GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 68.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM2 | T | 77 | 2x37 | G.H5 | L | 393 | G.H5.25 |
Ionic | TM5 | R | 236 | 5x72 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | C-term | Y | 482 | - | H.HA | T | 90 | H.HA.06 |
Hydrophobic | TM6 | L | 311 | 6x25 | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | ICL2 | T | 155 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | ICL1 | R | 76 | 12x51 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL1 | R | 76 | 12x51 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM2 | N | 78 | 2x38 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM2 | N | 78 | 2x38 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM2 | N | 78 | 2x38 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM3 | M | 146 | 3x53 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | V | 306 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Hydrophobic | ICL1 | F | 75 | 12x50 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ICL1 | F | 75 | 12x50 | G.H5 | Q | 390 | G.H5.22 |
Polar | ICL1 | K | 74 | 12x49 | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | ICL1 | K | 74 | 12x49 | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | ICL1 | K | 74 | 12x49 | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | ICL3 | A | 246 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Van-der-waals | ICL3 | A | 246 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Polar | ICL3 | L | 303 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | L | 303 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | L | 303 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | A | 246 | - | G.hgh4 | E | 330 | G.hgh4.20 |
Van-der-waals | ICL3 | A | 246 | - | G.hgh4 | E | 330 | G.hgh4.20 |
Hydrophobic | ICL3 | Q | 304 | - | G.H4 | R | 342 | G.H4.12 |
Van-der-waals | ICL3 | Q | 304 | - | G.H4 | R | 342 | G.H4.12 |
Hydrophobic | ICL3 | A | 246 | - | G.H4 | K | 338 | G.H4.07 |
Van-der-waals | ICL3 | A | 246 | - | G.H4 | K | 338 | G.H4.07 |
Aromatic | TM6 | K | 315 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM6 | K | 315 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | K | 315 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Ionic | TM7 | R | 378 | 7x55 | G.H5 | E | 392 | G.H5.24 |
Polar | TM7 | R | 378 | 7x55 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM7 | R | 378 | 7x55 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | R | 378 | 7x55 | G.H5 | E | 392 | G.H5.24 |
Polar | TM7 | S | 377 | 7x54 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM7 | S | 377 | 7x54 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | S | 377 | 7x54 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM2 | I | 83 | 2x43 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | I | 83 | 2x43 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | V | 244 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Van-der-waals | ICL3 | V | 244 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Ionic | TM5 | R | 236 | 5x72 | G.H5 | D | 378 | G.H5.10 |
Polar | TM5 | R | 236 | 5x72 | G.H5 | D | 378 | G.H5.10 |
Hydrophobic | ICL3 | V | 306 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Polar | TM3 | M | 146 | 3x53 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | M | 146 | 3x53 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL3 | L | 303 | - | G.H4 | R | 342 | G.H4.12 |
Hydrophobic | ICL3 | L | 303 | - | G.H4 | R | 342 | G.H4.12 |
Van-der-waals | ICL3 | L | 303 | - | G.H4 | R | 342 | G.H4.12 |
Polar | TM7 | R | 378 | 7x55 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM7 | R | 378 | 7x55 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM7 | R | 378 | 7x55 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM3 | H | 142 | 3x49 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | Q | 151 | - | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | Q | 151 | - | G.S3 | V | 217 | G.S3.01 |
Polar | ICL3 | A | 246 | - | G.H4 | T | 335 | G.H4.04 |
Hydrophobic | ICL3 | A | 246 | - | G.H4 | T | 335 | G.H4.04 |
Van-der-waals | ICL3 | A | 246 | - | G.H4 | T | 335 | G.H4.04 |
Hydrophobic | TM2 | F | 79 | 2x39 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM2 | F | 79 | 2x39 | G.H5 | L | 393 | G.H5.25 |
Polar | TM7 | R | 378 | 7x55 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM7 | R | 378 | 7x55 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM7 | R | 378 | 7x55 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL3 | D | 245 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Van-der-waals | ICL3 | D | 245 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Polar | ICL3 | D | 245 | - | G.hgh4 | T | 320 | G.hgh4.10 |
