G15 - GPR82 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 121 3x54 G.H5 Y 367 G.H5.19
Hydrophobic TM6 H 250 6x36 G.H5 L 374 G.H5.26
Polar TM6 I 237 6x23 G.H5 D 361 G.H5.13
Hydrophobic TM6 I 237 6x23 G.H5 D 361 G.H5.13
Van-der-waals TM6 I 237 6x23 G.H5 D 361 G.H5.13
Hydrophobic TM6 M 238 6x24 G.H5 L 364 G.H5.16
Polar TM6 V 247 6x33 G.H5 N 372 G.H5.24
Hydrophobic TM6 V 247 6x33 G.H5 N 372 G.H5.24
Van-der-waals TM6 V 247 6x33 G.H5 N 372 G.H5.24
Hydrophobic ICL2 K 144 34x54 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 K 144 34x54 G.hns1 G 41 G.hns1.03
Hydrophobic TM2 L 54 2x43 G.H5 L 374 G.H5.26
Van-der-waals TM2 L 54 2x43 G.H5 L 374 G.H5.26
Hydrophobic TM5 F 224 5x61 G.H5 L 368 G.H5.20
Hydrophobic TM6 V 247 6x33 G.H5 I 371 G.H5.23
Hydrophobic TM5 I 231 5x68 G.H5 L 364 G.H5.16
Van-der-waals TM5 I 231 5x68 G.H5 L 364 G.H5.16
Polar TM6 T 243 6x29 G.H5 D 369 G.H5.21
Hydrophobic TM6 T 243 6x29 G.H5 D 369 G.H5.21
Van-der-waals TM6 T 243 6x29 G.H5 D 369 G.H5.21
Hydrophobic H8 T 315 8x49 G.H5 L 373 G.H5.25
Van-der-waals H8 T 315 8x49 G.H5 L 373 G.H5.25
Polar TM3 R 117 3x50 G.H5 Y 367 G.H5.19
Van-der-waals TM3 R 117 3x50 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 K 124 - G.H5 L 364 G.H5.16
Van-der-waals ICL2 K 124 - G.H5 L 364 G.H5.16
Polar TM3 R 117 3x50 G.H5 L 374 G.H5.26
Hydrophobic TM3 R 117 3x50 G.H5 L 374 G.H5.26
Van-der-waals TM3 R 117 3x50 G.H5 L 374 G.H5.26
Hydrophobic TM6 V 247 6x33 G.H5 L 368 G.H5.20
Van-der-waals TM6 V 247 6x33 G.H5 L 368 G.H5.20
Hydrophobic ICL2 K 124 - G.H5 Y 367 G.H5.19
Van-der-waals ICL2 K 124 - G.H5 Y 367 G.H5.19
Hydrophobic TM6 I 237 6x23 G.S6 F 340 G.S6.02
Polar TM4 Q 148 4x38 G.hns1 R 40 G.hns1.02
Hydrophobic TM4 Q 148 4x38 G.hns1 R 40 G.hns1.02
Van-der-waals TM4 Q 148 4x38 G.hns1 R 40 G.hns1.02
Hydrophobic TM6 M 238 6x24 G.H5 L 368 G.H5.20
Polar TM6 T 243 6x29 G.h4s6 R 335 G.h4s6.17
Polar TM6 L 242 6x28 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM6 L 242 6x28 G.h4s6 R 335 G.h4s6.17
Van-der-waals TM6 L 242 6x28 G.h4s6 R 335 G.h4s6.17
Polar TM6 S 246 6x32 G.H5 N 372 G.H5.24
Hydrophobic TM6 S 246 6x32 G.H5 N 372 G.H5.24
Van-der-waals TM6 S 246 6x32 G.H5 N 372 G.H5.24
Hydrophobic TM3 T 120 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 T 120 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM3 L 121 3x54 G.H5 L 364 G.H5.16
Van-der-waals TM3 L 121 3x54 G.H5 L 364 G.H5.16
Hydrophobic TM5 L 228 5x65 G.H5 L 368 G.H5.20
Van-der-waals TM5 L 228 5x65 G.H5 L 368 G.H5.20
Polar ICL3 S 236 - G.H5 K 357 G.H5.09
Hydrophobic TM5 L 228 5x65 G.H5 L 364 G.H5.16
Ionic ICL2 D 125 - G.H5 R 360 G.H5.12
Polar ICL2 D 125 - G.H5 R 360 G.H5.12
