GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM2 | I | 69 | 2x39 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM2 | I | 69 | 2x39 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL3 | L | 238 | - | G.H4 | D | 330 | G.H4.13 |
Van-der-waals | ICL3 | L | 238 | - | G.H4 | D | 330 | G.H4.13 |
Polar | C-term | R | 355 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Hydrophobic | C-term | R | 355 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Van-der-waals | C-term | R | 355 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Hydrophobic | TM1 | V | 59 | 1x57 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | D | 141 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL2 | D | 141 | - | G.H5 | L | 375 | G.H5.20 |
Polar | ICL3 | L | 238 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL3 | L | 238 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | L | 238 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL3 | L | 238 | - | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | ICL3 | L | 238 | - | G.H4 | R | 329 | G.H4.12 |
Polar | TM6 | S | 260 | 6x28 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM6 | S | 260 | 6x28 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM6 | S | 260 | 6x28 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | ICL3 | Q | 250 | - | G.H4 | L | 333 | G.H4.16 |
Polar | ICL3 | Q | 253 | - | G.h4s6 | S | 336 | G.h4s6.02 |
Ionic | TM6 | D | 258 | 6x26 | G.H5 | R | 372 | G.H5.17 |
Polar | TM6 | D | 258 | 6x26 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM6 | D | 258 | 6x26 | G.H5 | R | 372 | G.H5.17 |
Polar | ICL3 | Q | 240 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL3 | Q | 240 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | Q | 240 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | TM6 | S | 256 | 6x24 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM6 | S | 256 | 6x24 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | C-term | R | 356 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Hydrophobic | C-term | I | 357 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Van-der-waals | C-term | I | 357 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Hydrophobic | ICL1 | P | 63 | 12x48 | G.HN | L | 37 | G.HN.52 |
Hydrophobic | ICL3 | Q | 253 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Van-der-waals | ICL3 | Q | 253 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Polar | C-term | C | 365 | - | G.S2 | I | 194 | G.S2.01 |
Hydrophobic | C-term | C | 365 | - | G.S2 | I | 194 | G.S2.01 |
Van-der-waals | C-term | C | 365 | - | G.S2 | I | 194 | G.S2.01 |
Hydrophobic | TM2 | I | 69 | 2x39 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM2 | I | 69 | 2x39 | G.H5 | E | 379 | G.H5.24 |
Polar | ICL3 | D | 237 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Hydrophobic | TM2 | L | 73 | 2x43 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM2 | L | 73 | 2x43 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | C-term | I | 353 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Polar | C-term | P | 359 | - | G.S2 | R | 198 | G.S2.05 |
Hydrophobic | TM6 | F | 261 | 6x29 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | TM6 | F | 261 | 6x29 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | C-term | P | 359 | - | G.hns1 | Y | 39 | G.hns1.01 |
Van-der-waals | C-term | P | 359 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | ICL1 | P | 63 | 12x48 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL1 | P | 63 | 12x48 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | C-term | I | 357 | - | G.S1 | R | 44 | G.S1.03 |
Van-der-waals | C-term | I | 357 | - | G.S1 | R | 44 | G.S1.03 |
Hydrophobic | ICL3 | L | 238 | - | G.H4 | L | 333 | G.H4.16 |
Van-der-waals | ICL3 | L | 238 | - | G.H4 | L | 333 | G.H4.16 |
Polar | TM3 | R | 132 | 3x50 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM3 | R | 132 | 3x50 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM3 | R | 132 | 3x50 | G.H5 | L | 381 | G.H5.26 |
Polar | H8 | K | 330 | 8x49 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | H8 | K | 330 | 8x49 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | H8 | K | 330 | 8x49 | G.H5 | Q | 377 | G.H5.22 |
Polar | ICL3 | R | 239 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL3 | R | 239 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | ICL3 | R | 239 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL1 | P | 63 | 12x48 | G.HN | R | 36 | G.HN.51 |
Van-der-waals | ICL1 | P | 63 | 12x48 | G.HN | R | 36 | G.HN.51 |
Hydrophobic | TM6 | I | 269 | 6x37 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | I | 269 | 6x37 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | C-term | I | 353 | - | G.H3 | W | 268 | G.H3.17 |
Van-der-waals | C-term | I | 353 | - | G.H3 | W | 268 | G.H3.17 |
Polar | C-term | R | 355 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Hydrophobic | C-term | R | 355 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Van-der-waals | C-term | R | 355 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Polar | C-term | I | 357 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | C-term | I | 357 | - | G.hns1 | Y | 39 | G.hns1.01 |
Van-der-waals | C-term | I | 357 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | H8 | K | 330 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | V | 372 | - | H.HA | K | 84 | H.HA.13 |
Van-der-waals | C-term | V | 372 | - | H.HA | K | 84 | H.HA.13 |
