G12 - GPR82 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 78.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 147 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 147 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 147 34x57 G.hns1 R 55 G.hns1.02
Polar ICL2 Y 139 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 T 235 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 T 235 - G.H5 H 364 G.H5.09
Polar H8 T 315 8x49 G.H5 L 380 G.H5.25
Polar TM6 I 237 6x23 G.H5 H 364 G.H5.09
Hydrophobic TM6 I 237 6x23 G.H5 H 364 G.H5.09
Van-der-waals TM6 I 237 6x23 G.H5 H 364 G.H5.09
Hydrophobic TM6 V 247 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 247 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM3 L 121 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 121 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 K 124 - G.H5 L 371 G.H5.16
Polar ICL2 S 127 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 127 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 127 - G.hns1 R 56 G.hns1.03
Hydrophobic TM6 I 237 6x23 G.H5 D 368 G.H5.13
Van-der-waals TM6 I 237 6x23 G.H5 D 368 G.H5.13
Polar TM3 R 117 3x50 G.H5 Q 381 G.H5.26
Van-der-waals TM3 R 117 3x50 G.H5 Q 381 G.H5.26
Hydrophobic TM5 F 224 5x61 G.H5 I 378 G.H5.23
Hydrophobic TM5 I 231 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 I 231 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM6 L 251 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 251 6x37 G.H5 M 379 G.H5.24
Hydrophobic H8 D 313 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 D 313 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 Q 128 - G.s2s3 K 219 G.s2s3.01
Hydrophobic TM3 T 120 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 T 120 3x53 G.H5 I 378 G.H5.23
Polar ICL2 K 136 - G.HN R 52 G.HN.52
Hydrophobic ICL2 K 136 - G.HN R 52 G.HN.52
Van-der-waals ICL2 K 136 - G.HN R 52 G.HN.52
Ionic ICL2 E 129 - G.s2s3 K 220 G.s2s3.02
Polar ICL2 E 129 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 E 129 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 E 129 - G.s2s3 K 220 G.s2s3.02
Polar TM6 T 243 6x29 G.H5 K 376 G.H5.21
Hydrophobic TM6 T 243 6x29 G.H5 K 376 G.H5.21
Van-der-waals TM6 T 243 6x29 G.H5 K 376 G.H5.21
Polar ICL2 K 144 34x54 G.HN R 51 G.HN.51
Hydrophobic ICL2 K 144 34x54 G.HN R 51 G.HN.51
Van-der-waals ICL2 K 144 34x54 G.HN R 51 G.HN.51
Hydrophobic TM5 L 228 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 228 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM7 L 312 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 312 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM3 L 121 3x54 G.H5 I 378 G.H5.23
Polar ICL2 G 140 34x50 G.HN R 52 G.HN.52
Hydrophobic ICL2 G 140 34x50 G.HN R 52 G.HN.52
Van-der-waals ICL2 G 140 34x50 G.HN R 52 G.HN.52
Hydrophobic TM6 H 250 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 H 250 6x36 G.H5 M 379 G.H5.24
Polar TM2 T 48 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM2 T 48 2x37 G.H5 Q 381 G.H5.26
Van-der-waals TM2 T 48 2x37 G.H5 Q 381 G.H5.26
Polar ICL2 K 144 34x54 G.HN R 52 G.HN.52
Hydrophobic ICL2 K 144 34x54 G.HN R 52 G.HN.52
Van-der-waals ICL2 K 144 34x54 G.HN R 52 G.HN.52
Hydrophobic TM5 F 224 5x61 G.H5 L 375 G.H5.20
Van-der-waals TM5 F 224 5x61 G.H5 L 375 G.H5.20
Hydrophobic ICL3 T 235 - G.H5 K 367 G.H5.12
Polar ICL3 S 236 - G.H5 H 364 G.H5.09
Hydrophobic ICL3 S 236 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 S 236 - G.H5 H 364 G.H5.09
Polar TM6 T 243 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM6 T 243 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 T 243 6x29 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 K 124 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 K 124 - G.H5 N 374 G.H5.19
Polar ICL2 Q 128 - G.S2 V 217 G.S2.07
Hydrophobic ICL2 Q 128 - G.S2 V 217 G.S2.07
Van-der-waals ICL2 Q 128 - G.S2 V 217 G.S2.07
Polar ICL3 C 234 - G.s2s3 K 219 G.s2s3.01
Hydrophobic ICL3 C 234 - G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL3 C 234 - G.s2s3 K 219 G.s2s3.01
Polar TM3 R 117 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 117 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 117 3x50 G.H5 I 378 G.H5.23
Polar ICL2 K 124 - G.S3 I 221 G.S3.01
Hydrophobic ICL2 K 124 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 K 124 - G.S3 I 221 G.S3.01
Hydrophobic ICL2 D 125 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 D 125 - G.s2s3 K 220 G.s2s3.02
Polar ICL2 S 127 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 S 127 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 S 127 - G.s2s3 K 220 G.s2s3.02
Polar ICL2 K 144 34x54 G.HN A 53 G.HN.53
Polar ICL2 I 137 - G.HN R 52 G.HN.52
Van-der-waals ICL2 I 137 - G.HN R 52 G.HN.52
Polar ICL2 S 126 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 126 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 126 - G.hns1 R 56 G.hns1.03
Hydrophobic TM2 H 51 2x40 G.H5 Q 381 G.H5.26
Polar ICL2 H 141 34x51 G.HN R 52 G.HN.52
Aromatic ICL2 H 141 34x51 G.HN R 52 G.HN.52
Hydrophobic ICL2 H 141 34x51 G.HN R 52 G.HN.52
Van-der-waals ICL2 H 141 34x51 G.HN R 52 G.HN.52
Hydrophobic TM4 Q 148 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 Q 148 4x38 G.hns1 R 55 G.hns1.02
Polar TM3 Q 123 3x56 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 Q 123 3x56 G.hns1 R 56 G.hns1.03
Van-der-waals TM3 Q 123 3x56 G.hns1 R 56 G.hns1.03
Polar TM3 R 117 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM3 R 117 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 R 117 3x50 G.H5 M 379 G.H5.24
Hydrophobic H8 K 314 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 K 314 8x48 G.H5 L 380 G.H5.25
Van-der-waals ICL2 K 144 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 D 125 - G.S3 I 221 G.S3.01
Hydrophobic TM2 L 54 2x43 G.H5 Q 381 G.H5.26
Van-der-waals TM2 L 54 2x43 G.H5 Q 381 G.H5.26
Polar TM2 T 50 2x39 G.H5 Q 381 G.H5.26
Hydrophobic TM2 T 50 2x39 G.H5 Q 381 G.H5.26
Van-der-waals TM2 T 50 2x39 G.H5 Q 381 G.H5.26
Polar ICL1 K 46 - G.h3s5 N 288 G.h3s5.02
Van-der-waals ICL1 K 46 - G.h3s5 N 288 G.h3s5.02
Hydrophobic ICL2 S 127 - G.S3 P 222 G.S3.02
Van-der-waals ICL2 S 127 - G.S3 P 222 G.S3.02
Polar ICL2 K 144 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 K 144 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 144 34x54 G.hns1 R 55 G.hns1.02
Polar H8 K 318 8x52 G.h4s6 S 343 G.h4s6.12
Polar ICL3 T 235 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 T 235 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 T 235 - G.H5 D 368 G.H5.13
Polar ICL2 Q 128 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 Q 128 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 Q 128 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 H 141 34x51 G.HN A 48 G.HN.48
Polar TM3 M 122 3x55 G.hns1 R 56 G.hns1.03