GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 74.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 20.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | H | 399 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Hydrophobic | C-term | H | 399 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Van-der-waals | C-term | H | 399 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Hydrophobic | ICL3 | M | 302 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | ICL3 | M | 302 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | TM6 | I | 304 | 6x25 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM6 | I | 304 | 6x25 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | C-term | V | 418 | - | H.hbhc | E | 119 | H.hbhc.01 |
Van-der-waals | TM6 | R | 311 | 6x32 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | R | 405 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Hydrophobic | C-term | R | 405 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Van-der-waals | C-term | R | 405 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Hydrophobic | TM6 | K | 309 | 6x30 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM6 | S | 303 | 6x24 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | TM6 | S | 303 | 6x24 | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | TM6 | T | 315 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | T | 315 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | T | 315 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Polar | H8 | K | 377 | 8x49 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | H8 | K | 377 | 8x49 | G.H5 | K | 354 | G.H5.21 |
Polar | C-term | R | 402 | - | G.H3 | P | 262 | G.H3.16 |
Hydrophobic | C-term | R | 402 | - | G.H3 | P | 262 | G.H3.16 |
Van-der-waals | C-term | R | 402 | - | G.H3 | P | 262 | G.H3.16 |
Hydrophobic | TM6 | R | 311 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | R | 311 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Polar | C-term | H | 415 | - | G.hfs2 | T | 187 | G.hfs2.06 |
Hydrophobic | TM2 | I | 116 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | I | 116 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | S | 303 | 6x24 | G.S6 | Y | 325 | G.S6.02 |
Polar | H8 | K | 377 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | H8 | K | 377 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Polar | C-term | R | 402 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | C-term | R | 402 | - | G.H3 | W | 263 | G.H3.17 |
Van-der-waals | C-term | R | 402 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | TM6 | F | 308 | 6x29 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM6 | I | 304 | 6x25 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | TM6 | I | 304 | 6x25 | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | TM3 | I | 183 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | H8 | I | 375 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | I | 304 | 6x25 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | H8 | I | 375 | 8x47 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM2 | A | 115 | 2x38 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM2 | N | 117 | 2x40 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM2 | N | 117 | 2x40 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | N | 117 | 2x40 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | C | 412 | - | G.S2 | I | 189 | G.S2.01 |
Van-der-waals | C-term | C | 412 | - | G.S2 | I | 189 | G.S2.01 |
Polar | ICL2 | L | 190 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | TM6 | S | 303 | 6x24 | G.S6 | I | 324 | G.S6.01 |
Polar | TM2 | S | 114 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | S | 114 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM3 | R | 179 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | R | 179 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | P | 406 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Hydrophobic | C-term | P | 406 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Van-der-waals | C-term | P | 406 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Hydrophobic | ICL3 | M | 302 | - | G.H5 | A | 342 | G.H5.09 |
Polar | TM5 | Y | 279 | 5x75 | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | TM5 | Y | 279 | 5x75 | G.S6 | H | 327 | G.S6.04 |
Van-der-waals | TM5 | Y | 279 | 5x75 | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | TM3 | I | 182 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Polar | ICL2 | D | 188 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | D | 188 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | R | 403 | - | G.H3 | W | 263 | G.H3.17 |
Van-der-waals | C-term | R | 403 | - | G.H3 | W | 263 | G.H3.17 |
Polar | H8 | K | 377 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | K | 377 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | K | 377 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL3 | M | 302 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | ICL3 | M | 302 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | TM3 | I | 182 | 3x53 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | I | 182 | 3x53 | G.H5 | L | 349 | G.H5.16 |
Aromatic | TM3 | R | 179 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 179 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 179 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | A | 312 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | A | 312 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM3 | R | 179 | 3x50 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | H8 | I | 375 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | I | 375 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL2 | L | 190 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | L | 190 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | L | 190 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | D | 305 | 6x26 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | TM6 | D | 305 | 6x26 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | ICL2 | R | 186 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM6 | A | 312 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | A | 312 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM6 | F | 308 | 6x29 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM6 | F | 308 | 6x29 | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | C-term | T | 400 | - | G.H3 | P | 262 | G.H3.16 |
Van-der-waals | C-term | T | 400 | - | G.H3 | P | 262 | G.H3.16 |
Polar | H8 | K | 376 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | H8 | K | 376 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | K | 376 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL3 | M | 302 | - | G.H5 | A | 343 | G.H5.10 |
Van-der-waals | ICL3 | M | 302 | - | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | TM3 | I | 183 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | I | 183 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | I | 404 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Van-der-waals | C-term | I | 404 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Hydrophobic | C-term | R | 402 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Van-der-waals | C-term | R | 402 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | TM3 | I | 182 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | I | 182 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM6 | A | 312 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | A | 312 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | A | 312 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Ionic | TM6 | R | 311 | 6x32 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | TM6 | R | 311 | 6x32 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM6 | R | 311 | 6x32 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | TM6 | R | 311 | 6x32 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM6 | F | 308 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | F | 308 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | I | 404 | - | G.H3 | W | 263 | G.H3.17 |
Van-der-waals | C-term | I | 404 | - | G.H3 | W | 263 | G.H3.17 |
Polar | TM5 | Y | 279 | 5x75 | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | TM5 | Y | 279 | 5x75 | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | TM6 | K | 309 | 6x30 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | C-term | R | 402 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Ionic | ICL2 | D | 188 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL2 | D | 188 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | D | 188 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | D | 188 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | TM3 | R | 179 | 3x50 | G.H5 | N | 352 | G.H5.19 |
Aromatic | ICL3 | F | 300 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | ICL3 | F | 300 | - | G.S6 | H | 327 | G.S6.04 |
Van-der-waals | ICL3 | F | 300 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | TM6 | F | 308 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | F | 308 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | ICL3 | M | 302 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | ICL3 | M | 302 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | H8 | F | 378 | 8x50 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | F | 378 | 8x50 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | R | 402 | - | G.h3s5 | S | 267 | G.h3s5.03 |
Van-der-waals | C-term | R | 402 | - | G.h3s5 | S | 267 | G.h3s5.03 |
Aromatic | ICL3 | F | 300 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ICL3 | F | 300 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | ICL3 | F | 300 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ICL3 | F | 300 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | TM6 | I | 316 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | I | 316 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | R | 402 | - | G.H3 | F | 264 | G.H3.18 |
Van-der-waals | C-term | R | 402 | - | G.H3 | F | 264 | G.H3.18 |
Hydrophobic | ICL2 | R | 186 | - | G.H5 | L | 349 | G.H5.16 |
Polar | TM6 | D | 305 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | I | 304 | 6x25 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | I | 304 | 6x25 | G.H5 | Q | 350 | G.H5.17 |
Ionic | TM6 | K | 309 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Polar | TM6 | K | 309 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM6 | K | 309 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM6 | K | 309 | 6x30 | G.H5 | D | 346 | G.H5.13 |
Polar | C-term | Y | 410 | - | G.H2 | H | 218 | G.H2.09 |
Aromatic | C-term | Y | 410 | - | G.H2 | H | 218 | G.H2.09 |
Hydrophobic | C-term | Y | 410 | - | G.H2 | H | 218 | G.H2.09 |
Van-der-waals | C-term | Y | 410 | - | G.H2 | H | 218 | G.H2.09 |