 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 F 261 6x29 G.H5 Q 372 G.H5.17
Polar ICL2 L 143 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 143 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 143 - G.hns1 R 56 G.hns1.03
Hydrophobic TM6 V 257 6x25 G.S6 F 347 G.S6.02
Van-der-waals TM6 V 257 6x25 G.S6 F 347 G.S6.02
Polar ICL1 A 64 12x49 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 A 64 12x49 G.hns1 R 55 G.hns1.02
Hydrophobic H8 K 330 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 330 8x49 G.H5 Q 381 G.H5.26
Polar H8 K 329 8x48 G.h3s5 N 288 G.h3s5.02
Polar ICL1 R 66 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 R 66 12x51 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 R 66 12x51 G.hns1 R 55 G.hns1.02
Hydrophobic H8 I 328 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM2 S 67 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 S 67 2x37 G.hns1 R 55 G.hns1.02
Polar TM4 N 144 4x38 G.HN R 52 G.HN.52
Hydrophobic TM4 N 144 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 N 144 4x38 G.HN R 52 G.HN.52
Hydrophobic ICL3 Q 253 - G.S6 F 347 G.S6.02
Hydrophobic H8 F 331 8x50 G.H5 Q 381 G.H5.26
Van-der-waals H8 F 331 8x50 G.H5 Q 381 G.H5.26
Hydrophobic TM2 I 69 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 I 69 2x39 G.H5 I 378 G.H5.23
Polar TM6 S 260 6x28 G.H5 K 376 G.H5.21
Hydrophobic TM4 N 144 4x38 G.hns1 R 56 G.hns1.03
Polar C-term R 355 - G.H3 K 284 G.H3.16
Hydrophobic C-term R 355 - G.H3 K 284 G.H3.16
Van-der-waals C-term R 355 - G.H3 K 284 G.H3.16
Hydrophobic TM6 A 265 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 265 6x33 G.H5 M 379 G.H5.24
Hydrophobic C-term I 357 - G.H2 F 239 G.H2.08
Polar ICL3 Q 250 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 Q 250 - G.S6 H 349 G.S6.04
Van-der-waals ICL3 Q 250 - G.S6 H 349 G.S6.04
Hydrophobic TM3 I 135 3x53 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 135 3x53 G.H5 L 375 G.H5.20
Polar ICL3 Q 250 - G.S6 F 350 G.S6.05
Hydrophobic ICL3 Q 250 - G.S6 F 350 G.S6.05
Van-der-waals ICL3 Q 250 - G.S6 F 350 G.S6.05
Polar ICL3 Q 254 - G.H5 T 369 G.H5.14
Polar ICL2 R 139 - G.H5 H 364 G.H5.09
Hydrophobic ICL2 R 139 - G.H5 H 364 G.H5.09
Hydrophobic C-term I 353 - G.H3 K 284 G.H3.16
Van-der-waals C-term I 353 - G.H3 K 284 G.H3.16
Hydrophobic TM2 L 73 2x43 G.H5 L 380 G.H5.25
Hydrophobic H8 I 328 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 I 328 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL3 L 238 - G.HG M 298 G.HG.01
Hydrophobic TM6 T 268 6x36 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 268 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 I 269 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 269 6x37 G.H5 M 379 G.H5.24