GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 70.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | K | 315 | 6x29 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | C-term | Y | 512 | - | H.HA | V | 72 | H.HA.10 |
Hydrophobic | TM7 | R | 378 | 7x55 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | I | 513 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Van-der-waals | C-term | I | 513 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Ionic | C-term | K | 533 | - | H.hbhc | E | 115 | H.hbhc.03 |
Polar | C-term | K | 533 | - | H.hbhc | E | 115 | H.hbhc.03 |
Van-der-waals | C-term | K | 533 | - | H.hbhc | E | 115 | H.hbhc.03 |
Polar | C-term | A | 514 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Van-der-waals | C-term | A | 514 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Hydrophobic | TM2 | F | 79 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | F | 79 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM4 | S | 157 | 4x38 | G.HN | A | 27 | G.HN.51 |
Ionic | TM6 | K | 315 | 6x29 | G.H5 | E | 346 | G.H5.18 |
Polar | TM6 | K | 315 | 6x29 | G.H5 | E | 346 | G.H5.18 |
Ionic | TM7 | R | 378 | 7x55 | G.H5 | D | 350 | G.H5.22 |
Polar | TM7 | R | 378 | 7x55 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM7 | R | 378 | 7x55 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM7 | R | 378 | 7x55 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | C-term | F | 508 | - | H.HB | N | 112 | H.HB.14 |
Van-der-waals | C-term | F | 508 | - | H.HB | N | 112 | H.HB.14 |
Hydrophobic | C-term | I | 513 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Van-der-waals | TM6 | K | 318 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Aromatic | C-term | Y | 483 | - | G.H2 | R | 205 | G.H2.01 |
Polar | C-term | F | 508 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | F | 508 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | C-term | Y | 486 | - | G.H3 | Y | 258 | G.H3.17 |
Van-der-waals | C-term | Y | 486 | - | G.H3 | Y | 258 | G.H3.17 |
Polar | ICL2 | A | 156 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | A | 156 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | A | 156 | - | G.HN | E | 28 | G.HN.52 |
Polar | H8 | R | 384 | 8x51 | G.H5 | F | 354 | G.H5.26 |
Polar | C-term | Y | 512 | - | H.hbhc | G | 117 | H.hbhc.12 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | Y | 486 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | Y | 486 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | Y | 486 | - | G.H3 | H | 256 | G.H3.15 |
Polar | TM6 | T | 322 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 322 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 322 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | I | 225 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | I | 535 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Van-der-waals | C-term | I | 535 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Hydrophobic | ICL1 | F | 75 | 12x50 | G.h2s4 | G | 217 | G.h2s4.03 |
Hydrophobic | ICL2 | Q | 151 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | C-term | S | 511 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | TM3 | V | 147 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | H | 516 | - | G.S2 | I | 185 | G.S2.02 |
Van-der-waals | C-term | H | 516 | - | G.S2 | I | 185 | G.S2.02 |
Ionic | ICL1 | K | 74 | 12x49 | G.h2s4 | E | 216 | G.h2s4.02 |
Polar | ICL1 | K | 74 | 12x49 | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | ICL1 | K | 74 | 12x49 | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | ICL1 | K | 74 | 12x49 | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | ICL1 | F | 72 | - | G.h3s5 | T | 261 | G.h3s5.02 |
Polar | ICL2 | T | 155 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | T | 155 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | T | 155 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | C-term | F | 508 | - | H.HB | Y | 108 | H.HB.10 |
Ionic | ICL2 | R | 154 | - | G.HN | E | 28 | G.HN.52 |
Polar | ICL2 | R | 154 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | R | 154 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | R | 154 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM2 | F | 79 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | Q | 151 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Aromatic | ICL1 | K | 74 | 12x49 | G.H3 | Y | 258 | G.H3.17 |
Polar | C-term | Y | 512 | - | H.hbhc | D | 116 | H.hbhc.04 |
Hydrophobic | C-term | Y | 512 | - | H.hbhc | D | 116 | H.hbhc.04 |
Van-der-waals | C-term | Y | 512 | - | H.hbhc | D | 116 | H.hbhc.04 |
Hydrophobic | C-term | Y | 512 | - | H.HA | A | 71 | H.HA.09 |
Polar | ICL3 | Q | 304 | - | G.S6 | M | 323 | G.S6.05 |
Hydrophobic | ICL3 | Q | 304 | - | G.S6 | M | 323 | G.S6.05 |
Van-der-waals | ICL3 | Q | 304 | - | G.S6 | M | 323 | G.S6.05 |
Hydrophobic | ICL2 | T | 155 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | T | 155 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL1 | K | 74 | 12x49 | G.h2s4 | G | 217 | G.h2s4.03 |
Polar | ICL1 | K | 74 | 12x49 | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | ICL1 | K | 74 | 12x49 | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | TM3 | V | 147 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 147 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | I | 535 | - | H.HA | V | 72 | H.HA.10 |
Van-der-waals | C-term | I | 535 | - | H.HA | V | 72 | H.HA.10 |
Polar | ICL2 | T | 155 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | T | 155 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | C-term | Y | 486 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | H | 516 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Hydrophobic | C-term | V | 540 | - | G.S2 | Q | 188 | G.S2.05 |
Polar | ICL2 | Q | 151 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 151 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 151 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM5 | R | 236 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 236 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 236 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | M | 515 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Van-der-waals | C-term | M | 515 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Polar | C-term | A | 514 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Van-der-waals | C-term | A | 514 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | ICL1 | F | 75 | 12x50 | G.h2s4 | V | 218 | G.h2s4.04 |
