GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | T | 276 | - | G.H4 | Q | 304 | G.H4.12 |
Polar | TM3 | R | 169 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | F | 381 | - | G.h4s6 | R | 312 | G.h4s6.03 |
Van-der-waals | C-term | F | 381 | - | G.h4s6 | R | 312 | G.h4s6.03 |
Polar | ICL2 | P | 176 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 176 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | K | 265 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Polar | TM4 | T | 184 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM4 | T | 184 | 4x40 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | T | 184 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | ICL2 | P | 176 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 176 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | I | 173 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 173 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | R | 180 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | R | 180 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | R | 180 | - | G.H5 | N | 347 | G.H5.19 |
Polar | TM5 | G | 273 | 5x72 | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | TM5 | G | 273 | 5x72 | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | TM5 | G | 273 | 5x72 | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | C-term | V | 416 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | ICL2 | P | 176 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 176 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | L | 177 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | L | 266 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | I | 272 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | I | 272 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL2 | L | 177 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | L | 177 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Ionic | ICL2 | R | 180 | - | G.H5 | E | 350 | G.H5.22 |
Polar | ICL2 | R | 180 | - | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | ICL2 | R | 180 | - | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | ICL2 | R | 180 | - | G.H5 | E | 350 | G.H5.22 |
Polar | TM6 | T | 290 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 290 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 290 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | R | 180 | - | G.H5 | N | 346 | G.H5.18 |
Polar | TM6 | K | 286 | 6x29 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 286 | 6x29 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | ICL2 | L | 177 | - | G.H5 | I | 343 | G.H5.15 |
Polar | TM4 | S | 182 | 4x38 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM6 | M | 293 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 293 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Polar | TM5 | D | 274 | 5x73 | G.S6 | T | 321 | G.S6.03 |
Van-der-waals | TM5 | D | 274 | 5x73 | G.S6 | T | 321 | G.S6.03 |
Hydrophobic | TM5 | I | 272 | 5x71 | G.H5 | A | 338 | G.H5.10 |
Van-der-waals | TM5 | I | 272 | 5x71 | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | ICL2 | L | 177 | - | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 177 | - | G.S3 | L | 194 | G.S3.01 |
Polar | TM2 | T | 106 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | T | 106 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | T | 106 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | TM5 | D | 274 | 5x73 | G.H4 | Q | 304 | G.H4.12 |
Van-der-waals | TM5 | D | 274 | 5x73 | G.H4 | Q | 304 | G.H4.12 |
Aromatic | C-term | W | 385 | - | G.H3 | K | 248 | G.H3.07 |
Hydrophobic | C-term | W | 385 | - | G.H3 | K | 248 | G.H3.07 |
Van-der-waals | C-term | W | 385 | - | G.H3 | K | 248 | G.H3.07 |
Hydrophobic | TM5 | D | 274 | 5x73 | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | TM5 | D | 274 | 5x73 | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | ICL3 | T | 276 | - | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | TM3 | R | 169 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 169 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | I | 272 | 5x71 | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | TM5 | I | 272 | 5x71 | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | TM6 | K | 286 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 286 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM3 | I | 173 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | I | 173 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | TM4 | S | 182 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | S | 182 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | S | 182 | 4x38 | G.HN | E | 28 | G.HN.52 |
Polar | TM3 | R | 169 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 169 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 169 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Polar | TM3 | V | 172 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | V | 172 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | V | 172 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM7 | L | 348 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | L | 348 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Aromatic | C-term | W | 385 | - | G.H3 | H | 244 | G.H3.03 |
Hydrophobic | C-term | W | 385 | - | G.H3 | H | 244 | G.H3.03 |
Van-der-waals | C-term | W | 385 | - | G.H3 | H | 244 | G.H3.03 |
Polar | TM6 | Q | 279 | 6x22 | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | TM6 | Q | 279 | 6x22 | G.H4 | E | 308 | G.H4.16 |
Van-der-waals | TM6 | Q | 279 | 6x22 | G.H4 | E | 308 | G.H4.16 |
Polar | TM5 | D | 274 | 5x73 | G.S6 | F | 323 | G.S6.05 |
Hydrophobic | TM5 | D | 274 | 5x73 | G.S6 | F | 323 | G.S6.05 |
Van-der-waals | TM5 | D | 274 | 5x73 | G.S6 | F | 323 | G.S6.05 |
Hydrophobic | TM5 | G | 273 | 5x72 | G.S6 | T | 321 | G.S6.03 |
Van-der-waals | TM5 | G | 273 | 5x72 | G.S6 | T | 321 | G.S6.03 |
Hydrophobic | ICL2 | P | 179 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | P | 179 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM7 | L | 348 | 7x56 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM7 | L | 348 | 7x56 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | I | 272 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | I | 272 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | L | 294 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | V | 172 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | V | 172 | 3x53 | G.H5 | C | 351 | G.H5.23 |