GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | A | 238 | 5x68 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | L | 382 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | L | 382 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | TM3 | R | 140 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | G | 389 | - | G.H2 | R | 205 | G.H2.01 |
Polar | C-term | G | 416 | - | G.S2 | E | 186 | G.S2.03 |
Van-der-waals | C-term | G | 416 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | C-term | F | 381 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | TM6 | K | 284 | 6x32 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | V | 288 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | V | 288 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | M | 148 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Ionic | H8 | R | 346 | 8x48 | G.H5 | E | 346 | G.H5.18 |
Polar | H8 | R | 346 | 8x48 | G.H5 | E | 346 | G.H5.18 |
Van-der-waals | C-term | F | 381 | - | G.H3 | S | 252 | G.H3.11 |
Polar | TM5 | A | 238 | 5x68 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM5 | A | 238 | 5x68 | G.H5 | K | 345 | G.H5.17 |
Polar | TM3 | Y | 143 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | Y | 143 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | Y | 143 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | L | 385 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | C-term | L | 385 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | L | 385 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | ICL3 | M | 249 | - | G.H4 | E | 297 | G.H4.04 |
Hydrophobic | C-term | T | 388 | - | G.H3 | H | 248 | G.H3.07 |
Van-der-waals | C-term | T | 388 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | Q | 386 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | Q | 386 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | L | 245 | 5x75 | G.S6 | H | 322 | G.S6.04 |
Polar | C-term | Q | 417 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Van-der-waals | C-term | Q | 417 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Hydrophobic | C-term | V | 410 | - | H.hbhc | D | 116 | H.hbhc.04 |
Ionic | C-term | E | 406 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Polar | C-term | E | 406 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Van-der-waals | C-term | E | 406 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | C-term | V | 410 | - | H.HA | S | 75 | H.HA.13 |
Hydrophobic | TM5 | V | 234 | 5x64 | G.H5 | L | 348 | G.H5.20 |
Aromatic | C-term | F | 381 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | F | 381 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | F | 381 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | TM4 | L | 156 | 4x39 | G.HN | Q | 24 | G.HN.48 |
Polar | TM6 | K | 284 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 284 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 284 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL3 | M | 249 | - | G.S6 | M | 323 | G.S6.05 |
Van-der-waals | ICL3 | M | 249 | - | G.S6 | M | 323 | G.S6.05 |
Polar | C-term | E | 420 | - | G.hfs2 | G | 183 | G.hfs2.07 |
Hydrophobic | C-term | E | 420 | - | G.hfs2 | G | 183 | G.hfs2.07 |
Van-der-waals | C-term | E | 420 | - | G.hfs2 | G | 183 | G.hfs2.07 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 147 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Polar | C-term | I | 418 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | I | 418 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | I | 418 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | F | 412 | - | H.HA | E | 68 | H.HA.06 |
Van-der-waals | C-term | F | 412 | - | H.HA | E | 68 | H.HA.06 |
Ionic | TM2 | K | 75 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Ionic | C-term | K | 404 | - | G.s4h3 | E | 238 | G.s4h3.12 |
Polar | TM6 | A | 285 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 285 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 285 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | TM5 | H | 242 | 5x72 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM5 | H | 242 | 5x72 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM5 | H | 242 | 5x72 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM5 | L | 245 | 5x75 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM5 | L | 245 | 5x75 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | C-term | I | 377 | - | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | ICL3 | M | 249 | - | G.H4 | F | 296 | G.H4.03 |
Van-der-waals | ICL3 | M | 249 | - | G.H4 | F | 296 | G.H4.03 |
Hydrophobic | C-term | I | 414 | - | G.S2 | I | 185 | G.S2.02 |
Van-der-waals | C-term | I | 414 | - | G.S2 | I | 185 | G.S2.02 |
Polar | ICL2 | E | 151 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | E | 151 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | E | 151 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | C-term | Q | 417 | - | G.S2 | I | 185 | G.S2.02 |
Hydrophobic | C-term | E | 378 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | E | 378 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | C-term | L | 426 | - | G.H2 | H | 213 | G.H2.09 |
Van-der-waals | C-term | L | 426 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | M | 148 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Polar | H8 | N | 345 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | N | 345 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | N | 345 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | C-term | G | 416 | - | G.S2 | I | 185 | G.S2.02 |
