G12 - GPR52 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 142 3x53 G.H5 I 378 G.H5.23
Polar TM5 R 241 5x77 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM5 R 241 5x77 G.h4s6 S 343 G.h4s6.12
Polar ICL2 Q 151 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Q 151 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Q 151 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Q 151 34x55 G.S3 P 222 G.S3.02
Van-der-waals ICL2 Q 151 34x55 G.S3 P 222 G.S3.02
Polar H8 N 321 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 321 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 321 8x47 G.H5 L 380 G.H5.25
Polar H8 S 322 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 S 322 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM5 H 233 5x69 G.H5 L 371 G.H5.16
Hydrophobic TM6 D 260 6x30 G.H5 L 375 G.H5.20
Hydrophobic H8 V 323 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM3 I 143 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 375 G.H5.20
Polar TM1 H 66 1x58 G.HN C 11 G.HN.11
Hydrophobic TM1 H 66 1x58 G.HN C 11 G.HN.11
Hydrophobic TM6 Y 263 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 Y 263 6x33 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 146 34x50 G.H5 L 371 G.H5.16
Polar TM2 Y 74 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 Y 74 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 Y 74 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM5 R 241 5x77 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 P 146 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 146 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 R 262 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 262 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM5 C 230 5x66 G.H5 L 375 G.H5.20
Van-der-waals TM5 C 230 5x66 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 147 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 147 34x51 G.S1 V 58 G.S1.02
Polar TM1 C 67 1x59 G.HN C 11 G.HN.11
Hydrophobic TM1 C 67 1x59 G.HN C 11 G.HN.11
Van-der-waals TM1 C 67 1x59 G.HN C 11 G.HN.11
Polar TM3 A 142 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 142 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 142 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 I 143 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 143 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 147 34x51 G.S3 F 223 G.S3.03
Hydrophobic H8 R 330 8x56 G.HN L 8 G.HN.08
Hydrophobic ICL2 L 147 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 147 34x51 G.H5 F 363 G.H5.08
Polar ICL2 N 150 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 N 150 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 N 150 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 146 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 146 34x50 G.H5 I 370 G.H5.15
Hydrophobic H8 T 334 8x60 G.HN L 12 G.HN.12
Van-der-waals H8 T 334 8x60 G.HN L 12 G.HN.12
Hydrophobic TM2 I 80 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 147 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 147 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL3 S 246 - G.H4 D 336 G.H4.16
Hydrophobic ICL1 P 69 12x48 G.HN T 7 G.HN.07
Van-der-waals ICL1 P 69 12x48 G.HN T 7 G.HN.07
Polar TM6 Y 263 6x33 G.H5 Q 381 G.H5.26
Hydrophobic TM6 Y 263 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 Y 263 6x33 G.H5 Q 381 G.H5.26
Hydrophobic TM6 V 266 6x36 G.H5 M 379 G.H5.24
Polar TM3 R 139 3x50 G.H5 D 377 G.H5.22
Hydrophobic TM5 I 237 5x73 G.h4s6 P 345 G.h4s6.20
Ionic ICL3 E 248 - G.h4s6 R 342 G.h4s6.11
Polar ICL3 E 248 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 E 248 - G.h4s6 R 342 G.h4s6.11
Hydrophobic TM6 Y 263 6x33 G.H5 K 376 G.H5.21
Van-der-waals TM6 Y 263 6x33 G.H5 K 376 G.H5.21
Hydrophobic ICL2 L 147 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM5 R 240 5x76 G.S6 F 347 G.S6.02
Van-der-waals TM5 R 240 5x76 G.S6 F 347 G.S6.02
Hydrophobic TM3 R 139 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM6 L 267 6x37 G.H5 I 378 G.H5.23
Van-der-waals TM6 L 267 6x37 G.H5 I 378 G.H5.23
Polar ICL2 N 150 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 N 150 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 N 150 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 L 147 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 147 34x51 G.S3 I 221 G.S3.01
Polar TM5 H 233 5x69 G.H5 D 368 G.H5.13
Hydrophobic TM4 T 154 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 154 4x38 G.hns1 R 56 G.hns1.03
Aromatic TM5 F 244 5x80 G.S6 H 348 G.S6.03
Hydrophobic TM5 F 244 5x80 G.S6 H 348 G.S6.03
Van-der-waals TM5 F 244 5x80 G.S6 H 348 G.S6.03
Hydrophobic H8 S 322 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 322 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 147 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM1 C 67 1x59 G.HN L 8 G.HN.08
Polar ICL1 H 73 12x52 G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 H 73 12x52 G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 H 73 12x52 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 146 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 146 34x50 G.H5 N 374 G.H5.19
Hydrophobic TM6 Y 263 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 Y 263 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM5 F 244 5x80 G.H4 V 332 G.H4.12
Polar ICL2 Q 151 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM7 Y 317 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 143 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 143 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM5 I 229 5x65 G.H5 L 371 G.H5.16
Polar TM5 H 233 5x69 G.H5 Q 372 G.H5.17
Hydrophobic TM5 H 233 5x69 G.H5 Q 372 G.H5.17
Van-der-waals TM5 H 233 5x69 G.H5 Q 372 G.H5.17
Hydrophobic H8 R 330 8x56 G.HN V 4 G.HN.04
Van-der-waals H8 R 330 8x56 G.HN V 4 G.HN.04
Ionic TM5 R 240 5x76 G.H5 D 368 G.H5.13
Polar TM5 R 240 5x76 G.H5 D 368 G.H5.13
Hydrophobic TM5 I 237 5x73 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 237 5x73 G.H5 Q 372 G.H5.17