GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 69.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | P | 481 | - | G.S2 | F | 195 | G.S2.02 |
Polar | TM4 | P | 159 | 4x40 | G.HN | Q | 33 | G.HN.48 |
Hydrophobic | TM4 | P | 159 | 4x40 | G.HN | Q | 33 | G.HN.48 |
Van-der-waals | TM4 | P | 159 | 4x40 | G.HN | Q | 33 | G.HN.48 |
Polar | ICL3 | L | 303 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL3 | L | 303 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | L | 303 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | E | 379 | G.H5.24 |
Polar | ICL2 | T | 155 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | ICL2 | T | 155 | - | G.HN | L | 37 | G.HN.52 |
Van-der-waals | ICL2 | T | 155 | - | G.HN | L | 37 | G.HN.52 |
Polar | TM5 | N | 232 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | N | 232 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Polar | ICL1 | R | 76 | 12x51 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL1 | R | 76 | 12x51 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL1 | R | 76 | 12x51 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | TM5 | L | 229 | 5x65 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL1 | F | 75 | 12x50 | G.h3s5 | I | 272 | G.h3s5.03 |
Hydrophobic | ICL1 | K | 74 | 12x49 | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | ICL1 | K | 74 | 12x49 | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | TM3 | V | 147 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | ICL3 | S | 247 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL3 | S | 247 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | ICL3 | S | 247 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Ionic | TM5 | R | 236 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | R | 236 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | R | 236 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | R | 236 | 5x72 | G.H5 | D | 368 | G.H5.13 |
Polar | TM6 | K | 315 | 6x29 | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | TM6 | K | 315 | 6x29 | G.S6 | Y | 347 | G.S6.02 |
Ionic | C-term | E | 480 | - | H.HA | K | 78 | H.HA.07 |
Polar | C-term | E | 480 | - | H.HA | K | 78 | H.HA.07 |
Van-der-waals | C-term | E | 480 | - | H.HA | K | 78 | H.HA.07 |
Hydrophobic | C-term | T | 477 | - | G.hfs2 | L | 190 | G.hfs2.04 |
Polar | TM2 | N | 78 | 2x38 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | TM2 | N | 78 | 2x38 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | TM2 | N | 78 | 2x38 | G.hns1 | K | 40 | G.hns1.02 |
Polar | ICL3 | L | 303 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Van-der-waals | ICL3 | L | 303 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Aromatic | TM6 | K | 315 | 6x29 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM6 | K | 315 | 6x29 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM6 | K | 315 | 6x29 | G.h4s6 | Y | 345 | G.h4s6.20 |
Polar | ICL1 | K | 74 | 12x49 | G.h2s4 | N | 226 | G.h2s4.02 |
Hydrophobic | ICL1 | K | 74 | 12x49 | G.h2s4 | N | 226 | G.h2s4.02 |
Van-der-waals | ICL1 | K | 74 | 12x49 | G.h2s4 | N | 226 | G.h2s4.02 |
Hydrophobic | ICL3 | A | 246 | - | G.H4 | F | 326 | G.H4.08 |
Van-der-waals | ICL3 | A | 246 | - | G.H4 | F | 326 | G.H4.08 |
Polar | ICL2 | Q | 151 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | M | 146 | 3x53 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | M | 146 | 3x53 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM2 | N | 78 | 2x38 | G.HN | L | 37 | G.HN.52 |
Van-der-waals | TM2 | N | 78 | 2x38 | G.HN | L | 37 | G.HN.52 |
Polar | ICL2 | Q | 151 | - | G.hns1 | A | 41 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 151 | - | G.hns1 | A | 41 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 151 | - | G.hns1 | A | 41 | G.hns1.03 |
Hydrophobic | ICL3 | I | 242 | - | G.hgh4 | A | 315 | G.hgh4.18 |
Polar | TM6 | S | 312 | 6x26 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM6 | S | 312 | 6x26 | G.H5 | R | 372 | G.H5.17 |
Polar | ICL3 | Q | 304 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL3 | Q | 304 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | Q | 304 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL3 | S | 247 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | S | 247 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | C-term | Y | 482 | - | H.HA | Q | 77 | H.HA.06 |
Van-der-waals | C-term | Y | 482 | - | H.HA | Q | 77 | H.HA.06 |
Van-der-waals | C-term | Y | 483 | - | G.H1 | R | 63 | G.H1.09 |
Polar | TM7 | R | 378 | 7x55 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | TM7 | R | 378 | 7x55 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | TM7 | R | 378 | 7x55 | G.H5 | Q | 377 | G.H5.22 |
