GproteinDb

G_i1 - GPR63 complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G_i/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

(pLDDT score) avg.: 73.4

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.5

iPTM Score: 0.3

PAE mean: 25.0

GPCR - G protein interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Gα segment	AA	Number	Generic number

Aromatic	C-term	Y	410	-	G.H2	H	213	G.H2.09
Hydrophobic	TM3	I	182	3x53	G.H5	F	354	G.H5.26
Hydrophobic	ICL2	R	186	-	G.H5	D	337	G.H5.09
Hydrophobic	TM6	K	309	6x30	G.H5	V	342	G.H5.14
Hydrophobic	TM2	S	114	2x37	G.H5	L	353	G.H5.25
Hydrophobic	TM2	A	115	2x38	G.H5	L	353	G.H5.25
Hydrophobic	C-term	R	402	-	G.h2s4	E	216	G.h2s4.02
Hydrophobic	TM3	R	179	3x50	G.H5	F	354	G.H5.26
Hydrophobic	TM6	D	305	6x26	G.h4s6	E	318	G.h4s6.12
Hydrophobic	TM3	I	182	3x53	G.H5	I	344	G.H5.16
Hydrophobic	ICL3	M	302	-	G.H4	E	308	G.H4.16
Hydrophobic	ICL2	R	186	-	G.s2s3	K	192	G.s2s3.01
Hydrophobic	TM6	K	309	6x30	G.S6	Y	320	G.S6.02
Hydrophobic	ICL2	L	190	-	G.hns1	R	32	G.hns1.03
Hydrophobic	TM6	K	309	6x30	G.H5	K	349	G.H5.21
Hydrophobic	TM6	F	308	6x29	G.h3s5	D	261	G.h3s5.02
Hydrophobic	C-term	Y	410	-	G.H2	H	213	G.H2.09
Hydrophobic	C-term	R	402	-	G.h2s4	F	215	G.h2s4.01
Hydrophobic	TM6	M	306	6x27	G.H5	K	345	G.H5.17
Hydrophobic	ICL3	I	283	-	G.H4	E	297	G.H4.04
Hydrophobic	TM6	R	311	6x32	G.H5	D	350	G.H5.22
Hydrophobic	H8	I	375	8x47	G.H5	C	351	G.H5.23
Hydrophobic	ICL2	D	188	-	G.H5	F	354	G.H5.26
Hydrophobic	TM6	A	312	6x33	G.H5	K	349	G.H5.21
Hydrophobic	C-term	I	404	-	G.h2s4	E	216	G.h2s4.02
Hydrophobic	TM6	F	308	6x29	G.H5	D	350	G.H5.22
Hydrophobic	ICL3	L	285	-	G.H4	E	298	G.H4.05
Hydrophobic	ICL3	L	285	-	G.hgh4	S	293	G.hgh4.08
Hydrophobic	H8	K	376	8x48	G.h3s5	D	261	G.h3s5.02
Hydrophobic	ICL2	D	188	-	G.s2s3	D	193	G.s2s3.02
Hydrophobic	TM6	K	309	6x30	G.H5	K	345	G.H5.17
Hydrophobic	TM2	S	114	2x37	G.hns1	A	31	G.hns1.02
Hydrophobic	TM4	N	191	4x38	G.HN	E	28	G.HN.52
Hydrophobic	H8	K	377	8x49	G.H5	C	351	G.H5.23
Hydrophobic	ICL2	R	186	-	G.H5	D	341	G.H5.13
Hydrophobic	ICL3	L	285	-	G.H4	T	295	G.H4.02
Hydrophobic	TM2	I	116	2x39	G.H5	G	352	G.H5.24
Hydrophobic	TM2	I	116	2x39	G.H5	L	353	G.H5.25
Hydrophobic	C-term	R	402	-	G.h2s4	G	217	G.h2s4.03
Hydrophobic	ICL2	D	188	-	G.hns1	R	32	G.hns1.03
Hydrophobic	TM4	P	192	4x39	G.HN	E	28	G.HN.52