Van-der-waals | C-term | G | 416 | - | G.S2 | I | 185 | G.S2.02 |
Polar | ICL3 | T | 251 | - | G.H4 | E | 297 | G.H4.04 |
Hydrophobic | ICL3 | T | 251 | - | G.H4 | E | 297 | G.H4.04 |
Van-der-waals | ICL3 | T | 251 | - | G.H4 | E | 297 | G.H4.04 |
Hydrophobic | TM5 | M | 231 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | L | 385 | - | G.H3 | L | 249 | G.H3.08 |
Van-der-waals | C-term | L | 385 | - | G.H3 | L | 249 | G.H3.08 |
Aromatic | C-term | F | 412 | - | H.HA | F | 69 | H.HA.07 |
Hydrophobic | C-term | F | 412 | - | H.HA | F | 69 | H.HA.07 |
Polar | C-term | E | 374 | - | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | ICL2 | E | 151 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | E | 151 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | V | 152 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | V | 152 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM6 | V | 288 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | V | 288 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | I | 377 | - | G.H3 | H | 256 | G.H3.15 |
Ionic | TM5 | H | 242 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM5 | H | 242 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | H | 242 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | H | 242 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Ionic | C-term | E | 420 | - | G.H2 | K | 210 | G.H2.06 |
Polar | C-term | E | 420 | - | G.H2 | K | 210 | G.H2.06 |
Hydrophobic | C-term | E | 420 | - | G.H2 | K | 210 | G.H2.06 |
Van-der-waals | C-term | E | 420 | - | G.H2 | K | 210 | G.H2.06 |
Polar | H8 | R | 346 | 8x48 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | R | 346 | 8x48 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM6 | G | 281 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | A | 238 | 5x68 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | F | 384 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | F | 384 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | ICL3 | T | 247 | - | G.H4 | K | 304 | G.H4.12 |
Van-der-waals | ICL3 | T | 247 | - | G.H4 | K | 304 | G.H4.12 |
Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 144 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | H8 | Q | 347 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | Q | 347 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | Q | 347 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | ICL2 | V | 152 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | V | 152 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | V | 152 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Polar | TM7 | L | 344 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Ionic | TM6 | R | 278 | 6x26 | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | C-term | F | 412 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Hydrophobic | C-term | I | 418 | - | G.S3 | F | 199 | G.S3.06 |
Ionic | ICL1 | R | 74 | 12x51 | G.HN | E | 20 | G.HN.44 |
Polar | ICL1 | R | 74 | 12x51 | G.HN | E | 20 | G.HN.44 |
Van-der-waals | ICL1 | R | 74 | 12x51 | G.HN | E | 20 | G.HN.44 |
Hydrophobic | TM5 | A | 239 | 5x69 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | I | 414 | - | G.hfs2 | T | 181 | G.hfs2.05 |
Ionic | ICL3 | R | 253 | - | G.H4 | D | 298 | G.H4.05 |
Polar | ICL3 | R | 253 | - | G.H4 | D | 298 | G.H4.05 |
Hydrophobic | TM3 | V | 144 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | V | 144 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | Q | 417 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | Q | 417 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | TM6 | K | 284 | 6x32 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | K | 284 | 6x32 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.H5 | V | 339 | G.H5.11 |
Hydrophobic | C-term | P | 407 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | P | 407 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | C-term | I | 418 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | TM5 | V | 234 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | V | 234 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | I | 414 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Hydrophobic | TM5 | A | 235 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | A | 235 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | I | 377 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | I | 377 | - | G.H3 | K | 257 | G.H3.16 |
Polar | TM3 | Y | 143 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | Y | 143 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | Y | 143 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Aromatic | TM5 | H | 242 | 5x72 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | H | 242 | 5x72 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM5 | H | 242 | 5x72 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | L | 385 | - | G.H2 | W | 211 | G.H2.07 |
Van-der-waals | C-term | L | 385 | - | G.H2 | W | 211 | G.H2.07 |
Aromatic | C-term | F | 381 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | C-term | F | 381 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | C-term | F | 381 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | ICL2 | M | 148 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | M | 148 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | C-term | F | 412 | - | H.HA | V | 72 | H.HA.10 |
Van-der-waals | C-term | F | 412 | - | H.HA | V | 72 | H.HA.10 |
Hydrophobic | H8 | R | 346 | 8x48 | G.H5 | K | 349 | G.H5.21 |