GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | V | 257 | 6x25 | G.h4s6 | T | 316 | G.h4s6.10 |
Van-der-waals | TM6 | V | 257 | 6x25 | G.h4s6 | T | 316 | G.h4s6.10 |
Hydrophobic | TM6 | F | 266 | 6x34 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 264 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 264 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL3 | L | 236 | - | G.H4 | E | 297 | G.H4.04 |
Polar | ICL2 | D | 141 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | D | 141 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | D | 141 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM6 | V | 257 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | V | 257 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | I | 269 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | R | 355 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | C-term | R | 355 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | C-term | R | 355 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Ionic | ICL2 | D | 141 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | D | 141 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | D | 141 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | D | 141 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | TM2 | N | 70 | 2x40 | G.H5 | G | 352 | G.H5.24 |
Polar | TM6 | D | 258 | 6x26 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM6 | D | 258 | 6x26 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM6 | D | 258 | 6x26 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | H8 | I | 328 | 8x47 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | I | 328 | 8x47 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM3 | I | 136 | 3x54 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | TM3 | I | 136 | 3x54 | G.H5 | K | 349 | G.H5.21 |
Polar | TM4 | P | 145 | 4x39 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | P | 145 | 4x39 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | P | 145 | 4x39 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM6 | L | 272 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 272 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Polar | TM5 | V | 222 | 5x65 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM5 | V | 222 | 5x65 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM5 | V | 222 | 5x65 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM2 | I | 69 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | I | 69 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM2 | S | 67 | 2x37 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM2 | S | 67 | 2x37 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | H8 | I | 328 | 8x47 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | H8 | I | 328 | 8x47 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | R | 132 | 3x50 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | R | 132 | 3x50 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | K | 142 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | K | 142 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | K | 142 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM3 | I | 128 | 3x46 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | I | 128 | 3x46 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM4 | K | 149 | 4x43 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | K | 149 | 4x43 | G.HN | R | 24 | G.HN.48 |
Polar | TM4 | R | 146 | 4x40 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 146 | 4x40 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 146 | 4x40 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM6 | I | 269 | 6x37 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | I | 269 | 6x37 | G.H5 | F | 354 | G.H5.26 |
Polar | C-term | R | 355 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | R | 355 | - | G.S1 | K | 35 | G.S1.03 |
Van-der-waals | C-term | R | 355 | - | G.S1 | K | 35 | G.S1.03 |
Polar | C-term | Y | 363 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | Y | 363 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | Y | 363 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | TM6 | F | 261 | 6x29 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM6 | F | 261 | 6x29 | G.H5 | D | 350 | G.H5.22 |
Ionic | H8 | K | 329 | 8x48 | G.h3s5 | D | 261 | G.h3s5.02 |
Polar | H8 | K | 329 | 8x48 | G.h3s5 | D | 261 | G.h3s5.02 |
Hydrophobic | H8 | K | 329 | 8x48 | G.h3s5 | D | 261 | G.h3s5.02 |
Van-der-waals | H8 | K | 329 | 8x48 | G.h3s5 | D | 261 | G.h3s5.02 |
Polar | H8 | K | 330 | 8x49 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | H8 | K | 330 | 8x49 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | T | 267 | 6x35 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM2 | L | 73 | 2x43 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM2 | L | 73 | 2x43 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | R | 132 | 3x50 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | TM3 | R | 132 | 3x50 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | TM3 | R | 132 | 3x50 | G.H5 | K | 349 | G.H5.21 |
