GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | I | 222 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Polar | TM2 | N | 50 | 2x37 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | TM2 | N | 50 | 2x37 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | TM2 | N | 50 | 2x37 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | TM6 | I | 222 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | I | 222 | 6x33 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL3 | S | 211 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL3 | S | 211 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | S | 211 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM7 | Y | 286 | 7x53 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | V | 119 | 3x54 | G.H5 | H | 374 | G.H5.19 |
Ionic | TM6 | E | 218 | 6x29 | G.H5 | R | 372 | G.H5.17 |
Polar | TM6 | E | 218 | 6x29 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM6 | E | 218 | 6x29 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM6 | E | 218 | 6x29 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | ICL1 | R | 49 | - | G.HN | R | 36 | G.HN.51 |
Van-der-waals | ICL1 | R | 49 | - | G.HN | R | 36 | G.HN.51 |
Hydrophobic | TM3 | A | 118 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | A | 118 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Ionic | ICL2 | R | 124 | 34x52 | G.s2s3 | D | 202 | G.s2s3.01 |
Polar | ICL2 | R | 124 | 34x52 | G.s2s3 | D | 202 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 124 | 34x52 | G.s2s3 | D | 202 | G.s2s3.01 |
Polar | ICL2 | R | 129 | 34x57 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | R | 129 | 34x57 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | ICL2 | R | 129 | 34x57 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM4 | R | 130 | 4x38 | G.HN | L | 37 | G.HN.52 |
Hydrophobic | TM4 | R | 130 | 4x38 | G.HN | L | 37 | G.HN.52 |
Van-der-waals | TM4 | R | 130 | 4x38 | G.HN | L | 37 | G.HN.52 |
Polar | TM3 | A | 118 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | A | 118 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 118 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | L | 123 | 34x51 | G.H5 | C | 366 | G.H5.11 |
Hydrophobic | ICL2 | L | 123 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 123 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | TM3 | R | 115 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | P | 122 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Polar | TM3 | R | 115 | 3x50 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM3 | R | 115 | 3x50 | G.H5 | E | 379 | G.H5.24 |
Polar | TM1 | Q | 45 | 1x60 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM1 | Q | 45 | 1x60 | G.H5 | E | 379 | G.H5.24 |
Polar | TM2 | E | 51 | 2x38 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | E | 51 | 2x38 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | L | 123 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 123 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 122 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM5 | I | 204 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | E | 218 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | E | 218 | 6x29 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | L | 123 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | L | 123 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | TM3 | D | 114 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | D | 114 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL3 | T | 214 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL3 | S | 213 | - | G.h4s6 | Y | 345 | G.h4s6.20 |
Polar | TM4 | K | 132 | 4x40 | G.HN | Q | 33 | G.HN.48 |
Hydrophobic | TM4 | K | 132 | 4x40 | G.HN | Q | 33 | G.HN.48 |
Van-der-waals | TM4 | K | 132 | 4x40 | G.HN | Q | 33 | G.HN.48 |
Polar | ICL3 | V | 212 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL3 | V | 212 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | V | 212 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | L | 225 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL3 | S | 213 | - | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | ICL3 | S | 213 | - | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | ICL3 | S | 213 | - | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | TM6 | I | 222 | 6x33 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | I | 222 | 6x33 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | R | 124 | 34x52 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | TM6 | L | 225 | 6x36 | G.H5 | E | 379 | G.H5.24 |
Polar | ICL2 | R | 129 | 34x57 | G.H5 | H | 374 | G.H5.19 |
Aromatic | ICL2 | R | 129 | 34x57 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | R | 129 | 34x57 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | R | 129 | 34x57 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL3 | T | 214 | - | G.H5 | L | 381 | G.H5.26 |
Polar | TM3 | V | 119 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | V | 119 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | V | 119 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL2 | L | 123 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | L | 123 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Polar | ICL3 | S | 211 | - | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL3 | S | 211 | - | G.H5 | Q | 371 | G.H5.16 |
Polar | TM7 | N | 290 | 7x57 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM7 | N | 290 | 7x57 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM7 | N | 290 | 7x57 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | A | 293 | 8x50 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | A | 293 | 8x50 | G.H5 | E | 379 | G.H5.24 |
Polar | TM5 | A | 207 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM5 | A | 207 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | V | 119 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | V | 119 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | TM7 | N | 290 | 7x57 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM2 | L | 52 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | L | 52 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM3 | R | 115 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 115 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 115 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Polar | ICL3 | S | 213 | - | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | ICL3 | S | 213 | - | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | ICL3 | S | 213 | - | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | V | 208 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | L | 123 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM6 | K | 221 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 221 | 6x32 | G.H5 | L | 381 | G.H5.26 |
Polar | ICL3 | S | 213 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL3 | S | 213 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | S | 213 | - | G.H5 | D | 368 | G.H5.13 |