Hydrophobic	TM2	L	120	2x43	G.H5	G	352	G.H5.24
Hydrophobic	TM6	A	312	6x33	G.H5	D	350	G.H5.22
Hydrophobic	TM6	F	308	6x29	G.H5	N	347	G.H5.19
Hydrophobic	TM4	K	196	4x43	G.HN	R	24	G.HN.48
Hydrophobic	C-term	T	400	-	G.H3	W	258	G.H3.17
Hydrophobic	C-term	R	402	-	G.H3	W	258	G.H3.17
Hydrophobic	TM3	I	183	3x54	G.H5	K	349	G.H5.21
Hydrophobic	TM5	L	269	5x65	G.H5	K	345	G.H5.17
Hydrophobic	TM6	I	304	6x25	G.h4s6	E	318	G.h4s6.12
Hydrophobic	H8	I	375	8x47	G.H5	G	352	G.H5.24
Hydrophobic	TM6	F	308	6x29	G.H5	N	346	G.H5.18
Hydrophobic	TM3	R	179	3x50	G.H5	L	353	G.H5.25
Hydrophobic	TM6	K	309	6x30	G.H5	N	346	G.H5.18
Ionic	ICL2	R	186	-	G.H5	D	337	G.H5.09
Ionic	TM6	R	311	6x32	G.H5	D	350	G.H5.22
Ionic	H8	K	376	8x48	G.h3s5	D	261	G.h3s5.02
Ionic	TM6	R	311	6x32	G.h3s5	D	261	G.h3s5.02
Ionic	ICL2	R	186	-	G.H5	D	341	G.H5.13
Ionic	ICL2	D	188	-	G.hns1	R	32	G.hns1.03
Ionic	ICL1	R	113	12x51	G.HN	D	20	G.HN.44
Polar	TM4	P	192	4x39	G.HN	R	24	G.HN.48
Polar	ICL2	R	186	-	G.H5	D	337	G.H5.09
Polar	TM3	R	179	3x50	G.H5	F	354	G.H5.26
Polar	ICL2	L	190	-	G.hns1	R	32	G.hns1.03
Polar	TM6	K	309	6x30	G.H5	K	349	G.H5.21
Polar	C-term	Y	410	-	G.H2	H	213	G.H2.09
Polar	C-term	R	402	-	G.h2s4	F	215	G.h2s4.01
Polar	C-term	R	403	-	G.h2s4	E	216	G.h2s4.02
Polar	TM4	Y	193	4x40	G.HN	E	28	G.HN.52
Polar	TM6	R	311	6x32	G.H5	D	350	G.H5.22
Polar	C-term	I	404	-	G.h2s4	E	216	G.h2s4.02
Polar	H8	K	376	8x48	G.h3s5	D	261	G.h3s5.02
Polar	ICL2	D	188	-	G.s2s3	D	193	G.s2s3.02
Polar	TM4	N	191	4x38	G.HN	E	28	G.HN.52
Polar	H8	K	377	8x49	G.H5	C	351	G.H5.23
Polar	ICL2	R	186	-	G.H5	D	341	G.H5.13
Polar	C-term	R	402	-	G.h2s4	V	218	G.h2s4.04
Polar	ICL2	D	188	-	G.hns1	R	32	G.hns1.03
Polar	TM4	P	192	4x39	G.HN	E	28	G.HN.52
Polar	TM6	A	312	6x33	G.H5	D	350	G.H5.22
Polar	ICL2	K	189	-	G.hns1	R	32	G.hns1.03
Polar	TM5	L	269	5x65	G.H5	K	345	G.H5.17
Polar	ICL1	R	113	12x51	G.HN	D	20	G.HN.44
Polar	TM3	R	179	3x50	G.H5	L	353	G.H5.25
Polar	TM5	N	272	5x68	G.H5	D	341	G.H5.13
Polar	TM6	K	309	6x30	G.H5	N	346	G.H5.18
Van-der-waals	TM3	I	182	3x53	G.H5	F	354	G.H5.26
Van-der-waals	ICL2	R	186	-	G.H5	D	337	G.H5.09
Van-der-waals	TM6	K	309	6x30	G.H5	V	342	G.H5.14
Van-der-waals	TM2	S	114	2x37	G.H5	L	353	G.H5.25
Van-der-waals	C-term	R	402	-	G.h2s4	E	216	G.h2s4.02
Van-der-waals	TM3	R	179	3x50	G.H5	F	354	G.H5.26
Van-der-waals	TM6	D	305	6x26	G.h4s6	E	318	G.h4s6.12