Polar | TM6 | K | 262 | 6x30 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | C-term | Y | 363 | - | G.hfs2 | G | 183 | G.hfs2.07 |
Van-der-waals | C-term | Y | 363 | - | G.hfs2 | G | 183 | G.hfs2.07 |
Hydrophobic | ICL1 | P | 63 | 12x48 | G.HN | L | 23 | G.HN.47 |
Van-der-waals | ICL1 | P | 63 | 12x48 | G.HN | L | 23 | G.HN.47 |
Polar | ICL2 | L | 143 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | L | 143 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | L | 143 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL3 | Q | 253 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | ICL3 | Q | 253 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | ICL3 | Q | 253 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM4 | N | 144 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | N | 144 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM3 | I | 135 | 3x53 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | I | 135 | 3x53 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM4 | R | 146 | 4x40 | G.HN | R | 21 | G.HN.45 |
Hydrophobic | TM6 | K | 262 | 6x30 | G.H5 | V | 342 | G.H5.14 |
Van-der-waals | C-term | I | 353 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Ionic | ICL1 | R | 66 | 12x51 | G.HN | D | 20 | G.HN.44 |
Polar | ICL1 | R | 66 | 12x51 | G.HN | D | 20 | G.HN.44 |
Van-der-waals | ICL1 | R | 66 | 12x51 | G.HN | D | 20 | G.HN.44 |
Hydrophobic | TM6 | V | 257 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | V | 257 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM6 | A | 265 | 6x33 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | TM6 | A | 265 | 6x33 | G.H5 | K | 349 | G.H5.21 |
Ionic | TM4 | R | 146 | 4x40 | G.HN | E | 25 | G.HN.49 |
Polar | TM4 | R | 146 | 4x40 | G.HN | E | 25 | G.HN.49 |
Van-der-waals | TM4 | R | 146 | 4x40 | G.HN | E | 25 | G.HN.49 |
Hydrophobic | ICL3 | L | 238 | - | G.H4 | A | 301 | G.H4.08 |
Van-der-waals | ICL3 | L | 238 | - | G.H4 | A | 301 | G.H4.08 |
Hydrophobic | TM6 | V | 257 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | V | 257 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM6 | F | 261 | 6x29 | G.H5 | N | 346 | G.H5.18 |
Van-der-waals | TM6 | F | 261 | 6x29 | G.H5 | N | 346 | G.H5.18 |
Van-der-waals | ICL2 | Q | 140 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM6 | K | 262 | 6x30 | G.H5 | N | 346 | G.H5.18 |
Van-der-waals | TM6 | K | 262 | 6x30 | G.H5 | N | 346 | G.H5.18 |
Ionic | ICL2 | R | 139 | - | G.H5 | D | 337 | G.H5.09 |
Polar | ICL2 | R | 139 | - | G.H5 | D | 337 | G.H5.09 |
Ionic | TM6 | D | 258 | 6x26 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | A | 265 | 6x33 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | A | 265 | 6x33 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM4 | N | 144 | 4x38 | G.hns1 | R | 32 | G.hns1.03 |
Polar | C-term | R | 355 | - | G.H2 | C | 214 | G.H2.10 |
Hydrophobic | C-term | R | 355 | - | G.H2 | C | 214 | G.H2.10 |
Van-der-waals | C-term | R | 355 | - | G.H2 | C | 214 | G.H2.10 |
Hydrophobic | TM6 | V | 257 | 6x25 | G.h4s6 | K | 317 | G.h4s6.11 |
Van-der-waals | TM2 | L | 71 | 2x41 | G.HN | R | 24 | G.HN.48 |
Polar | TM2 | S | 67 | 2x37 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | S | 67 | 2x37 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | I | 69 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Ionic | C-term | R | 355 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Polar | C-term | R | 355 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | C-term | R | 355 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | R | 355 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | C-term | I | 353 | - | G.H3 | W | 258 | G.H3.17 |
Van-der-waals | C-term | I | 353 | - | G.H3 | W | 258 | G.H3.17 |
Hydrophobic | TM6 | K | 262 | 6x30 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | K | 262 | 6x30 | G.H5 | K | 345 | G.H5.17 |
Polar | TM2 | N | 70 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | N | 70 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | R | 139 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 139 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | TM7 | Y | 324 | 7x53 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM7 | Y | 324 | 7x53 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | L | 73 | 2x43 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | L | 73 | 2x43 | G.H5 | G | 352 | G.H5.24 |
Polar | TM6 | D | 258 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | D | 258 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | D | 258 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | T | 268 | 6x36 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | T | 268 | 6x36 | G.H5 | F | 354 | G.H5.26 |
Ionic | ICL2 | R | 139 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL2 | R | 139 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | R | 139 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL2 | R | 139 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | D | 141 | - | G.S3 | L | 194 | G.S3.01 |