Gi1 - GPR63 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 73.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 L 190 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 190 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 190 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 K 309 6x30 G.S6 Y 320 G.S6.02
Hydrophobic C-term R 402 - G.H3 W 258 G.H3.17
Van-der-waals C-term R 402 - G.H3 W 258 G.H3.17
Hydrophobic C-term T 400 - G.H3 W 258 G.H3.17
Van-der-waals C-term T 400 - G.H3 W 258 G.H3.17
Ionic H8 K 376 8x48 G.h3s5 D 261 G.h3s5.02
Polar H8 K 376 8x48 G.h3s5 D 261 G.h3s5.02
Hydrophobic H8 K 376 8x48 G.h3s5 D 261 G.h3s5.02
Van-der-waals H8 K 376 8x48 G.h3s5 D 261 G.h3s5.02
Polar TM6 A 312 6x33 G.H5 D 350 G.H5.22
Hydrophobic TM6 A 312 6x33 G.H5 D 350 G.H5.22
Polar TM6 K 309 6x30 G.H5 K 349 G.H5.21
Hydrophobic TM6 K 309 6x30 G.H5 K 349 G.H5.21
Van-der-waals TM6 K 309 6x30 G.H5 K 349 G.H5.21
Polar H8 K 377 8x49 G.H5 C 351 G.H5.23
Hydrophobic H8 K 377 8x49 G.H5 C 351 G.H5.23
Van-der-waals H8 K 377 8x49 G.H5 C 351 G.H5.23
Hydrophobic TM6 F 308 6x29 G.h3s5 D 261 G.h3s5.02
Van-der-waals TM6 F 308 6x29 G.h3s5 D 261 G.h3s5.02
Polar C-term R 402 - G.h2s4 F 215 G.h2s4.01
Hydrophobic C-term R 402 - G.h2s4 F 215 G.h2s4.01
Van-der-waals C-term R 402 - G.h2s4 F 215 G.h2s4.01
Hydrophobic ICL3 L 285 - G.hgh4 S 293 G.hgh4.08
Van-der-waals ICL3 L 285 - G.hgh4 S 293 G.hgh4.08
Hydrophobic TM3 I 182 3x53 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 182 3x53 G.H5 I 344 G.H5.16
Hydrophobic H8 I 375 8x47 G.H5 C 351 G.H5.23
Hydrophobic ICL3 I 283 - G.H4 E 297 G.H4.04
Van-der-waals ICL3 I 283 - G.H4 E 297 G.H4.04
Polar C-term I 404 - G.h2s4 E 216 G.h2s4.02
Hydrophobic C-term I 404 - G.h2s4 E 216 G.h2s4.02
Van-der-waals C-term I 404 - G.h2s4 E 216 G.h2s4.02
Hydrophobic TM3 I 183 3x54 G.H5 K 349 G.H5.21
Van-der-waals TM3 I 183 3x54 G.H5 K 349 G.H5.21
Polar TM3 R 179 3x50 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 179 3x50 G.H5 F 354 G.H5.26
Van-der-waals TM3 R 179 3x50 G.H5 F 354 G.H5.26
Van-der-waals ICL2 Q 187 - G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 189 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 189 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 K 309 6x30 G.H5 V 342 G.H5.14
Van-der-waals TM6 K 309 6x30 G.H5 V 342 G.H5.14
Hydrophobic TM4 K 196 4x43 G.HN R 24 G.HN.48
Van-der-waals TM4 K 196 4x43 G.HN R 24 G.HN.48
Hydrophobic TM2 L 120 2x43 G.H5 G 352 G.H5.24
Hydrophobic ICL3 L 285 - G.H4 T 295 G.H4.02
Van-der-waals ICL3 L 285 - G.H4 T 295 G.H4.02
Polar TM4 N 191 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 N 191 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 N 191 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 A 312 6x33 G.H5 K 349 G.H5.21
Van-der-waals TM6 A 312 6x33 G.H5 K 349 G.H5.21
Polar C-term R 403 - G.h2s4 E 216 G.h2s4.02
Hydrophobic ICL3 M 302 - G.H4 E 308 G.H4.16
Polar ICL2 D 188 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 D 188 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 D 188 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL3 L 285 - G.H4 E 298 G.H4.05
Van-der-waals ICL3 L 285 - G.H4 E 298 G.H4.05
Polar TM4 P 192 4x39 G.HN E 28 G.HN.52
Hydrophobic TM4 P 192 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 P 192 4x39 G.HN E 28 G.HN.52
Hydrophobic TM6 I 304 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 I 304 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 M 306 6x27 G.H5 K 345 G.H5.17
