Gt2 - GPR62 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 L 121 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 121 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 121 - G.S3 L 194 G.S3.01
Ionic H8 R 295 8x48 G.H5 D 350 G.H5.22
Polar H8 R 295 8x48 G.H5 D 350 G.H5.22
Hydrophobic H8 R 295 8x48 G.H5 D 350 G.H5.22
Van-der-waals H8 R 295 8x48 G.H5 D 350 G.H5.22
Hydrophobic TM5 I 195 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 195 5x61 G.H5 L 353 G.H5.25
Hydrophobic C-term W 321 - G.h2s4 F 215 G.h2s4.01
Hydrophobic TM3 I 117 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 117 3x54 G.H5 L 348 G.H5.20
Polar TM5 A 202 5x68 G.H5 K 345 G.H5.17
Hydrophobic TM5 A 202 5x68 G.H5 K 345 G.H5.17
Van-der-waals TM5 A 202 5x68 G.H5 K 345 G.H5.17
Hydrophobic H8 P 296 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 P 296 8x49 G.H5 D 350 G.H5.22
Hydrophobic C-term P 323 - G.H2 I 212 G.H2.08
Van-der-waals C-term P 323 - G.H2 I 212 G.H2.08
Hydrophobic C-term L 326 - G.H3 S 252 G.H3.11
Polar ICL2 R 122 - G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 R 122 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 R 122 - G.s2s3 K 192 G.s2s3.01
Hydrophobic C-term L 327 - G.H2 R 208 G.H2.04
Hydrophobic TM3 R 113 3x50 G.H5 C 351 G.H5.23
Polar C-term L 330 - G.H2 R 208 G.H2.04
Hydrophobic C-term L 330 - G.H2 R 208 G.H2.04
Van-der-waals C-term L 330 - G.H2 R 208 G.H2.04
Hydrophobic ICL3 S 217 - G.H4 Y 296 G.H4.03
Van-der-waals ICL3 S 217 - G.H4 Y 296 G.H4.03
Polar C-term W 321 - G.H3 H 256 G.H3.15
Aromatic C-term W 321 - G.H3 H 256 G.H3.15
Hydrophobic C-term W 321 - G.H3 H 256 G.H3.15
Van-der-waals C-term W 321 - G.H3 H 256 G.H3.15
Hydrophobic TM5 P 207 5x73 G.S6 Y 320 G.S6.02
Hydrophobic TM5 A 203 5x69 G.H5 F 354 G.H5.26
Hydrophobic C-term L 330 - G.H3 I 253 G.H3.12
Polar C-term Q 331 - G.H2 K 209 G.H2.05
Hydrophobic C-term Q 331 - G.H2 K 209 G.H2.05
Van-der-waals C-term Q 331 - G.H2 K 209 G.H2.05
Hydrophobic TM5 Y 192 5x58 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 224 - G.S6 M 323 G.S6.05
Hydrophobic C-term L 330 - G.H3 L 249 G.H3.08
Van-der-waals C-term L 330 - G.H3 L 249 G.H3.08
Ionic TM6 R 233 6x27 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 233 6x27 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 233 6x27 G.h4s6 D 315 G.h4s6.09
Aromatic C-term W 321 - G.H3 F 258 G.H3.17
Hydrophobic C-term W 321 - G.H3 F 258 G.H3.17
Van-der-waals C-term W 321 - G.H3 F 258 G.H3.17
Hydrophobic TM6 A 242 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 A 242 6x36 G.H5 G 352 G.H5.24
Polar ICL1 G 44 - G.HN D 28 G.HN.52
Hydrophobic TM5 V 198 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 V 198 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 121 - G.S3 F 196 G.S3.03
Hydrophobic ICL2 P 123 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL3 L 227 - G.H4 L 308 G.H4.16
Van-der-waals ICL3 L 227 - G.H4 L 308 G.H4.16
Hydrophobic TM3 I 117 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 117 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 121 - G.H5 T 340 G.H5.12
Polar TM7 L 293 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 L 293 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 L 293 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM3 L 116 3x53 G.H5 C 351 G.H5.23
Van-der-waals ICL1 G 44 - G.HN Q 24 G.HN.48
Hydrophobic ICL2 P 123 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 P 123 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 121 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 L 121 - G.s2s3 K 192 G.s2s3.01
Van-der-waals C-term C 329 - G.H3 H 248 G.H3.07