Polar | TM2 | T | 77 | 2x37 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | TM2 | T | 77 | 2x37 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | TM2 | T | 77 | 2x37 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL3 | L | 303 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Van-der-waals | ICL3 | L | 303 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Hydrophobic | C-term | Y | 483 | - | G.h1ha | F | 70 | G.h1ha.04 |
Polar | ICL1 | F | 75 | 12x50 | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | ICL1 | F | 75 | 12x50 | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | ICL1 | F | 75 | 12x50 | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | ICL2 | Q | 151 | - | G.s2s3 | K | 203 | G.s2s3.02 |
Polar | ICL3 | Q | 304 | - | G.H4 | D | 330 | G.H4.13 |
Van-der-waals | ICL3 | Q | 304 | - | G.H4 | D | 330 | G.H4.13 |
Polar | ICL3 | A | 246 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL3 | A | 246 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | ICL3 | A | 246 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | C-term | I | 479 | - | G.hfs2 | S | 192 | G.hfs2.06 |
Hydrophobic | ICL1 | F | 75 | 12x50 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | ICL1 | F | 75 | 12x50 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | TM7 | R | 378 | 7x55 | G.H5 | K | 376 | G.H5.21 |
Polar | ICL3 | S | 247 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Hydrophobic | ICL3 | S | 247 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Van-der-waals | ICL3 | S | 247 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Hydrophobic | ICL2 | Q | 151 | - | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | Q | 151 | - | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | ICL3 | A | 246 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | ICL3 | A | 246 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | ICL2 | R | 154 | - | G.HN | L | 37 | G.HN.52 |
Polar | ICL3 | V | 244 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL3 | V | 244 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | ICL3 | V | 244 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL3 | T | 243 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | ICL3 | T | 243 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | TM3 | M | 146 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | M | 146 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM6 | L | 311 | 6x25 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM6 | L | 311 | 6x25 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | TM4 | C | 160 | 4x41 | G.HN | Q | 33 | G.HN.48 |
Polar | TM3 | M | 146 | 3x53 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | M | 146 | 3x53 | G.H5 | Q | 371 | G.H5.16 |
Polar | ICL2 | T | 155 | - | G.hns1 | A | 41 | G.hns1.03 |
Hydrophobic | ICL2 | T | 155 | - | G.hns1 | A | 41 | G.hns1.03 |
Van-der-waals | ICL2 | T | 155 | - | G.hns1 | A | 41 | G.hns1.03 |
Hydrophobic | ICL3 | Q | 304 | - | G.H4 | L | 333 | G.H4.16 |
Van-der-waals | ICL3 | Q | 304 | - | G.H4 | L | 333 | G.H4.16 |
Hydrophobic | C-term | E | 480 | - | G.hfs2 | V | 189 | G.hfs2.03 |
Hydrophobic | TM2 | I | 83 | 2x43 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM2 | I | 83 | 2x43 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL3 | D | 245 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | ICL3 | D | 245 | - | G.hgh4 | T | 312 | G.hgh4.15 |
Polar | ICL3 | D | 245 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Hydrophobic | ICL3 | D | 245 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Van-der-waals | ICL3 | D | 245 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Hydrophobic | TM4 | S | 157 | 4x38 | G.HN | L | 37 | G.HN.52 |
Van-der-waals | TM4 | S | 157 | 4x38 | G.HN | L | 37 | G.HN.52 |
Ionic | C-term | R | 478 | - | H.hbhc | D | 126 | H.hbhc.03 |
Polar | C-term | R | 478 | - | H.hbhc | D | 126 | H.hbhc.03 |
Hydrophobic | C-term | R | 478 | - | H.hbhc | D | 126 | H.hbhc.03 |
Van-der-waals | C-term | R | 478 | - | H.hbhc | D | 126 | H.hbhc.03 |
Hydrophobic | TM6 | A | 319 | 6x33 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | A | 319 | 6x33 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM3 | H | 142 | 3x49 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | D | 245 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Van-der-waals | ICL3 | D | 245 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Ionic | TM5 | R | 236 | 5x72 | G.H5 | D | 365 | G.H5.10 |
Polar | TM5 | R | 236 | 5x72 | G.H5 | D | 365 | G.H5.10 |
Van-der-waals | TM5 | R | 236 | 5x72 | G.H5 | D | 365 | G.H5.10 |