Van-der-waals TM6 M 306 6x27 G.H5 K 345 G.H5.17
Polar TM3 R 179 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 179 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 179 3x50 G.H5 L 353 G.H5.25
Hydrophobic C-term R 402 - G.h2s4 E 216 G.h2s4.02
Van-der-waals C-term R 402 - G.h2s4 E 216 G.h2s4.02
Polar TM4 Y 193 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 Y 193 4x40 G.HN E 28 G.HN.52
Hydrophobic C-term R 402 - G.h2s4 G 217 G.h2s4.03
Van-der-waals C-term R 402 - G.h2s4 G 217 G.h2s4.03
Ionic ICL1 R 113 12x51 G.HN D 20 G.HN.44
Polar ICL1 R 113 12x51 G.HN D 20 G.HN.44
Polar TM5 L 269 5x65 G.H5 K 345 G.H5.17
Hydrophobic TM5 L 269 5x65 G.H5 K 345 G.H5.17
Van-der-waals TM5 L 269 5x65 G.H5 K 345 G.H5.17
Ionic TM6 R 311 6x32 G.h3s5 D 261 G.h3s5.02
Ionic ICL2 R 186 - G.H5 D 341 G.H5.13
Polar ICL2 R 186 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 R 186 - G.H5 D 341 G.H5.13
Van-der-waals ICL2 R 186 - G.H5 D 341 G.H5.13
Hydrophobic TM2 I 116 2x39 G.H5 L 353 G.H5.25
Van-der-waals TM2 I 116 2x39 G.H5 L 353 G.H5.25
Hydrophobic TM2 A 115 2x38 G.H5 L 353 G.H5.25
Van-der-waals TM2 N 117 2x40 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 186 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 R 186 - G.s2s3 K 192 G.s2s3.01
Ionic TM6 R 311 6x32 G.H5 D 350 G.H5.22
Polar TM6 R 311 6x32 G.H5 D 350 G.H5.22
Hydrophobic TM6 R 311 6x32 G.H5 D 350 G.H5.22
Van-der-waals TM6 R 311 6x32 G.H5 D 350 G.H5.22
Hydrophobic TM2 I 116 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 I 116 2x39 G.H5 G 352 G.H5.24
Hydrophobic TM2 S 114 2x37 G.H5 L 353 G.H5.25
Van-der-waals TM2 S 114 2x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 D 188 - G.H5 F 354 G.H5.26
Van-der-waals ICL2 D 188 - G.H5 F 354 G.H5.26
Hydrophobic TM3 I 182 3x53 G.H5 F 354 G.H5.26
Van-der-waals TM3 I 182 3x53 G.H5 F 354 G.H5.26
Polar TM4 P 192 4x39 G.HN R 24 G.HN.48
Hydrophobic TM6 F 308 6x29 G.H5 N 347 G.H5.19
Hydrophobic TM6 F 308 6x29 G.H5 D 350 G.H5.22
Van-der-waals TM6 F 308 6x29 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 114 2x37 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 F 308 6x29 G.H5 N 346 G.H5.18
Van-der-waals TM6 F 308 6x29 G.H5 N 346 G.H5.18
Polar C-term R 402 - G.h2s4 V 218 G.h2s4.04
Van-der-waals C-term R 402 - G.h2s4 V 218 G.h2s4.04
Hydrophobic TM6 D 305 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 D 305 6x26 G.h4s6 E 318 G.h4s6.12
Ionic ICL2 D 188 - G.hns1 R 32 G.hns1.03
Polar ICL2 D 188 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 188 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 188 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 I 375 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 I 375 8x47 G.H5 G 352 G.H5.24
Ionic ICL2 R 186 - G.H5 D 337 G.H5.09
Polar ICL2 R 186 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 R 186 - G.H5 D 337 G.H5.09
Van-der-waals ICL2 R 186 - G.H5 D 337 G.H5.09
Hydrophobic TM6 K 309 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 K 309 6x30 G.H5 K 345 G.H5.17
Polar TM6 K 309 6x30 G.H5 N 346 G.H5.18
Hydrophobic TM6 K 309 6x30 G.H5 N 346 G.H5.18
Van-der-waals TM6 K 309 6x30 G.H5 N 346 G.H5.18
Polar C-term Y 410 - G.H2 H 213 G.H2.09
Aromatic C-term Y 410 - G.H2 H 213 G.H2.09
Hydrophobic C-term Y 410 - G.H2 H 213 G.H2.09
Van-der-waals C-term Y 410 - G.H2 H 213 G.H2.09
Polar TM5 N 272 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 N 272 5x68 G.H5 D 341 G.H5.13