Hydrophobic | ICL3 | D | 245 | - | G.hgh4 | T | 320 | G.hgh4.10 |
Van-der-waals | ICL3 | D | 245 | - | G.hgh4 | T | 320 | G.hgh4.10 |
Hydrophobic | ICL1 | F | 75 | 12x50 | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | ICL1 | F | 75 | 12x50 | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | ICL3 | S | 307 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | S | 307 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | S | 307 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | ICL3 | T | 243 | - | G.hgh4 | G | 329 | G.hgh4.19 |
Van-der-waals | ICL3 | T | 243 | - | G.hgh4 | G | 329 | G.hgh4.19 |
Van-der-waals | ICL3 | A | 246 | - | G.hgh4 | E | 327 | G.hgh4.17 |
Polar | TM6 | K | 315 | 6x29 | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | TM6 | K | 315 | 6x29 | G.S6 | Y | 360 | G.S6.02 |
Polar | TM4 | S | 157 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM4 | S | 157 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM4 | S | 157 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | ICL3 | D | 245 | - | G.H4 | P | 332 | G.H4.01 |
Van-der-waals | ICL3 | D | 245 | - | G.H4 | P | 332 | G.H4.01 |
Polar | ICL2 | N | 153 | - | G.s2s3 | K | 216 | G.s2s3.02 |
Hydrophobic | ICL2 | N | 153 | - | G.s2s3 | K | 216 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 153 | - | G.s2s3 | K | 216 | G.s2s3.02 |
Hydrophobic | ICL1 | F | 75 | 12x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL1 | F | 75 | 12x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL3 | Q | 304 | - | G.S6 | F | 363 | G.S6.05 |
Van-der-waals | ICL3 | Q | 304 | - | G.S6 | F | 363 | G.S6.05 |
Ionic | C-term | R | 478 | - | H.hbhc | D | 139 | H.hbhc.03 |
Polar | C-term | R | 478 | - | H.hbhc | D | 139 | H.hbhc.03 |
Hydrophobic | C-term | R | 478 | - | H.hbhc | D | 139 | H.hbhc.03 |
Van-der-waals | C-term | R | 478 | - | H.hbhc | D | 139 | H.hbhc.03 |
Van-der-waals | C-term | I | 479 | - | G.hfs2 | S | 205 | G.hfs2.06 |
Hydrophobic | TM2 | D | 80 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | D | 80 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | S | 247 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Van-der-waals | ICL3 | S | 247 | - | G.hgh4 | A | 324 | G.hgh4.14 |
Polar | ICL3 | T | 243 | - | G.hgh4 | E | 327 | G.hgh4.17 |
Van-der-waals | ICL3 | T | 243 | - | G.hgh4 | E | 327 | G.hgh4.17 |
Hydrophobic | TM2 | D | 80 | 2x40 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | D | 80 | 2x40 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL3 | L | 303 | - | G.hgh4 | E | 322 | G.hgh4.12 |
Polar | ICL3 | Q | 304 | - | G.H4 | Y | 339 | G.H4.08 |
Hydrophobic | ICL3 | Q | 304 | - | G.H4 | Y | 339 | G.H4.08 |
Van-der-waals | ICL3 | Q | 304 | - | G.H4 | Y | 339 | G.H4.08 |
Hydrophobic | ICL3 | I | 242 | - | G.hgh4 | P | 328 | G.hgh4.18 |
Hydrophobic | ICL3 | A | 246 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Van-der-waals | ICL3 | A | 246 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Polar | ICL3 | S | 307 | - | G.H4 | R | 342 | G.H4.12 |
Van-der-waals | ICL3 | S | 307 | - | G.H4 | R | 342 | G.H4.12 |
Polar | ICL3 | S | 247 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Polar | ICL1 | R | 76 | 12x51 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL1 | R | 76 | 12x51 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL1 | R | 76 | 12x51 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL3 | T | 243 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Van-der-waals | ICL3 | T | 243 | - | G.hgh4 | P | 326 | G.hgh4.16 |
Polar | ICL4 | N | 379 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | S | 247 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | S | 247 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | ICL3 | Q | 304 | - | G.H4 | K | 338 | G.H4.07 |
Van-der-waals | ICL3 | Q | 304 | - | G.H4 | K | 338 | G.H4.07 |
Polar | TM4 | F | 158 | 4x39 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM4 | F | 158 | 4x39 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM4 | F | 158 | 4x39 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM7 | Y | 376 | 7x53 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL3 | D | 245 | - | G.H4 | T | 335 | G.H4.04 |
Hydrophobic | ICL3 | D | 245 | - | G.H4 | T | 335 | G.H4.04 |
Van-der-waals | ICL3 | D | 245 | - | G.H4 | T | 335 | G.H4.04 |