Van-der-waals	TM3	I	182	3x53	G.H5	I	344	G.H5.16
Van-der-waals	ICL2	R	186	-	G.s2s3	K	192	G.s2s3.01
Van-der-waals	ICL2	L	190	-	G.hns1	R	32	G.hns1.03
Van-der-waals	TM6	K	309	6x30	G.H5	K	349	G.H5.21
Van-der-waals	TM6	F	308	6x29	G.h3s5	D	261	G.h3s5.02
Van-der-waals	C-term	Y	410	-	G.H2	H	213	G.H2.09
Van-der-waals	C-term	R	402	-	G.h2s4	F	215	G.h2s4.01
Van-der-waals	TM6	M	306	6x27	G.H5	K	345	G.H5.17
Van-der-waals	ICL3	I	283	-	G.H4	E	297	G.H4.04
Van-der-waals	TM4	Y	193	4x40	G.HN	E	28	G.HN.52
Van-der-waals	TM6	R	311	6x32	G.H5	D	350	G.H5.22
Van-der-waals	ICL2	D	188	-	G.H5	F	354	G.H5.26
Van-der-waals	TM6	A	312	6x33	G.H5	K	349	G.H5.21
Van-der-waals	C-term	I	404	-	G.h2s4	E	216	G.h2s4.02
Van-der-waals	TM6	F	308	6x29	G.H5	D	350	G.H5.22
Van-der-waals	ICL3	L	285	-	G.H4	E	298	G.H4.05
Van-der-waals	ICL3	L	285	-	G.hgh4	S	293	G.hgh4.08
Van-der-waals	H8	K	376	8x48	G.h3s5	D	261	G.h3s5.02
Van-der-waals	ICL2	D	188	-	G.s2s3	D	193	G.s2s3.02
Van-der-waals	TM6	K	309	6x30	G.H5	K	345	G.H5.17
Van-der-waals	TM4	N	191	4x38	G.HN	E	28	G.HN.52
Van-der-waals	H8	K	377	8x49	G.H5	C	351	G.H5.23
Van-der-waals	ICL2	R	186	-	G.H5	D	341	G.H5.13
Van-der-waals	TM2	N	117	2x40	G.H5	C	351	G.H5.23
Van-der-waals	ICL3	L	285	-	G.H4	T	295	G.H4.02
Van-der-waals	C-term	R	402	-	G.h2s4	V	218	G.h2s4.04
Van-der-waals	TM2	I	116	2x39	G.H5	G	352	G.H5.24
Van-der-waals	TM2	I	116	2x39	G.H5	L	353	G.H5.25
Van-der-waals	C-term	R	402	-	G.h2s4	G	217	G.h2s4.03
Van-der-waals	ICL2	D	188	-	G.hns1	R	32	G.hns1.03
Van-der-waals	TM4	P	192	4x39	G.HN	E	28	G.HN.52
Van-der-waals	ICL2	K	189	-	G.hns1	R	32	G.hns1.03
Van-der-waals	TM4	K	196	4x43	G.HN	R	24	G.HN.48
Van-der-waals	C-term	T	400	-	G.H3	W	258	G.H3.17
Van-der-waals	C-term	R	402	-	G.H3	W	258	G.H3.17
Van-der-waals	TM3	I	183	3x54	G.H5	K	349	G.H5.21
Van-der-waals	TM5	L	269	5x65	G.H5	K	345	G.H5.17
Van-der-waals	TM6	I	304	6x25	G.h4s6	E	318	G.h4s6.12
Van-der-waals	ICL2	Q	187	-	G.s2s3	D	193	G.s2s3.02
Van-der-waals	H8	I	375	8x47	G.H5	G	352	G.H5.24
Van-der-waals	TM6	F	308	6x29	G.H5	N	346	G.H5.18
Van-der-waals	TM3	R	179	3x50	G.H5	L	353	G.H5.25
Van-der-waals	TM5	N	272	5x68	G.H5	D	341	G.H5.13
Van-der-waals	TM6	K	309	6x30	G.H5	N	346	G.H5.18

Showing 1 to 138 of 138 entries

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Main reference

Gi1 - GPR63 complex model Download Full