GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | H | 202 | 5x68 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | H | 202 | 5x68 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | L | 359 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | C-term | T | 353 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | T | 353 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | C-term | R | 339 | - | G.H2 | R | 227 | G.H2.01 |
Hydrophobic | C-term | Q | 360 | - | G.s4h3 | Q | 254 | G.s4h3.06 |
Van-der-waals | C-term | Q | 360 | - | G.s4h3 | Q | 254 | G.s4h3.06 |
Polar | TM2 | R | 39 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM2 | R | 39 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | R | 39 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Polar | ICL2 | R | 117 | 34x56 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | R | 117 | 34x56 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | R | 117 | 34x56 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM6 | A | 239 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | A | 239 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM5 | V | 198 | 5x64 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | L | 337 | - | G.H2 | R | 227 | G.H2.01 |
Van-der-waals | C-term | L | 337 | - | G.H2 | R | 227 | G.H2.01 |
Hydrophobic | C-term | V | 329 | - | G.H2 | F | 234 | G.H2.08 |
Van-der-waals | C-term | V | 329 | - | G.H2 | F | 234 | G.H2.08 |
Polar | C-term | Q | 360 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | C-term | Q | 360 | - | H.hdhe | F | 168 | H.hdhe.01 |
Van-der-waals | C-term | Q | 360 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | ICL2 | L | 112 | 34x51 | G.H5 | V | 362 | G.H5.11 |
Hydrophobic | TM5 | H | 202 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | H | 202 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | T | 353 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | T | 353 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Hydrophobic | C-term | L | 336 | - | G.H3 | T | 274 | G.H3.11 |
Polar | C-term | N | 355 | - | H.HB | T | 127 | H.HB.14 |
Hydrophobic | C-term | N | 355 | - | H.HB | T | 127 | H.HB.14 |
Van-der-waals | C-term | N | 355 | - | H.HB | T | 127 | H.HB.14 |
Hydrophobic | C-term | N | 355 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | C-term | T | 340 | - | G.H2 | R | 227 | G.H2.01 |
Van-der-waals | C-term | T | 340 | - | G.H2 | R | 227 | G.H2.01 |
Hydrophobic | TM7 | L | 297 | 7x56 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | L | 297 | 7x56 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | P | 111 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | P | 111 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Polar | TM6 | K | 242 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | K | 242 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | K | 242 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Polar | C-term | Q | 360 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | C-term | Q | 360 | - | H.HD | E | 167 | H.HD.12 |
Van-der-waals | C-term | Q | 360 | - | H.HD | E | 167 | H.HD.12 |
Ionic | C-term | E | 354 | - | H.HA | K | 94 | H.HA.17 |
Polar | C-term | E | 354 | - | H.HA | K | 94 | H.HA.17 |
Van-der-waals | C-term | E | 354 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | ICL2 | A | 115 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | A | 115 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | C-term | L | 359 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | L | 359 | - | H.HA | K | 105 | H.HA.28 |
Polar | C-term | Q | 335 | - | G.H3 | T | 274 | G.H3.11 |
Hydrophobic | C-term | Q | 335 | - | G.H3 | T | 274 | G.H3.11 |
Hydrophobic | TM5 | A | 199 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | A | 199 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | L | 112 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | L | 112 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL2 | P | 111 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Polar | ICL2 | R | 117 | 34x56 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ICL2 | R | 117 | 34x56 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | ICL2 | R | 117 | 34x56 | G.HN | K | 42 | G.HN.51 |
Polar | TM2 | T | 38 | 2x36 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM5 | H | 202 | 5x68 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM5 | H | 202 | 5x68 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM5 | H | 202 | 5x68 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ICL2 | A | 115 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Polar | C-term | R | 339 | - | G.H3 | N | 270 | G.H3.07 |
Hydrophobic | C-term | R | 339 | - | G.H3 | N | 270 | G.H3.07 |
Van-der-waals | C-term | R | 339 | - | G.H3 | N | 270 | G.H3.07 |
Polar | ICL2 | R | 117 | 34x56 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | R | 117 | 34x56 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | R | 117 | 34x56 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | L | 112 | 34x51 | G.S3 | F | 218 | G.S3.03 |
Ionic | C-term | R | 339 | - | G.H3 | E | 273 | G.H3.10 |
Polar | C-term | R | 339 | - | G.H3 | E | 273 | G.H3.10 |
Van-der-waals | C-term | R | 339 | - | G.H3 | E | 273 | G.H3.10 |
Polar | C-term | Q | 360 | - | H.HD | R | 166 | H.HD.11 |
Hydrophobic | C-term | Q | 360 | - | H.HD | R | 166 | H.HD.11 |
Van-der-waals | C-term | Q | 360 | - | H.HD | R | 166 | H.HD.11 |
Polar | C-term | S | 357 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | C-term | S | 357 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | S | 357 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | ICL2 | L | 112 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | L | 112 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | C-term | M | 332 | - | G.H3 | F | 281 | G.H3.18 |
Ionic | TM5 | R | 205 | 5x71 | G.H5 | D | 364 | G.H5.13 |
Ionic | C-term | D | 328 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | D | 328 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | D | 328 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | TM5 | M | 206 | 5x72 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | C-term | V | 333 | - | G.H2 | F | 234 | G.H2.08 |
Van-der-waals | C-term | L | 359 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | ICL2 | G | 116 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | G | 116 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | V | 329 | - | G.H3 | V | 280 | G.H3.17 |
