GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | F | 384 | - | G.H3 | T | 260 | G.H3.11 |
Van-der-waals | C-term | F | 384 | - | G.H3 | T | 260 | G.H3.11 |
Polar | H8 | R | 346 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | R | 346 | 8x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | F | 381 | - | G.H3 | L | 264 | G.H3.15 |
Van-der-waals | C-term | F | 381 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | C-term | E | 378 | - | G.H3 | W | 266 | G.H3.17 |
Polar | ICL2 | R | 149 | 34x52 | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | ICL2 | R | 149 | 34x52 | G.s2s3 | Q | 200 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 149 | 34x52 | G.s2s3 | Q | 200 | G.s2s3.01 |
Polar | ICL2 | M | 148 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | M | 148 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | C-term | I | 377 | - | G.H3 | W | 266 | G.H3.17 |
Polar | H8 | R | 346 | 8x48 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | H8 | R | 346 | 8x48 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Van-der-waals | ICL2 | M | 148 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | C-term | L | 441 | - | G.H1 | R | 63 | G.H1.09 |
Polar | TM5 | H | 242 | 5x72 | G.h4s6 | R | 337 | G.h4s6.19 |
Hydrophobic | TM5 | H | 242 | 5x72 | G.h4s6 | R | 337 | G.h4s6.19 |
Van-der-waals | TM5 | H | 242 | 5x72 | G.h4s6 | R | 337 | G.h4s6.19 |
Hydrophobic | C-term | E | 378 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | E | 378 | - | G.H2 | I | 220 | G.H2.08 |
Polar | TM5 | Q | 241 | 5x71 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | Q | 241 | 5x71 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | F | 381 | - | G.H2 | W | 219 | G.H2.07 |
Polar | TM5 | A | 238 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM5 | A | 238 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | A | 238 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | L | 385 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | L | 385 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | M | 148 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | V | 234 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | V | 234 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | L | 441 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | TM6 | K | 284 | 6x32 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | I | 377 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | I | 377 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | C-term | F | 381 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Van-der-waals | C-term | F | 381 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | P | 147 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | A | 238 | 5x68 | G.H5 | L | 368 | G.H5.20 |
Polar | TM6 | K | 284 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | K | 284 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | K | 284 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Aromatic | ICL3 | W | 248 | - | G.H4 | R | 310 | G.H4.09 |
Hydrophobic | C-term | F | 384 | - | G.H3 | A | 256 | G.H3.07 |
Hydrophobic | TM5 | V | 234 | 5x64 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.S3 | L | 204 | G.S3.03 |
Hydrophobic | C-term | L | 382 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | L | 382 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | TM6 | L | 289 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | R | 140 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | R | 140 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | F | 384 | - | G.H3 | L | 257 | G.H3.08 |
Hydrophobic | C-term | I | 377 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | H8 | N | 345 | 8x47 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | H8 | N | 345 | 8x47 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM5 | M | 231 | 5x61 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM5 | M | 231 | 5x61 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | L | 385 | - | G.H3 | L | 257 | G.H3.08 |
Hydrophobic | C-term | M | 436 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | M | 148 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | C-term | M | 436 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | M | 436 | - | G.h1ha | A | 68 | G.h1ha.02 |
Polar | ICL2 | V | 152 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | M | 148 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Polar | TM5 | H | 242 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Aromatic | TM5 | H | 242 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM5 | H | 242 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | H | 242 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | M | 436 | - | G.h1ha | G | 67 | G.h1ha.01 |
Van-der-waals | C-term | M | 436 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | C-term | F | 381 | - | G.H3 | T | 260 | G.H3.11 |
Van-der-waals | ICL2 | R | 149 | 34x52 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Aromatic | TM3 | Y | 143 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | Y | 143 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | Y | 143 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Ionic | H8 | R | 346 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | R | 346 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | H8 | R | 346 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | H8 | R | 346 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | ICL2 | V | 152 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Polar | TM5 | Q | 241 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | Q | 241 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Polar | C-term | Q | 386 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | Q | 386 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | Q | 386 | - | G.H2 | K | 217 | G.H2.05 |
Polar | TM5 | H | 242 | 5x72 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM5 | H | 242 | 5x72 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | C-term | L | 385 | - | G.H2 | K | 213 | G.H2.01 |
Ionic | C-term | D | 433 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Polar | C-term | D | 433 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | C-term | D | 433 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Polar | H8 | R | 346 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | R | 346 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | R | 346 | 8x48 | G.H5 | N | 372 | G.H5.24 |
Ionic | TM2 | K | 75 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Polar | TM2 | K | 75 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM2 | K | 75 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | K | 75 | 2x39 | G.H5 | E | 370 | G.H5.22 |
Polar | ICL2 | R | 149 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 149 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Polar | TM6 | K | 284 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | K | 284 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | K | 284 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Polar | H8 | Q | 347 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | H8 | Q | 347 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | H8 | Q | 347 | 8x49 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL3 | M | 249 | - | G.H4 | F | 311 | G.H4.10 |
Hydrophobic | TM5 | L | 245 | 5x75 | G.H4 | T | 317 | G.H4.16 |
Van-der-waals | TM5 | L | 245 | 5x75 | G.H4 | T | 317 | G.H4.16 |
Hydrophobic | TM5 | M | 231 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | V | 288 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | V | 288 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Polar | H8 | R | 349 | 8x51 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | R | 346 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | H8 | R | 346 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | L | 385 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | TM5 | A | 235 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Polar | TM7 | L | 344 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM7 | L | 344 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | L | 344 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL3 | M | 249 | - | G.H4 | D | 314 | G.H4.13 |
Van-der-waals | ICL3 | M | 249 | - | G.H4 | D | 314 | G.H4.13 |
Polar | TM6 | A | 285 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | A | 285 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | A | 285 | 6x33 | G.H5 | L | 373 | G.H5.25 |