Polar | ICL1 | K | 74 | 12x49 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM2 | T | 77 | 2x37 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | T | 77 | 2x37 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM2 | N | 78 | 2x38 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM2 | N | 78 | 2x38 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM2 | N | 78 | 2x38 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Ionic | C-term | E | 480 | - | H.HA | K | 91 | H.HA.07 |
Polar | C-term | E | 480 | - | H.HA | K | 91 | H.HA.07 |
Polar | ICL3 | V | 306 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | V | 306 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | V | 306 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | TM6 | N | 310 | 6x24 | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM3 | M | 146 | 3x53 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | M | 146 | 3x53 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | T | 155 | - | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | T | 155 | - | G.hns1 | A | 39 | G.hns1.03 |
Polar | ICL3 | T | 243 | - | G.hgh4 | P | 328 | G.hgh4.18 |
Van-der-waals | ICL3 | T | 243 | - | G.hgh4 | P | 328 | G.hgh4.18 |
Hydrophobic | C-term | Y | 486 | - | G.h1ha | V | 65 | G.h1ha.01 |
Van-der-waals | C-term | Y | 486 | - | G.h1ha | V | 65 | G.h1ha.01 |
Polar | TM7 | R | 378 | 7x55 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM7 | R | 378 | 7x55 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | TM7 | R | 378 | 7x55 | G.H5 | R | 389 | G.H5.21 |
Ionic | ICL1 | K | 74 | 12x49 | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | ICL1 | K | 74 | 12x49 | G.h2s4 | D | 240 | G.h2s4.03 |
Hydrophobic | ICL1 | K | 74 | 12x49 | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | ICL1 | K | 74 | 12x49 | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | ICL3 | S | 247 | - | G.H4 | Y | 339 | G.H4.08 |
Hydrophobic | ICL3 | S | 247 | - | G.H4 | Y | 339 | G.H4.08 |
Van-der-waals | ICL3 | S | 247 | - | G.H4 | Y | 339 | G.H4.08 |
Ionic | TM6 | D | 316 | 6x30 | G.H5 | R | 385 | G.H5.17 |
Polar | TM6 | D | 316 | 6x30 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | D | 316 | 6x30 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM4 | F | 158 | 4x39 | G.HN | Q | 31 | G.HN.48 |
Van-der-waals | TM4 | F | 158 | 4x39 | G.HN | Q | 31 | G.HN.48 |
Polar | ICL3 | A | 246 | - | G.H4 | Y | 339 | G.H4.08 |
Hydrophobic | ICL3 | A | 246 | - | G.H4 | Y | 339 | G.H4.08 |
Van-der-waals | ICL3 | A | 246 | - | G.H4 | Y | 339 | G.H4.08 |
Polar | ICL3 | S | 247 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | ICL3 | S | 247 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Van-der-waals | ICL3 | S | 247 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | TM2 | I | 83 | 2x43 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | A | 156 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | A | 156 | - | G.HN | Q | 35 | G.HN.52 |
Polar | ICL2 | Q | 151 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | Q | 151 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | Q | 151 | - | G.H5 | Q | 384 | G.H5.16 |
Aromatic | C-term | Y | 483 | - | G.S2 | F | 208 | G.S2.02 |
Hydrophobic | C-term | Y | 483 | - | G.S2 | F | 208 | G.S2.02 |
Van-der-waals | C-term | Y | 483 | - | G.S2 | F | 208 | G.S2.02 |
Polar | TM2 | T | 77 | 2x37 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM2 | T | 77 | 2x37 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM2 | T | 77 | 2x37 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL3 | Q | 304 | - | G.S5 | L | 291 | G.S5.06 |
Van-der-waals | ICL3 | Q | 304 | - | G.S5 | L | 291 | G.S5.06 |
Hydrophobic | ICL3 | L | 305 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Van-der-waals | ICL3 | L | 305 | - | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | ICL3 | S | 247 | - | G.hgh4 | T | 320 | G.hgh4.10 |
Van-der-waals | ICL3 | S | 247 | - | G.hgh4 | T | 320 | G.hgh4.10 |
Hydrophobic | ICL3 | L | 303 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Van-der-waals | ICL3 | L | 303 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Hydrophobic | ICL1 | F | 75 | 12x50 | G.h3s5 | I | 285 | G.h3s5.03 |
Polar | ICL3 | L | 303 | - | G.H4 | Y | 339 | G.H4.08 |
Hydrophobic | ICL3 | L | 303 | - | G.H4 | Y | 339 | G.H4.08 |
Van-der-waals | ICL3 | L | 303 | - | G.H4 | Y | 339 | G.H4.08 |
Hydrophobic | ICL1 | F | 75 | 12x50 | G.h2s4 | V | 241 | G.h2s4.04 |
Hydrophobic | TM4 | P | 159 | 4x40 | G.HN | Q | 31 | G.HN.48 |