Polar ICL2 K 136 - G.s2s3 K 201 G.s2s3.02
Hydrophobic ICL2 K 136 - G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 K 136 - G.s2s3 K 201 G.s2s3.02
Hydrophobic TM2 T 48 2x37 G.H5 E 370 G.H5.22
Van-der-waals TM2 T 48 2x37 G.H5 E 370 G.H5.22
Hydrophobic TM2 T 50 2x39 G.H5 L 374 G.H5.26
Van-der-waals TM2 T 50 2x39 G.H5 L 374 G.H5.26
Polar TM6 I 237 6x23 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM6 I 237 6x23 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 I 237 6x23 G.h4s6 R 338 G.h4s6.20
Hydrophobic H8 K 314 8x48 G.h4s6 R 335 G.h4s6.17
Van-der-waals H8 K 314 8x48 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM2 H 51 2x40 G.H5 L 373 G.H5.25
Polar ICL3 S 236 - G.H5 D 361 G.H5.13
Hydrophobic TM5 F 224 5x61 G.H5 Y 367 G.H5.19
Polar TM6 H 250 6x36 G.H5 N 372 G.H5.24
Hydrophobic TM6 H 250 6x36 G.H5 N 372 G.H5.24
Van-der-waals TM6 H 250 6x36 G.H5 N 372 G.H5.24
Hydrophobic TM5 F 224 5x61 G.H5 I 371 G.H5.23
Van-der-waals TM5 F 224 5x61 G.H5 I 371 G.H5.23
Hydrophobic ICL3 T 235 - G.H5 R 360 G.H5.12
Van-der-waals ICL3 T 235 - G.H5 R 360 G.H5.12
Hydrophobic ICL3 T 235 - G.H5 D 361 G.H5.13
Van-der-waals ICL3 T 235 - G.H5 D 361 G.H5.13
Polar ICL2 K 124 - G.H5 V 363 G.H5.15
Hydrophobic ICL2 K 124 - G.H5 V 363 G.H5.15
Van-der-waals ICL2 K 124 - G.H5 V 363 G.H5.15
Hydrophobic TM6 T 243 6x29 G.H5 L 368 G.H5.20
Polar ICL2 Q 128 - G.H5 R 360 G.H5.12
Hydrophobic ICL2 Q 128 - G.H5 R 360 G.H5.12
Van-der-waals ICL2 Q 128 - G.H5 R 360 G.H5.12
Hydrophobic TM6 I 254 6x40 G.H5 L 374 G.H5.26
Van-der-waals TM6 I 254 6x40 G.H5 L 374 G.H5.26
Aromatic ICL2 R 147 34x57 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 R 147 34x57 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 R 147 34x57 G.H5 Y 367 G.H5.19
Hydrophobic TM6 I 237 6x23 G.H5 S 362 G.H5.14
Polar TM3 R 117 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM3 R 117 3x50 G.H5 I 371 G.H5.23
Van-der-waals TM3 R 117 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM6 I 237 6x23 G.H5 A 365 G.H5.17
Van-der-waals ICL2 S 127 - G.s2s3 Q 200 G.s2s3.01
Hydrophobic H8 D 313 8x47 G.H5 L 373 G.H5.25
Van-der-waals H8 D 313 8x47 G.H5 L 373 G.H5.25
Polar ICL2 K 144 34x54 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 K 144 34x54 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 K 144 34x54 G.hns1 R 40 G.hns1.02
Hydrophobic TM3 I 113 3x46 G.H5 L 374 G.H5.26
Ionic TM6 D 241 6x27 G.h4s6 R 338 G.h4s6.20
Polar TM6 D 241 6x27 G.h4s6 R 338 G.h4s6.20
Hydrophobic TM6 D 241 6x27 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 D 241 6x27 G.h4s6 R 338 G.h4s6.20
Polar ICL2 K 136 - G.s2s3 Q 200 G.s2s3.01
Polar ICL3 C 234 - G.H5 R 360 G.H5.12