GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 69.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 16.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | A | 319 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Polar | C-term | Y | 486 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | C-term | Y | 486 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Van-der-waals | C-term | Y | 486 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | C-term | Y | 482 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | Y | 482 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Polar | TM6 | A | 319 | 6x33 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | A | 319 | 6x33 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM6 | A | 319 | 6x33 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | Y | 482 | - | G.hfs2 | P | 202 | G.hfs2.04 |
Van-der-waals | C-term | Y | 482 | - | G.hfs2 | P | 202 | G.hfs2.04 |
Ionic | C-term | E | 480 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | C-term | E | 480 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | E | 480 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | E | 480 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | Y | 486 | - | H.HD | R | 166 | H.HD.11 |
Van-der-waals | C-term | Y | 486 | - | H.HD | R | 166 | H.HD.11 |
Hydrophobic | C-term | I | 485 | - | H.HA | L | 106 | H.HA.29 |
Van-der-waals | C-term | I | 485 | - | H.HA | L | 106 | H.HA.29 |
Hydrophobic | C-term | S | 484 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | C-term | Y | 483 | - | H.hdhe | L | 170 | H.hdhe.03 |
Hydrophobic | C-term | I | 485 | - | H.HA | A | 102 | H.HA.25 |
Van-der-waals | C-term | I | 485 | - | H.HA | A | 102 | H.HA.25 |
Hydrophobic | ICL3 | A | 308 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | C-term | Y | 483 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | TM7 | R | 378 | 7x55 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | R | 378 | 7x55 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | T | 155 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | T | 155 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | T | 155 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | N | 153 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | N | 153 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | N | 153 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM5 | L | 229 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM3 | V | 147 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM2 | I | 83 | 2x43 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM2 | I | 83 | 2x43 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | C | 323 | 6x37 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | I | 485 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | I | 485 | - | H.HA | K | 105 | H.HA.28 |
Polar | ICL2 | N | 153 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | N | 153 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | N | 153 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL3 | Q | 304 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ICL3 | Q | 304 | - | G.S6 | H | 344 | G.S6.03 |
Polar | ICL2 | Q | 151 | - | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | Q | 151 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM5 | R | 236 | 5x72 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM5 | R | 236 | 5x72 | G.H5 | H | 368 | G.H5.17 |
Ionic | TM5 | R | 236 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Polar | TM5 | R | 236 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | R | 236 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | R | 236 | 5x72 | G.H5 | D | 364 | G.H5.13 |
Polar | TM6 | S | 312 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | S | 312 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | S | 312 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | C-term | Y | 483 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | Y | 483 | - | H.HA | V | 98 | H.HA.21 |
Ionic | ICL3 | D | 245 | - | G.H4 | R | 320 | G.H4.05 |
Polar | ICL3 | D | 245 | - | G.H4 | R | 320 | G.H4.05 |
Hydrophobic | ICL3 | D | 245 | - | G.H4 | R | 320 | G.H4.05 |
Van-der-waals | ICL3 | D | 245 | - | G.H4 | R | 320 | G.H4.05 |
Hydrophobic | TM2 | F | 79 | 2x39 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | I | 485 | - | H.hdhe | F | 168 | H.hdhe.01 |
Van-der-waals | C-term | I | 485 | - | H.hdhe | F | 168 | H.hdhe.01 |
Polar | C-term | Y | 486 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | C-term | Y | 486 | - | H.hdhe | F | 168 | H.hdhe.01 |
Van-der-waals | C-term | Y | 486 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | ICL3 | L | 305 | - | G.S6 | H | 345 | G.S6.04 |
Hydrophobic | TM6 | L | 311 | 6x25 | G.h4s6 | K | 340 | G.h4s6.19 |
Hydrophobic | TM3 | M | 146 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | M | 146 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | Y | 486 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | ICL3 | L | 305 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | ICL3 | L | 305 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ICL3 | L | 305 | - | G.S6 | H | 344 | G.S6.03 |
Polar | C-term | S | 484 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | S | 484 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | S | 484 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | ICL2 | Q | 151 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 151 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | Y | 483 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Van-der-waals | C-term | Y | 483 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | TM2 | F | 79 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | F | 79 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | K | 315 | 6x29 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL3 | Q | 304 | - | G.H4 | V | 327 | G.H4.12 |
Van-der-waals | ICL3 | Q | 304 | - | G.H4 | V | 327 | G.H4.12 |
Polar | C-term | S | 488 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | TM6 | L | 311 | 6x25 | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | ICL3 | V | 244 | - | G.H4 | R | 320 | G.H4.05 |
Hydrophobic | TM3 | V | 147 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Polar | ICL2 | R | 154 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | R | 154 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | R | 154 | - | G.HN | T | 43 | G.HN.52 |
Ionic | TM6 | D | 316 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Polar | ICL3 | Q | 304 | - | G.H4 | E | 328 | G.H4.13 |
Van-der-waals | ICL3 | Q | 304 | - | G.H4 | E | 328 | G.H4.13 |
Hydrophobic | TM5 | L | 229 | 5x65 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | S | 488 | - | H.HA | L | 106 | H.HA.29 |
Polar | C-term | S | 484 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Polar | C-term | P | 481 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | I | 326 | 6x40 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM7 | S | 377 | 7x54 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | S | 377 | 7x54 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | Q | 151 | - | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM5 | I | 225 | 5x61 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM5 | N | 232 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | N | 232 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Polar | ICL3 | Q | 304 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | ICL3 | Q | 304 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | Q | 304 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | TM6 | K | 315 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | K | 315 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM3 | H | 142 | 3x49 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL3 | A | 246 | - | G.S6 | F | 346 | G.S6.05 |
Hydrophobic | TM6 | K | 318 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | K | 318 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM5 | Y | 222 | 5x58 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | V | 147 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Polar | ICL3 | S | 307 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | S | 307 | - | G.H4 | R | 331 | G.H4.16 |
Polar | TM6 | K | 315 | 6x29 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | TM6 | K | 315 | 6x29 | G.h4s6 | Q | 339 | G.h4s6.13 |
Polar | TM3 | M | 146 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | M | 146 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | M | 146 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM7 | Y | 376 | 7x53 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | Y | 376 | 7x53 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | I | 485 | - | H.HD | E | 167 | H.HD.12 |
Van-der-waals | C-term | I | 485 | - | H.HD | E | 167 | H.HD.12 |
Polar | TM6 | T | 322 | 6x36 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | T | 322 | 6x36 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM6 | T | 322 | 6x36 | G.H5 | L | 376 | G.H5.25 |
Polar | C-term | Y | 486 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | C-term | Y | 486 | - | H.HD | E | 167 | H.HD.12 |
Van-der-waals | C-term | Y | 486 | - | H.HD | E | 167 | H.HD.12 |
Polar | C-term | Y | 486 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Hydrophobic | C-term | Y | 486 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Van-der-waals | C-term | Y | 486 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Hydrophobic | C-term | I | 485 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | I | 485 | - | H.HA | D | 101 | H.HA.24 |
Polar | TM7 | R | 378 | 7x55 | G.H5 | Q | 373 | G.H5.22 |
Polar | C-term | Y | 483 | - | H.hdhe | G | 171 | H.hdhe.04 |
Hydrophobic | C-term | Y | 483 | - | H.hdhe | G | 171 | H.hdhe.04 |
Van-der-waals | C-term | Y | 483 | - | H.hdhe | G | 171 | H.hdhe.04 |