G12 - GPR83 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 T 290 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 T 290 6x33 G.H5 Q 381 G.H5.26
Hydrophobic TM7 Y 345 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 345 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM4 I 183 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 I 183 4x39 G.HN R 52 G.HN.52
Hydrophobic TM6 L 294 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM6 Q 279 6x22 G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 P 176 - G.H5 L 371 G.H5.16
Hydrophobic ICL1 M 102 12x50 G.H5 L 380 G.H5.25
Polar ICL2 R 180 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 R 180 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 180 - G.H5 N 374 G.H5.19
Van-der-waals TM6 Q 279 6x22 G.h4s6 R 339 G.h4s6.08
Hydrophobic TM6 T 290 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM6 M 293 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 M 293 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM5 I 272 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 I 272 5x71 G.H5 H 364 G.H5.09
Hydrophobic ICL3 V 275 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 L 283 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 L 283 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM5 I 272 5x71 G.H5 D 368 G.H5.13
Van-der-waals TM5 I 272 5x71 G.H5 D 368 G.H5.13
Polar TM6 Q 279 6x22 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM6 Q 279 6x22 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 Q 279 6x22 G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL2 P 179 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 179 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 176 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 176 - G.H5 K 367 G.H5.12
Hydrophobic TM5 K 265 5x64 G.H5 L 371 G.H5.16
Polar TM6 Q 279 6x22 G.S6 L 346 G.S6.01
Ionic ICL2 R 180 - G.H5 D 377 G.H5.22
Polar ICL2 R 180 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 R 180 - G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 180 - G.H5 D 377 G.H5.22
Hydrophobic TM5 I 272 5x71 G.H5 A 365 G.H5.10
Hydrophobic TM5 G 273 5x72 G.H5 F 361 G.H5.06
Polar ICL1 H 103 12x51 G.HN R 52 G.HN.52
Van-der-waals ICL1 H 103 12x51 G.HN R 52 G.HN.52
Polar ICL2 P 176 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 176 - G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 177 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 177 - G.H5 F 363 G.H5.08
Van-der-waals TM5 D 274 5x73 G.S6 L 346 G.S6.01
Hydrophobic TM6 Q 279 6x22 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 Q 279 6x22 G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term L 413 - G.H2 R 235 G.H2.04
Hydrophobic TM3 V 172 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 172 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 177 - G.S1 V 58 G.S1.02
Hydrophobic TM6 T 290 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 290 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 176 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 176 - G.H5 I 370 G.H5.15
Hydrophobic TM7 C 346 7x54 G.H5 L 380 G.H5.25
Hydrophobic C-term L 413 - G.H2 Q 236 G.H2.05
Hydrophobic TM5 I 272 5x71 G.H5 F 361 G.H5.06
Van-der-waals TM5 I 272 5x71 G.H5 F 361 G.H5.06
Hydrophobic TM5 M 271 5x70 G.S6 F 347 G.S6.02
Hydrophobic ICL2 L 177 - G.H5 V 366 G.H5.11
Hydrophobic TM5 C 269 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM7 L 348 7x56 G.H5 Q 381 G.H5.26
Polar H8 N 349 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 349 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 349 8x47 G.H5 L 380 G.H5.25
Ionic TM5 D 274 5x73 G.S6 H 348 G.S6.03
Polar TM5 D 274 5x73 G.S6 H 348 G.S6.03
Hydrophobic TM5 D 274 5x73 G.S6 H 348 G.S6.03
Van-der-waals TM5 D 274 5x73 G.S6 H 348 G.S6.03
Hydrophobic ICL2 L 177 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 177 - G.H5 I 370 G.H5.15
Polar TM6 Q 279 6x22 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 Q 279 6x22 G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL2 L 177 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 177 - G.S3 I 221 G.S3.01
Hydrophobic TM3 R 169 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM7 L 348 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 348 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM5 L 266 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 266 5x65 G.H5 L 375 G.H5.20
Polar TM3 R 169 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 169 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 169 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 I 173 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 173 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM7 L 348 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 L 348 7x56 G.H5 M 379 G.H5.24
Hydrophobic TM3 I 173 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 173 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM5 M 271 5x70 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 M 271 5x70 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM2 I 110 2x43 G.H5 L 380 G.H5.25
Polar TM3 V 172 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 172 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 V 172 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 177 - G.H5 K 367 G.H5.12
Hydrophobic TM5 I 272 5x71 G.S6 F 347 G.S6.02
Van-der-waals TM5 I 272 5x71 G.S6 F 347 G.S6.02