Van-der-waals | ICL1 | F | 75 | 12x50 | G.h2s4 | V | 218 | G.h2s4.04 |
Hydrophobic | ICL1 | F | 75 | 12x50 | G.h2s4 | T | 219 | G.h2s4.05 |
Hydrophobic | TM3 | H | 142 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | M | 146 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | V | 540 | - | G.h1ha | K | 58 | G.h1ha.01 |
Van-der-waals | C-term | V | 540 | - | G.h1ha | K | 58 | G.h1ha.01 |
Polar | TM4 | S | 157 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | S | 157 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM6 | A | 319 | 6x33 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | A | 319 | 6x33 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | Y | 512 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Van-der-waals | C-term | Y | 512 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Hydrophobic | C-term | A | 514 | - | G.S2 | I | 185 | G.S2.02 |
Hydrophobic | TM5 | Y | 222 | 5x58 | G.H5 | L | 353 | G.H5.25 |
Polar | H8 | S | 380 | 8x47 | G.H5 | F | 354 | G.H5.26 |
Polar | TM4 | S | 157 | 4x38 | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | TM4 | S | 157 | 4x38 | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | TM4 | S | 157 | 4x38 | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | TM3 | M | 146 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | P | 536 | - | H.HA | E | 68 | H.HA.06 |
Van-der-waals | C-term | P | 536 | - | H.HA | E | 68 | H.HA.06 |
Hydrophobic | C-term | I | 485 | - | G.H3 | I | 253 | G.H3.12 |
Polar | C-term | Y | 512 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | C-term | Y | 512 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Van-der-waals | C-term | Y | 512 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Polar | ICL2 | P | 152 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | P | 152 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | P | 152 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | N | 153 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | N | 153 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | N | 153 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | C-term | N | 510 | - | H.hbhc | D | 116 | H.hbhc.04 |
Van-der-waals | C-term | N | 510 | - | H.hbhc | D | 116 | H.hbhc.04 |
Hydrophobic | TM6 | K | 315 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 315 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Polar | TM6 | S | 312 | 6x26 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | S | 312 | 6x26 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | L | 311 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | L | 311 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM2 | F | 79 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | F | 79 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Ionic | H8 | R | 385 | 8x52 | G.h4s6 | D | 316 | G.h4s6.10 |
Polar | H8 | R | 385 | 8x52 | G.h4s6 | D | 316 | G.h4s6.10 |
Hydrophobic | H8 | R | 385 | 8x52 | G.h4s6 | D | 316 | G.h4s6.10 |
Van-der-waals | H8 | R | 385 | 8x52 | G.h4s6 | D | 316 | G.h4s6.10 |
Hydrophobic | C-term | A | 514 | - | G.hfs2 | T | 181 | G.hfs2.05 |
Ionic | ICL2 | R | 154 | - | G.HN | E | 25 | G.HN.49 |
Polar | ICL2 | R | 154 | - | G.HN | E | 25 | G.HN.49 |
Hydrophobic | ICL2 | R | 154 | - | G.HN | E | 25 | G.HN.49 |
Van-der-waals | ICL2 | R | 154 | - | G.HN | E | 25 | G.HN.49 |
Hydrophobic | C-term | Y | 512 | - | H.HA | S | 75 | H.HA.13 |
Van-der-waals | C-term | Y | 512 | - | H.HA | S | 75 | H.HA.13 |
Hydrophobic | C-term | F | 508 | - | H.HB | A | 111 | H.HB.13 |
Hydrophobic | TM6 | K | 315 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | K | 315 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | C-term | I | 513 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Van-der-waals | C-term | I | 513 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Polar | C-term | H | 516 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | H | 516 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | H | 516 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | P | 538 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | ICL3 | L | 305 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | ICL3 | L | 305 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | C-term | Y | 486 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | TM7 | I | 375 | 7x52 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM7 | Y | 376 | 7x53 | G.H5 | G | 352 | G.H5.24 |
Polar | TM6 | K | 315 | 6x29 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM6 | K | 315 | 6x29 | G.S6 | Y | 320 | G.S6.02 |
Ionic | TM6 | D | 316 | 6x30 | G.H5 | K | 345 | G.H5.17 |
Polar | TM6 | D | 316 | 6x30 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | D | 316 | 6x30 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | D | 316 | 6x30 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM3 | M | 146 | 3x53 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | M | 146 | 3x53 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | F | 508 | - | H.HA | L | 82 | H.HA.20 |
Hydrophobic | TM7 | S | 377 | 7x54 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | I | 485 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | I | 485 | - | G.H3 | S | 252 | G.H3.11 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | A | 514 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Ionic | TM6 | K | 315 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 315 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | K | 315 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 315 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | C | 323 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | C | 323 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Ionic | H8 | R | 385 | 8x52 | G.h4s6 | E | 315 | G.h4s6.09 |
Polar | H8 | R | 385 | 8x52 | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | H8 | R | 385 | 8x52 | G.h4s6 | E | 315 | G.h4s6.09 |