Ionic | TM3 | R | 132 | 3x50 | G.H5 | E | 379 | G.H5.24 |
Polar | TM3 | R | 132 | 3x50 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | R | 132 | 3x50 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM3 | R | 132 | 3x50 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | L | 272 | 6x40 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | C-term | C | 365 | - | G.S2 | F | 195 | G.S2.02 |
Polar | ICL3 | D | 237 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL3 | D | 237 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | D | 237 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL1 | A | 64 | 12x49 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL1 | A | 64 | 12x49 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | TM1 | R | 62 | 1x60 | G.HN | R | 36 | G.HN.51 |
Van-der-waals | TM1 | R | 62 | 1x60 | G.HN | R | 36 | G.HN.51 |
Polar | TM6 | V | 257 | 6x25 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM6 | V | 257 | 6x25 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM6 | V | 257 | 6x25 | G.h4s6 | Y | 345 | G.h4s6.20 |
Polar | TM1 | Q | 61 | 1x59 | G.HN | R | 36 | G.HN.51 |
Van-der-waals | TM1 | Q | 61 | 1x59 | G.HN | R | 36 | G.HN.51 |
Hydrophobic | ICL3 | Q | 254 | - | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | ICL3 | Q | 254 | - | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | C-term | Q | 369 | - | G.hfs2 | V | 189 | G.hfs2.03 |
Hydrophobic | ICL1 | M | 65 | 12x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | V | 257 | 6x25 | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | TM6 | V | 257 | 6x25 | G.S6 | Y | 347 | G.S6.02 |
Polar | TM2 | N | 70 | 2x40 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | N | 70 | 2x40 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | H8 | I | 328 | 8x47 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | C-term | C | 365 | - | G.hfs2 | G | 193 | G.hfs2.07 |
Van-der-waals | C-term | C | 365 | - | G.hfs2 | G | 193 | G.hfs2.07 |
Polar | C-term | Y | 363 | - | G.S2 | E | 196 | G.S2.03 |
Polar | ICL3 | Q | 250 | - | G.S6 | P | 348 | G.S6.03 |
Hydrophobic | ICL3 | Q | 250 | - | G.S6 | P | 348 | G.S6.03 |
Van-der-waals | ICL3 | Q | 250 | - | G.S6 | P | 348 | G.S6.03 |
Polar | ICL3 | Q | 250 | - | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | ICL3 | Q | 250 | - | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | TM6 | T | 268 | 6x36 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | T | 268 | 6x36 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL3 | R | 239 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Polar | ICL3 | D | 237 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Hydrophobic | ICL3 | D | 237 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Van-der-waals | ICL3 | D | 237 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Hydrophobic | C-term | I | 357 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | C-term | I | 357 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Polar | C-term | R | 355 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | C-term | R | 355 | - | G.H3 | W | 268 | G.H3.17 |
Van-der-waals | C-term | R | 355 | - | G.H3 | W | 268 | G.H3.17 |
Polar | TM2 | N | 70 | 2x40 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM2 | N | 70 | 2x40 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | N | 70 | 2x40 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | L | 238 | - | G.hgh4 | P | 308 | G.hgh4.11 |
Van-der-waals | ICL3 | L | 238 | - | G.hgh4 | P | 308 | G.hgh4.11 |
Hydrophobic | ICL3 | L | 249 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | TM6 | A | 265 | 6x33 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | A | 265 | 6x33 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL3 | D | 237 | - | G.hgh4 | P | 308 | G.hgh4.11 |
Van-der-waals | ICL3 | D | 237 | - | G.hgh4 | P | 308 | G.hgh4.11 |
Hydrophobic | ICL1 | A | 64 | 12x49 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | ICL1 | A | 64 | 12x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | H8 | F | 331 | 8x50 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL3 | R | 239 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL3 | R | 239 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | R | 239 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | TM1 | R | 62 | 1x60 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | TM1 | R | 62 | 1x60 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | TM1 | R | 62 | 1x60 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | TM2 | L | 73 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | L | 73 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL1 | M | 65 | 12x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM7 | Y | 324 | 7x53 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL1 | P | 63 | 12x48 | G.HN | Q | 33 | G.HN.48 |
Hydrophobic | H8 | I | 328 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | I | 328 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | A | 371 | - | H.HA | K | 84 | H.HA.13 |
Hydrophobic | TM2 | N | 70 | 2x40 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | C-term | R | 355 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | C-term | R | 355 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | C-term | Y | 363 | - | G.H2 | Q | 223 | G.H2.09 |
Van-der-waals | C-term | Y | 363 | - | G.H2 | Q | 223 | G.H2.09 |
Polar | TM6 | S | 260 | 6x28 | G.h4s6 | G | 342 | G.h4s6.11 |