Van-der-waals | C-term | V | 329 | - | G.H3 | V | 280 | G.H3.17 |
Hydrophobic | TM5 | M | 206 | 5x72 | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | TM5 | M | 206 | 5x72 | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | TM6 | K | 242 | 6x36 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | K | 242 | 6x36 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM6 | K | 242 | 6x36 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | V | 108 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Polar | ICL3 | A | 213 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | ICL3 | A | 213 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | A | 213 | - | G.H4 | R | 331 | G.H4.16 |
Polar | TM6 | R | 235 | 6x29 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | R | 235 | 6x29 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | R | 235 | 6x29 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | V | 108 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | V | 108 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM5 | T | 210 | 5x76 | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | C-term | L | 337 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | C-term | M | 332 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Van-der-waals | C-term | M | 332 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Polar | ICL2 | R | 117 | 34x56 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | R | 117 | 34x56 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | S | 357 | - | H.hdhe | F | 168 | H.hdhe.01 |
Van-der-waals | C-term | S | 357 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | TM5 | A | 199 | 5x65 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | C | 358 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | ICL2 | L | 112 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Polar | C-term | S | 357 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | S | 357 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | S | 357 | - | H.HA | D | 101 | H.HA.24 |
Polar | C-term | C | 358 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | C | 358 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | C | 358 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | M | 332 | - | G.H3 | I | 275 | G.H3.12 |
Hydrophobic | C-term | L | 359 | - | H.HA | L | 106 | H.HA.29 |
Van-der-waals | C-term | L | 359 | - | H.HA | L | 106 | H.HA.29 |
Hydrophobic | TM5 | M | 206 | 5x72 | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | TM5 | M | 206 | 5x72 | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | C-term | Q | 360 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | C-term | L | 336 | - | G.H2 | W | 233 | G.H2.07 |
Hydrophobic | TM3 | V | 108 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | V | 108 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | H8 | R | 298 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | R | 298 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | E | 354 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | E | 354 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Ionic | C-term | D | 352 | - | H.hbhc | R | 128 | H.hbhc.01 |
Polar | C-term | D | 352 | - | H.hbhc | R | 128 | H.hbhc.01 |
Van-der-waals | C-term | D | 352 | - | H.hbhc | R | 128 | H.hbhc.01 |
Hydrophobic | C-term | E | 354 | - | G.hfs2 | P | 202 | G.hfs2.04 |
Van-der-waals | C-term | E | 354 | - | G.hfs2 | P | 202 | G.hfs2.04 |
Polar | TM3 | A | 107 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | A | 107 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | A | 107 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM4 | R | 119 | 4x38 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM4 | R | 119 | 4x38 | G.hns1 | R | 47 | G.hns1.03 |
Polar | C-term | D | 328 | - | G.H3 | N | 278 | G.H3.15 |
Van-der-waals | C-term | D | 328 | - | G.H3 | N | 278 | G.H3.15 |
Hydrophobic | ICL2 | G | 116 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | G | 116 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL3 | L | 216 | - | G.H4 | K | 324 | G.H4.09 |
Van-der-waals | ICL3 | L | 216 | - | G.H4 | K | 324 | G.H4.09 |
Hydrophobic | C-term | L | 336 | - | G.H3 | I | 271 | G.H3.08 |
Hydrophobic | C-term | M | 332 | - | G.H3 | T | 274 | G.H3.11 |
Van-der-waals | C-term | M | 332 | - | G.H3 | T | 274 | G.H3.11 |
Hydrophobic | ICL2 | R | 113 | 34x52 | G.S3 | V | 216 | G.S3.01 |
Polar | C-term | Q | 360 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Hydrophobic | C-term | Q | 360 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Van-der-waals | C-term | Q | 360 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Hydrophobic | ICL2 | L | 112 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | C-term | M | 332 | - | G.H3 | N | 278 | G.H3.15 |
Van-der-waals | C-term | M | 332 | - | G.H3 | N | 278 | G.H3.15 |
Polar | C-term | S | 357 | - | H.HA | A | 102 | H.HA.25 |
Hydrophobic | C-term | S | 357 | - | H.HA | A | 102 | H.HA.25 |
Van-der-waals | C-term | S | 357 | - | H.HA | A | 102 | H.HA.25 |
Ionic | TM5 | H | 202 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Polar | TM5 | H | 202 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | H | 202 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | H | 202 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ICL2 | L | 112 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | C-term | L | 336 | - | G.H3 | I | 275 | G.H3.12 |
Hydrophobic | C-term | D | 356 | - | H.HA | V | 98 | H.HA.21 |
Polar | C-term | N | 355 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | C-term | N | 355 | - | H.HA | K | 94 | H.HA.17 |
Van-der-waals | C-term | N | 355 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | TM5 | V | 209 | 5x75 | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | TM3 | Q | 104 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | Q | 104 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | V | 333 | - | G.H2 | K | 231 | G.H2.05 |
Polar | C-term | L | 336 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | C-term | L | 336 | - | G.H2 | R | 230 | G.H2.04 |
Polar | H8 | R | 299 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | R | 299 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | R | 299 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | P | 111 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | P | 111 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Polar | TM6 | R | 235 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Polar | ICL2 | R | 117 | 34x56 | G.HN | S | 39 | G.HN.48 |