Van-der-waals H8 Q 294 8x47 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 120 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 120 - G.H5 I 344 G.H5.16
Hydrophobic C-term L 326 - G.H3 H 256 G.H3.15
Van-der-waals C-term L 326 - G.H3 H 256 G.H3.15
Hydrophobic ICL2 L 121 - G.S2 V 191 G.S2.08
Van-der-waals ICL2 L 121 - G.S2 V 191 G.S2.08
Hydrophobic H8 R 295 8x48 G.H5 K 349 G.H5.21
Ionic H8 R 295 8x48 G.H5 E 346 G.H5.18
Polar H8 R 295 8x48 G.H5 E 346 G.H5.18
Van-der-waals H8 R 295 8x48 G.H5 E 346 G.H5.18
Hydrophobic TM6 A 242 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 242 6x36 G.H5 L 353 G.H5.25
Hydrophobic H8 Q 294 8x47 G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 224 - G.H4 N 301 G.H4.08
Van-der-waals ICL3 L 224 - G.H4 N 301 G.H4.08
Hydrophobic TM5 A 210 5x76 G.H5 F 334 G.H5.06
Van-der-waals TM5 A 210 5x76 G.H5 F 334 G.H5.06
Hydrophobic TM5 I 195 5x61 G.H5 L 348 G.H5.20
Hydrophobic C-term P 334 - G.s4h3 V 240 G.s4h3.14
Hydrophobic C-term W 321 - G.H2 I 212 G.H2.08
Van-der-waals C-term W 321 - G.H2 I 212 G.H2.08
Hydrophobic ICL2 P 120 - G.H5 T 340 G.H5.12
Polar ICL3 L 224 - G.H4 K 304 G.H4.12
Van-der-waals ICL3 L 224 - G.H4 K 304 G.H4.12
Ionic ICL2 R 126 - G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 126 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 126 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 126 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL1 G 44 - G.hns1 A 31 G.hns1.02
Polar ICL3 R 223 - G.H4 D 297 G.H4.04
Hydrophobic ICL3 R 223 - G.H4 D 297 G.H4.04
Van-der-waals ICL3 R 223 - G.H4 D 297 G.H4.04
Hydrophobic C-term L 326 - G.H3 I 253 G.H3.12
Polar ICL2 L 121 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 L 121 - G.H5 F 336 G.H5.08
Polar ICL3 L 224 - G.H4 D 297 G.H4.04
Hydrophobic ICL3 L 224 - G.H4 D 297 G.H4.04
Van-der-waals ICL3 L 224 - G.H4 D 297 G.H4.04
Hydrophobic ICL3 L 227 - G.H4 K 304 G.H4.12
Van-der-waals ICL3 L 227 - G.H4 K 304 G.H4.12
Ionic ICL3 R 223 - G.H4 D 298 G.H4.05
Polar ICL3 R 223 - G.H4 D 298 G.H4.05
Hydrophobic TM5 A 202 5x68 G.H5 L 348 G.H5.20
Hydrophobic ICL3 S 217 - G.H4 D 297 G.H4.04
Van-der-waals ICL3 S 217 - G.H4 D 297 G.H4.04
Hydrophobic TM5 P 207 5x73 G.S6 H 322 G.S6.04
Hydrophobic C-term P 333 - G.H2 R 205 G.H2.01
Hydrophobic C-term L 327 - G.H2 K 209 G.H2.05
Van-der-waals C-term L 327 - G.H2 K 209 G.H2.05
Hydrophobic C-term P 334 - G.H3 H 248 G.H3.07
Hydrophobic ICL3 L 224 - G.H4 Y 296 G.H4.03
Van-der-waals ICL3 L 224 - G.H4 Y 296 G.H4.03
Hydrophobic TM3 I 117 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 224 - G.H4 G 300 G.H4.07
Van-der-waals ICL3 L 224 - G.H4 G 300 G.H4.07
Hydrophobic ICL1 P 43 - G.HN Q 24 G.HN.48
Van-der-waals ICL1 P 43 - G.HN Q 24 G.HN.48
Polar TM2 R 46 2x38 G.hns1 A 31 G.hns1.02
Van-der-waals TM2 R 46 2x38 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 120 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 120 - G.H5 I 343 G.H5.15
Polar TM2 R 46 2x38 G.H5 N 347 G.H5.19
Van-der-waals TM2 R 46 2x38 G.H5 N 347 G.H5.19
Hydrophobic TM5 A 199 5x65 G.H5 L 348 G.H5.20
Polar TM3 L 116 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 116 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 116 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 123 - G.hns1 K 32 G.hns1.03
Hydrophobic C-term P 334 - G.H2 R 205 G.H2.01
Van-der-waals C-term P 334 - G.H2 R 205 G.H2.01
Hydrophobic TM3 I 117 3x54 G.H5 C 351 G.H5.23
Hydrophobic C-term L 326 - G.h2s4 F 215 G.h2s4.01
Van-der-waals C-term L 326 - G.h2s4 F 215 G.h2s4.01
Hydrophobic C-term L 330 - G.H2 W 211 G.H2.07
Hydrophobic ICL1 P 43 - G.HN A 27 G.HN.51
Hydrophobic ICL1 G 44 - G.HN A 27 G.HN.51
Hydrophobic ICL2 L 121 - G.H5 I 343 G.H5.15
Hydrophobic TM6 P 243 6x37 G.H5 L 353 G.H5.25