Gs - GPR6 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 A 173 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM5 I 259 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 259 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM6 A 273 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM5 V 252 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 252 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM2 M 107 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 M 107 2x39 G.H5 Y 391 G.H5.23
Polar TM5 H 255 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 255 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 255 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM6 T 280 6x36 G.H5 L 393 G.H5.25
Polar C-term S 358 - G.h2s4 D 240 G.h2s4.03
Hydrophobic C-term S 358 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term S 358 - G.h2s4 D 240 G.h2s4.03
Polar TM5 H 255 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 255 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 H 255 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 255 5x68 G.H5 L 388 G.H5.20
Hydrophobic TM2 M 107 2x39 G.H5 Q 390 G.H5.22
Van-der-waals TM2 M 107 2x39 G.H5 Q 390 G.H5.22
Polar TM3 S 169 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 S 169 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 169 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 259 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 259 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 L 281 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 281 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 266 6x22 G.H4 R 347 G.H4.17
Hydrophobic ICL2 R 179 34x56 G.HN Q 35 G.HN.52
Van-der-waals ICL2 R 179 34x56 G.HN Q 35 G.HN.52
Polar ICL3 Q 262 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 Q 262 - G.S6 C 359 G.S6.01
Hydrophobic TM3 L 170 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 170 3x54 G.H5 L 388 G.H5.20
Polar C-term V 362 - G.H5 R 389 G.H5.21
Hydrophobic C-term V 362 - G.H5 R 389 G.H5.21
Van-der-waals C-term V 362 - G.H5 R 389 G.H5.21
Polar ICL2 L 174 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 174 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 174 34x51 G.S1 H 41 G.S1.02
Aromatic ICL2 Y 177 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Y 177 34x54 G.hns1 R 38 G.hns1.02
Polar TM6 T 280 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 280 6x36 G.H5 E 392 G.H5.24
Hydrophobic TM5 A 256 5x69 G.H5 L 394 G.H5.26
Polar TM3 S 169 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 169 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 169 3x53 G.H5 H 387 G.H5.19
Hydrophobic C-term S 360 - G.h3s5 I 285 G.h3s5.03
Van-der-waals C-term S 360 - G.h3s5 I 285 G.h3s5.03
Polar TM6 G 277 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 G 277 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 277 6x33 G.H5 L 393 G.H5.25
Hydrophobic C-term P 359 - G.H5 M 386 G.H5.18
Van-der-waals C-term P 359 - G.H5 M 386 G.H5.18
Hydrophobic C-term P 359 - G.h2s4 D 240 G.h2s4.03
Hydrophobic ICL2 L 174 34x51 G.H5 R 380 G.H5.12
Hydrophobic C-term P 359 - G.h2s4 V 241 G.h2s4.04
Hydrophobic ICL2 S 178 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 I 248 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 266 6x22 G.H4 L 346 G.H4.16
Ionic TM7 R 332 7x56 G.H5 E 392 G.H5.24
Polar TM7 R 332 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 R 332 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 R 332 7x56 G.H5 E 392 G.H5.24
Polar TM6 K 276 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 276 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 276 6x32 G.H5 L 394 G.H5.26
Polar ICL2 Y 177 34x54 G.H5 H 387 G.H5.19
Polar TM5 Q 258 5x71 G.H5 R 385 G.H5.17
Aromatic TM3 R 166 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 Y 391 G.H5.23
Aromatic ICL2 Y 176 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 176 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 174 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 174 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 174 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 174 34x51 G.H5 I 383 G.H5.15
Polar TM3 L 170 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 170 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 170 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 266 6x22 G.h4s6 T 350 G.h4s6.03
Van-der-waals TM6 L 266 6x22 G.h4s6 T 350 G.h4s6.03
Ionic TM5 H 255 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 255 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 255 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 255 5x68 G.H5 D 381 G.H5.13
Polar C-term S 360 - G.h3s5 T 284 G.h3s5.02
Hydrophobic C-term S 360 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term S 360 - G.h3s5 T 284 G.h3s5.02
Hydrophobic TM5 V 252 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 V 252 5x65 G.H5 L 393 G.H5.25
Hydrophobic TM5 V 251 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL2 Y 177 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic TM5 I 259 5x72 G.H5 L 394 G.H5.26
Van-der-waals TM5 I 259 5x72 G.H5 L 394 G.H5.26
Polar ICL3 Q 262 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 A 173 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL2 A 173 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 174 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 T 175 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 174 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 174 34x51 G.H5 F 376 G.H5.08
Hydrophobic TM3 L 170 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM5 H 255 5x68 G.H5 L 394 G.H5.26
Polar ICL3 C 265 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 C 265 - G.hgh4 D 323 G.hgh4.13