Polar | ICL3 | A | 246 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Hydrophobic | ICL3 | A | 246 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Van-der-waals | ICL3 | A | 246 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Hydrophobic | ICL2 | T | 155 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | TM2 | D | 80 | 2x40 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL3 | A | 246 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Van-der-waals | ICL3 | A | 246 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Hydrophobic | ICL3 | D | 245 | - | G.H4 | T | 322 | G.H4.04 |
Van-der-waals | ICL3 | D | 245 | - | G.H4 | T | 322 | G.H4.04 |
Hydrophobic | TM4 | P | 159 | 4x40 | G.HN | E | 29 | G.HN.44 |
Polar | TM7 | S | 377 | 7x54 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM7 | S | 377 | 7x54 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM7 | S | 377 | 7x54 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL1 | F | 75 | 12x50 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | ICL1 | F | 75 | 12x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | A | 156 | - | G.HN | L | 37 | G.HN.52 |
Van-der-waals | ICL2 | A | 156 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | ICL3 | I | 242 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Van-der-waals | ICL3 | I | 242 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Hydrophobic | ICL3 | I | 242 | - | G.hgh4 | D | 314 | G.hgh4.17 |
Hydrophobic | TM7 | R | 378 | 7x55 | G.H5 | Y | 378 | G.H5.23 |
Polar | ICL3 | Q | 304 | - | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | ICL3 | Q | 304 | - | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | ICL3 | Q | 304 | - | G.H4 | R | 329 | G.H4.12 |
Polar | ICL2 | Q | 151 | - | G.S3 | N | 205 | G.S3.02 |
Van-der-waals | ICL2 | Q | 151 | - | G.S3 | N | 205 | G.S3.02 |
Polar | TM2 | N | 78 | 2x38 | G.HN | R | 36 | G.HN.51 |
Polar | ICL2 | N | 153 | - | G.S3 | N | 205 | G.S3.02 |
Hydrophobic | TM5 | R | 236 | 5x72 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM7 | Y | 376 | 7x53 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM7 | Y | 376 | 7x53 | G.H5 | E | 379 | G.H5.24 |
Polar | ICL3 | T | 243 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Hydrophobic | ICL3 | T | 243 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Van-der-waals | ICL3 | T | 243 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Hydrophobic | TM2 | T | 77 | 2x37 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | T | 77 | 2x37 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL3 | V | 244 | - | G.hgh4 | P | 313 | G.hgh4.16 |
Hydrophobic | C-term | N | 476 | - | H.hbhc | T | 125 | H.hbhc.02 |
Hydrophobic | TM2 | F | 79 | 2x39 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | F | 79 | 2x39 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | Q | 151 | - | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | Q | 151 | - | G.S1 | H | 43 | G.S1.02 |
Polar | TM3 | V | 147 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | V | 147 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Polar | TM4 | S | 157 | 4x38 | G.HN | Q | 33 | G.HN.48 |
Hydrophobic | TM4 | S | 157 | 4x38 | G.HN | Q | 33 | G.HN.48 |
Van-der-waals | TM4 | S | 157 | 4x38 | G.HN | Q | 33 | G.HN.48 |
Hydrophobic | TM3 | M | 146 | 3x53 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | M | 146 | 3x53 | G.H5 | L | 380 | G.H5.25 |
Ionic | TM6 | D | 316 | 6x30 | G.H5 | R | 372 | G.H5.17 |
Polar | TM6 | D | 316 | 6x30 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM6 | D | 316 | 6x30 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM6 | D | 316 | 6x30 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | C-term | Y | 486 | - | G.S2 | R | 198 | G.S2.05 |
Van-der-waals | C-term | Y | 486 | - | G.S2 | R | 198 | G.S2.05 |
Hydrophobic | ICL3 | V | 244 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Van-der-waals | ICL3 | V | 244 | - | G.hgh4 | A | 311 | G.hgh4.14 |
Polar | TM4 | F | 158 | 4x39 | G.HN | Q | 33 | G.HN.48 |
Van-der-waals | TM4 | F | 158 | 4x39 | G.HN | Q | 33 | G.HN.48 |
Aromatic | TM4 | F | 158 | 4x39 | G.HN | R | 36 | G.HN.51 |
Hydrophobic | TM4 | F | 158 | 4x39 | G.HN | R | 36 | G.HN.51 |
Van-der-waals | TM4 | F | 158 | 4x39 | G.HN | R | 36 | G.HN.51 |
Hydrophobic | ICL3 | D | 245 | - | G.hgh4 | V | 307 | G.hgh4.10 |
Van-der-waals | ICL3 | D | 245 | - | G.hgh4 | V | 307 | G.hgh4.10 |
Polar | ICL2 | N | 153 | - | G.S2 | Q | 200 | G.S2.07 |
Hydrophobic | ICL2 | N | 153 | - | G.S2 | Q | 200 | G.S2.07 |
Van-der-waals | ICL2 | N | 153 | - | G.S2 | Q | 200 | G.S2.07 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Ionic | TM7 | R | 378 | 7x55 | G.H5 | E | 379 | G.H5.24 |
Polar | TM7 | R | 378 | 7x55 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM7 | R | 378 | 7x55 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM7 | R | 378 | 7x55 | G.H5 | E | 379 | G.H5.24 |