GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | P | 123 | - | G.s2s3 | N | 198 | G.s2s3.02 |
Ionic | TM6 | R | 233 | 6x27 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM5 | A | 202 | 5x68 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM5 | A | 202 | 5x68 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | L | 327 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | L | 327 | - | G.H2 | R | 214 | G.H2.05 |
Polar | TM6 | R | 233 | 6x27 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | R | 233 | 6x27 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | R | 233 | 6x27 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | A | 242 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | I | 117 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | L | 121 | - | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | L | 121 | - | G.S3 | I | 199 | G.S3.01 |
Polar | TM6 | K | 238 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | K | 238 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | K | 238 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | P | 123 | - | G.S3 | I | 199 | G.S3.01 |
Polar | ICL3 | S | 217 | - | G.s6h5 | D | 333 | G.s6h5.05 |
Polar | H8 | Q | 294 | 8x47 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | H8 | Q | 294 | 8x47 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | H8 | Q | 294 | 8x47 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | L | 121 | - | G.H5 | V | 344 | G.H5.11 |
Hydrophobic | ICL3 | I | 226 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | TM5 | A | 199 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM6 | L | 234 | 6x28 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | L | 234 | 6x28 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM3 | L | 116 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | L | 116 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | L | 227 | - | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | C-term | L | 326 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | L | 326 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | C-term | L | 330 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | ICL3 | L | 227 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | ICL3 | L | 227 | - | G.H4 | V | 314 | G.H4.16 |
Hydrophobic | ICL2 | P | 120 | - | G.H5 | K | 345 | G.H5.12 |
Polar | C-term | Q | 331 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | Q | 331 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | Q | 331 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | L | 326 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Hydrophobic | ICL2 | L | 121 | - | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | L | 121 | - | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL3 | S | 217 | - | G.S6 | F | 328 | G.S6.05 |
Van-der-waals | ICL3 | S | 217 | - | G.S6 | F | 328 | G.S6.05 |
Hydrophobic | ICL3 | I | 226 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | ICL3 | I | 226 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | TM6 | R | 233 | 6x27 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | TM6 | R | 233 | 6x27 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM2 | R | 46 | 2x38 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | L | 121 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | L | 121 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM3 | I | 117 | 3x54 | G.H5 | N | 352 | G.H5.19 |
Ionic | TM2 | R | 46 | 2x38 | G.H5 | E | 355 | G.H5.22 |
Polar | TM2 | R | 46 | 2x38 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | C-term | L | 326 | - | G.H3 | W | 263 | G.H3.17 |
Polar | TM2 | L | 45 | 2x37 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM2 | L | 45 | 2x37 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM3 | R | 113 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 113 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM7 | L | 293 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM7 | L | 293 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | L | 293 | 7x56 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL3 | S | 225 | - | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | ICL3 | S | 217 | - | G.S6 | H | 327 | G.S6.04 |
Van-der-waals | ICL3 | S | 217 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | C-term | P | 323 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | TM5 | V | 198 | 5x64 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | V | 198 | 5x64 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL3 | L | 224 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | ICL3 | L | 224 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ICL3 | P | 229 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | ICL2 | P | 120 | - | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | P | 120 | - | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM3 | I | 117 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | L | 121 | - | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | L | 121 | - | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | C-term | C | 329 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | C-term | W | 321 | - | G.H3 | P | 262 | G.H3.16 |
Van-der-waals | C-term | W | 321 | - | G.H3 | P | 262 | G.H3.16 |
Polar | TM6 | A | 239 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | A | 239 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | A | 239 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Polar | TM6 | R | 231 | 6x25 | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | TM6 | R | 231 | 6x25 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | TM6 | R | 231 | 6x25 | G.h4s6 | S | 320 | G.h4s6.11 |
Polar | C-term | L | 330 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | L | 330 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | L | 330 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | ICL3 | L | 215 | - | G.H5 | E | 335 | G.H5.02 |
Hydrophobic | C-term | L | 327 | - | G.H2 | I | 217 | G.H2.08 |
Polar | H8 | R | 295 | 8x48 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | H8 | R | 295 | 8x48 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | H8 | R | 295 | 8x48 | G.H5 | E | 355 | G.H5.22 |
Polar | TM3 | L | 116 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | L | 116 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | L | 116 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL2 | L | 121 | - | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | L | 121 | - | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM5 | A | 199 | 5x65 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | H8 | P | 296 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Polar | H8 | Q | 294 | 8x47 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | H8 | Q | 294 | 8x47 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | H8 | Q | 294 | 8x47 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | L | 330 | - | G.H2 | W | 216 | G.H2.07 |
Hydrophobic | TM5 | I | 195 | 5x61 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM5 | I | 195 | 5x61 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | K | 238 | 6x32 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | K | 238 | 6x32 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | P | 120 | - | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | C-term | L | 330 | - | G.H3 | I | 258 | G.H3.12 |
Hydrophobic | TM6 | P | 243 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | P | 243 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Polar | TM2 | R | 46 | 2x38 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM2 | R | 46 | 2x38 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM2 | R | 46 | 2x38 | G.H5 | N | 352 | G.H5.19 |
Polar | ICL3 | S | 225 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | ICL3 | S | 225 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | ICL3 | S | 225 | - | G.S6 | S | 326 | G.S6.03 |
Polar | ICL1 | G | 44 | - | G.hns1 | R | 37 | G.hns1.02 |
Aromatic | C-term | W | 321 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | W | 321 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | W | 321 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | ICL3 | L | 227 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | ICL2 | P | 123 | - | G.hns1 | R | 38 | G.hns1.03 |
Ionic | ICL3 | R | 223 | - | G.H4 | E | 307 | G.H4.09 |
Polar | ICL3 | R | 223 | - | G.H4 | E | 307 | G.H4.09 |
Van-der-waals | ICL3 | R | 223 | - | G.H4 | E | 307 | G.H4.09 |
Hydrophobic | TM3 | I | 117 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | I | 117 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Polar | TM6 | K | 238 | 6x32 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | K | 238 | 6x32 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | K | 238 | 6x32 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | L | 330 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | C-term | L | 326 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | L | 326 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | L | 326 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | TM3 | I | 117 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | I | 117 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Polar | TM2 | D | 47 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | D | 47 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | D | 47 | 2x39 | G.H5 | Y | 356 | G.H5.23 |