GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | A | 264 | 6x34 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM6 | A | 264 | 6x34 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM6 | A | 264 | 6x34 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM3 | Y | 140 | 3x51 | G.H5 | L | 349 | G.H5.25 |
Aromatic | TM5 | F | 244 | 5x80 | G.H5 | F | 330 | G.H5.06 |
Hydrophobic | TM5 | F | 244 | 5x80 | G.H5 | F | 330 | G.H5.06 |
Van-der-waals | TM5 | F | 244 | 5x80 | G.H5 | F | 330 | G.H5.06 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | L | 147 | 34x51 | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | TM3 | A | 142 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | A | 142 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Ionic | TM5 | R | 240 | 5x76 | G.H5 | D | 337 | G.H5.13 |
Polar | TM5 | R | 240 | 5x76 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM5 | R | 240 | 5x76 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM5 | C | 230 | 5x66 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM5 | C | 230 | 5x66 | G.H5 | F | 350 | G.H5.26 |
Polar | ICL2 | Q | 151 | 34x55 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 151 | 34x55 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 151 | 34x55 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | TM6 | Y | 263 | 6x33 | G.H5 | F | 350 | G.H5.26 |
Polar | TM6 | A | 264 | 6x34 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | A | 264 | 6x34 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | A | 264 | 6x34 | G.H5 | F | 350 | G.H5.26 |
Polar | ICL2 | L | 147 | 34x51 | G.S1 | T | 29 | G.S1.01 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.S1 | T | 29 | G.S1.01 |
Van-der-waals | ICL2 | L | 147 | 34x51 | G.S1 | T | 29 | G.S1.01 |
Hydrophobic | TM6 | S | 258 | 6x28 | G.H5 | K | 345 | G.H5.21 |
Van-der-waals | TM6 | S | 258 | 6x28 | G.H5 | K | 345 | G.H5.21 |
Ionic | TM6 | D | 260 | 6x30 | G.H5 | K | 345 | G.H5.21 |
Polar | TM6 | D | 260 | 6x30 | G.H5 | K | 345 | G.H5.21 |
Hydrophobic | TM6 | D | 260 | 6x30 | G.H5 | K | 345 | G.H5.21 |
Van-der-waals | TM6 | D | 260 | 6x30 | G.H5 | K | 345 | G.H5.21 |
Hydrophobic | TM5 | I | 226 | 5x62 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM5 | I | 226 | 5x62 | G.H5 | L | 349 | G.H5.25 |
Polar | TM2 | Y | 74 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM2 | Y | 74 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM2 | Y | 74 | 2x37 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.S1 | V | 30 | G.S1.02 |
Van-der-waals | ICL2 | L | 147 | 34x51 | G.S1 | V | 30 | G.S1.02 |
Hydrophobic | TM6 | D | 260 | 6x30 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | D | 260 | 6x30 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.h2s4 | T | 215 | G.h2s4.05 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | I | 143 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Ionic | TM5 | R | 240 | 5x76 | G.H5 | D | 333 | G.H5.09 |
Polar | TM5 | R | 240 | 5x76 | G.H5 | D | 333 | G.H5.09 |
Hydrophobic | TM5 | R | 240 | 5x76 | G.H5 | D | 333 | G.H5.09 |
Van-der-waals | TM5 | R | 240 | 5x76 | G.H5 | D | 333 | G.H5.09 |
Van-der-waals | TM5 | R | 240 | 5x76 | G.H5 | A | 334 | G.H5.10 |
Polar | TM3 | R | 139 | 3x50 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM3 | R | 139 | 3x50 | G.H5 | D | 346 | G.H5.22 |
Polar | ICL2 | S | 148 | 34x52 | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | ICL2 | S | 148 | 34x52 | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | S | 148 | 34x52 | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | ICL2 | L | 152 | 34x56 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | L | 152 | 34x56 | G.hns1 | A | 27 | G.hns1.02 |
Ionic | ICL3 | E | 248 | - | G.H4 | K | 300 | G.H4.12 |
Polar | TM4 | R | 157 | 4x41 | G.HN | A | 23 | G.HN.51 |
Hydrophobic | TM4 | R | 157 | 4x41 | G.HN | A | 23 | G.HN.51 |
Van-der-waals | TM4 | R | 157 | 4x41 | G.HN | A | 23 | G.HN.51 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | L | 147 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Ionic | TM5 | H | 233 | 5x69 | G.H5 | D | 337 | G.H5.13 |
Polar | TM5 | H | 233 | 5x69 | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM5 | H | 233 | 5x69 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM5 | H | 233 | 5x69 | G.H5 | D | 337 | G.H5.13 |
Polar | TM6 | R | 261 | 6x31 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | R | 261 | 6x31 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | R | 261 | 6x31 | G.H5 | F | 350 | G.H5.26 |
Polar | ICL2 | S | 148 | 34x52 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | S | 148 | 34x52 | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | S | 148 | 34x52 | G.hns1 | A | 27 | G.hns1.02 |
Polar | TM3 | R | 139 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | R | 139 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.hns1 | A | 27 | G.hns1.02 |
Ionic | TM5 | E | 236 | 5x72 | G.s2s3 | K | 188 | G.s2s3.01 |
Hydrophobic | TM6 | A | 264 | 6x34 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | A | 264 | 6x34 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM3 | K | 145 | 3x56 | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | TM5 | H | 233 | 5x69 | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | TM5 | H | 233 | 5x69 | G.H5 | I | 340 | G.H5.16 |
Aromatic | TM5 | R | 240 | 5x76 | G.H5 | F | 330 | G.H5.06 |
Hydrophobic | TM5 | R | 240 | 5x76 | G.H5 | F | 330 | G.H5.06 |
Hydrophobic | ICL2 | P | 146 | 34x50 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | P | 146 | 34x50 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | P | 146 | 34x50 | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | ICL2 | Y | 149 | 34x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | ICL2 | Y | 149 | 34x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | P | 146 | 34x50 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM3 | R | 139 | 3x50 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM5 | Y | 223 | 5x59 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM5 | Y | 223 | 5x59 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | TM6 | L | 267 | 6x37 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM6 | L | 267 | 6x37 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | ICL2 | L | 147 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | L | 147 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | TM3 | I | 143 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | I | 143 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Polar | ICL2 | Q | 151 | 34x55 | G.hns1 | D | 26 | G.hns1.01 |
Hydrophobic | ICL2 | Q | 151 | 34x55 | G.hns1 | D | 26 | G.hns1.01 |
Van-der-waals | ICL2 | Q | 151 | 34x55 | G.hns1 | D | 26 | G.hns1.01 |
Polar | ICL3 | E | 248 | - | G.H4 | N | 297 | G.H4.08 |
Hydrophobic | ICL3 | E | 248 | - | G.H4 | N | 297 | G.H4.08 |
Van-der-waals | ICL3 | E | 248 | - | G.H4 | N | 297 | G.H4.08 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | R | 139 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL2 | L | 152 | 34x56 | G.HN | E | 24 | G.HN.52 |
Hydrophobic | TM6 | Y | 263 | 6x33 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM6 | Y | 263 | 6x33 | G.H5 | G | 348 | G.H5.24 |