GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | R | 166 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 166 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 166 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM6 | L | 266 | 6x22 | G.h4s6 | K | 314 | G.h4s6.08 |
Polar | ICL3 | C | 265 | - | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | ICL3 | C | 265 | - | G.H4 | C | 305 | G.H4.13 |
Van-der-waals | ICL3 | C | 265 | - | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | TM6 | L | 281 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | Y | 177 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | Y | 177 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Ionic | TM5 | H | 255 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | H | 255 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | H | 255 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | H | 255 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | L | 170 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | Y | 177 | 34x54 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM6 | A | 273 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | A | 273 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | L | 174 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | ICL2 | A | 173 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | A | 173 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | Y | 177 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | Y | 177 | 34x54 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | C-term | P | 359 | - | G.H2 | I | 212 | G.H2.08 |
Ionic | ICL2 | R | 179 | 34x56 | G.HN | E | 25 | G.HN.49 |
Polar | ICL2 | R | 179 | 34x56 | G.HN | E | 25 | G.HN.49 |
Hydrophobic | ICL2 | R | 179 | 34x56 | G.HN | E | 25 | G.HN.49 |
Van-der-waals | ICL2 | R | 179 | 34x56 | G.HN | E | 25 | G.HN.49 |
Polar | ICL3 | Q | 262 | - | G.H4 | Q | 304 | G.H4.12 |
Van-der-waals | ICL3 | Q | 262 | - | G.H4 | Q | 304 | G.H4.12 |
Hydrophobic | TM6 | T | 280 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 280 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | M | 107 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | M | 107 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Polar | ICL3 | Q | 262 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | ICL3 | Q | 262 | - | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | ICL3 | Q | 262 | - | G.S6 | H | 322 | G.S6.04 |
Polar | C-term | S | 356 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | C-term | S | 356 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | S | 356 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | ICL2 | T | 175 | 34x52 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | T | 175 | 34x52 | G.s2s3 | K | 192 | G.s2s3.01 |
Polar | TM5 | H | 255 | 5x68 | G.H5 | K | 345 | G.H5.17 |
Ionic | ICL1 | R | 104 | 12x51 | G.HN | D | 20 | G.HN.44 |
Polar | ICL1 | R | 104 | 12x51 | G.HN | D | 20 | G.HN.44 |
Hydrophobic | ICL1 | R | 104 | 12x51 | G.HN | D | 20 | G.HN.44 |
Van-der-waals | ICL1 | R | 104 | 12x51 | G.HN | D | 20 | G.HN.44 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 174 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Ionic | ICL2 | R | 179 | 34x56 | G.HN | E | 28 | G.HN.52 |
Polar | ICL2 | R | 179 | 34x56 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | R | 179 | 34x56 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | R | 179 | 34x56 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL3 | C | 265 | - | G.H4 | A | 301 | G.H4.08 |
Hydrophobic | C-term | S | 356 | - | G.H3 | W | 258 | G.H3.17 |
Polar | TM6 | T | 280 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | T | 280 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | T | 280 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | R | 357 | - | G.H3 | W | 258 | G.H3.17 |
Van-der-waals | C-term | R | 357 | - | G.H3 | W | 258 | G.H3.17 |
Hydrophobic | TM5 | H | 255 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | H | 255 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | A | 173 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | A | 173 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM4 | L | 182 | 4x39 | G.HN | R | 24 | G.HN.48 |
Polar | TM3 | S | 169 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | S | 169 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | S | 169 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | ICL3 | Q | 262 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | L | 170 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | L | 170 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | I | 259 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | I | 259 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | H | 255 | 5x68 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | S | 178 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | Y | 177 | 34x54 | G.H5 | D | 350 | G.H5.22 |
Polar | TM3 | S | 169 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM4 | L | 182 | 4x39 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | L | 182 | 4x39 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | H | 186 | 4x43 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | H | 186 | 4x43 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 174 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | V | 252 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | V | 252 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | I | 259 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Polar | TM6 | K | 276 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 276 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 276 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Polar | TM5 | Q | 258 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | L | 170 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | M | 107 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | L | 170 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | T | 175 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 179 | 34x56 | G.hns1 | R | 32 | G.hns1.03 |
Polar | TM6 | G | 277 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | G | 277 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | G | 277 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | H | 255 | 5x68 | G.S6 | Y | 320 | G.S6.02 |
Polar | ICL2 | A | 173 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | I | 248 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM6 | H | 270 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | H | 270 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | H | 270 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | H | 270 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | V | 251 | 5x64 | G.H5 | I | 344 | G.H5.16 |