GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 17.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | T | 175 | 34x52 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | T | 175 | 34x52 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | T | 175 | 34x52 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM5 | Y | 245 | 5x58 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | P | 359 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Polar | ICL2 | L | 174 | 34x51 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | C-term | P | 359 | - | G.H2 | W | 212 | G.H2.07 |
Hydrophobic | C-term | F | 354 | - | G.h4s6 | K | 313 | G.h4s6.03 |
Polar | TM6 | H | 270 | 6x26 | G.H5 | K | 346 | G.H5.17 |
Hydrophobic | TM6 | H | 270 | 6x26 | G.H5 | K | 346 | G.H5.17 |
Van-der-waals | TM6 | H | 270 | 6x26 | G.H5 | K | 346 | G.H5.17 |
Hydrophobic | TM3 | L | 170 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | L | 170 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Polar | ICL3 | Q | 262 | - | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | ICL3 | Q | 262 | - | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM6 | T | 280 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | H | 270 | 6x26 | G.H5 | V | 343 | G.H5.14 |
Hydrophobic | ICL2 | T | 175 | 34x52 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | L | 174 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM5 | I | 248 | 5x61 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | S | 178 | 34x55 | G.hns1 | A | 30 | G.hns1.01 |
Van-der-waals | ICL2 | S | 178 | 34x55 | G.hns1 | A | 30 | G.hns1.01 |
Polar | C-term | R | 357 | - | G.H3 | N | 257 | G.H3.15 |
Polar | C-term | S | 356 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | C-term | S | 356 | - | G.H3 | N | 257 | G.H3.15 |
Polar | C-term | P | 359 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | P | 359 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | P | 359 | - | G.H3 | S | 253 | G.H3.11 |
Polar | ICL2 | R | 180 | 34x57 | G.HN | G | 27 | G.HN.51 |
Hydrophobic | ICL2 | R | 180 | 34x57 | G.HN | G | 27 | G.HN.51 |
Van-der-waals | ICL2 | R | 180 | 34x57 | G.HN | G | 27 | G.HN.51 |
Polar | TM3 | R | 166 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 166 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 166 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Aromatic | C-term | F | 354 | - | G.h4s6 | R | 314 | G.h4s6.04 |
Hydrophobic | C-term | F | 354 | - | G.h4s6 | R | 314 | G.h4s6.04 |
Hydrophobic | TM2 | M | 107 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | TM2 | M | 107 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Ionic | TM5 | H | 255 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | H | 255 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | H | 255 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | H | 255 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | TM3 | R | 166 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM3 | R | 166 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM3 | R | 166 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Polar | ICL2 | L | 174 | 34x51 | G.S1 | V | 34 | G.S1.02 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.S1 | V | 34 | G.S1.02 |
Van-der-waals | ICL2 | L | 174 | 34x51 | G.S1 | V | 34 | G.S1.02 |
Hydrophobic | C-term | V | 362 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | TM6 | H | 270 | 6x26 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | ICL3 | Q | 262 | - | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | TM6 | G | 277 | 6x33 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | C-term | P | 359 | - | G.H3 | I | 254 | G.H3.12 |
Polar | ICL2 | R | 180 | 34x57 | G.HN | L | 23 | G.HN.47 |
Hydrophobic | ICL2 | R | 180 | 34x57 | G.HN | L | 23 | G.HN.47 |
Van-der-waals | ICL2 | R | 180 | 34x57 | G.HN | L | 23 | G.HN.47 |
Hydrophobic | TM2 | M | 107 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM2 | M | 107 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Ionic | TM6 | H | 270 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Ionic | H8 | R | 338 | 8x52 | G.h4s6 | D | 316 | G.h4s6.09 |
Polar | H8 | R | 338 | 8x52 | G.h4s6 | D | 316 | G.h4s6.09 |
Van-der-waals | H8 | R | 338 | 8x52 | G.h4s6 | D | 316 | G.h4s6.09 |
Hydrophobic | C-term | V | 362 | - | G.H3 | K | 249 | G.H3.07 |
Van-der-waals | C-term | V | 362 | - | G.H3 | K | 249 | G.H3.07 |
Hydrophobic | TM2 | M | 107 | 2x39 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM6 | T | 274 | 6x30 | G.H5 | F | 355 | G.H5.26 |
Polar | C-term | V | 362 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | V | 362 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | V | 362 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | S | 360 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | P | 359 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | P | 359 | - | G.H2 | R | 209 | G.H2.04 |
Polar | C-term | R | 357 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | R | 357 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | TM5 | Q | 258 | 5x71 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | Q | 258 | 5x71 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.H5 | I | 345 | G.H5.16 |
Polar | ICL2 | R | 180 | 34x57 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | ICL2 | R | 180 | 34x57 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | ICL2 | R | 180 | 34x57 | G.HN | R | 24 | G.HN.48 |
Polar | TM6 | K | 276 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM6 | K | 276 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | K | 276 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | ICL2 | A | 173 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | H8 | R | 338 | 8x52 | G.h4s6 | T | 317 | G.h4s6.10 |
Van-der-waals | H8 | R | 338 | 8x52 | G.h4s6 | T | 317 | G.h4s6.10 |
Polar | TM3 | N | 172 | 3x56 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | TM3 | N | 172 | 3x56 | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL3 | Q | 262 | - | G.H5 | D | 342 | G.H5.13 |
Polar | ICL2 | Y | 177 | 34x54 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | ICL2 | Y | 177 | 34x54 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | ICL2 | Y | 177 | 34x54 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM6 | L | 281 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | L | 281 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | L | 174 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 174 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM3 | R | 166 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 166 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | G | 277 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Polar | C-term | F | 354 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | F | 354 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | F | 354 | - | G.H3 | K | 258 | G.H3.16 |
Polar | TM3 | S | 169 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | S | 169 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | S | 169 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM5 | H | 255 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM5 | H | 255 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Polar | ICL2 | A | 173 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | A | 173 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | A | 173 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM5 | V | 252 | 5x65 | G.H5 | F | 355 | G.H5.26 |
Polar | C-term | S | 356 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | S | 356 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | S | 356 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | TM5 | I | 259 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | ICL2 | L | 174 | 34x51 | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | TM5 | V | 252 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM5 | V | 252 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Polar | C-term | P | 353 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | P | 353 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | P | 353 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | P | 359 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | C-term | V | 362 | - | G.H3 | L | 250 | G.H3.08 |
Polar | ICL2 | T | 175 | 34x52 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | T | 175 | 34x52 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | T | 175 | 34x52 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM3 | L | 170 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | L | 170 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | F | 354 | - | G.H3 | N | 256 | G.H3.14 |
Van-der-waals | C-term | F | 354 | - | G.H3 | N | 256 | G.H3.14 |
Polar | ICL3 | Q | 262 | - | G.H5 | A | 339 | G.H5.10 |
Hydrophobic | ICL3 | Q | 262 | - | G.H5 | A | 339 | G.H5.10 |
Van-der-waals | ICL3 | Q | 262 | - | G.H5 | A | 339 | G.H5.10 |
Hydrophobic | TM6 | A | 273 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | A | 273 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | ICL2 | S | 178 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Polar | C-term | S | 358 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | S | 358 | - | G.H3 | S | 253 | G.H3.11 |