Gq - GPR83 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term F 381 - G.H2 H 218 G.H2.09
Van-der-waals C-term F 381 - G.H2 H 218 G.H2.09
Hydrophobic TM5 L 266 5x65 G.H5 L 349 G.H5.16
Hydrophobic TM6 K 286 6x29 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 286 6x29 G.H5 V 359 G.H5.26
Hydrophobic TM5 D 274 5x73 G.H4 L 310 G.H4.12
Hydrophobic ICL2 L 177 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 L 177 - G.H5 I 348 G.H5.15
Hydrophobic ICL3 T 276 - G.H4 V 314 G.H4.16
Van-der-waals TM6 K 289 6x32 G.H5 V 359 G.H5.26
Hydrophobic C-term F 381 - G.H2 C 219 G.H2.10
Van-der-waals C-term F 381 - G.H2 C 219 G.H2.10
Hydrophobic TM3 R 169 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 169 3x50 G.H5 L 358 G.H5.25
Ionic TM5 D 274 5x73 G.S6 H 327 G.S6.04
Polar TM5 D 274 5x73 G.S6 H 327 G.S6.04
Hydrophobic TM5 D 274 5x73 G.S6 H 327 G.S6.04
Van-der-waals TM5 D 274 5x73 G.S6 H 327 G.S6.04
Hydrophobic TM7 L 348 7x56 G.H5 V 359 G.H5.26
Hydrophobic ICL2 L 177 - G.H5 K 345 G.H5.12
Hydrophobic C-term A 384 - G.S2 I 190 G.S2.02
Van-der-waals C-term A 384 - G.S2 I 190 G.S2.02
Hydrophobic ICL2 P 176 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 P 176 - G.H5 I 348 G.H5.15
Hydrophobic C-term W 385 - G.H1 R 60 G.H1.09
Van-der-waals C-term W 385 - G.H1 R 60 G.H1.09
Polar TM5 D 274 5x73 G.S6 F 328 G.S6.05
Hydrophobic TM5 D 274 5x73 G.S6 F 328 G.S6.05
Van-der-waals TM5 D 274 5x73 G.S6 F 328 G.S6.05
Polar C-term W 385 - G.S2 E 191 G.S2.03
Hydrophobic C-term W 385 - G.S2 E 191 G.S2.03
Van-der-waals C-term W 385 - G.S2 E 191 G.S2.03
Hydrophobic ICL2 L 177 - G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 177 - G.H5 F 341 G.H5.08
Hydrophobic TM3 I 173 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 173 3x54 G.H5 L 358 G.H5.25
Hydrophobic ICL2 P 176 - G.H5 K 345 G.H5.12
Hydrophobic TM5 G 273 5x72 G.S6 S 326 G.S6.03
Van-der-waals TM5 G 273 5x72 G.S6 S 326 G.S6.03
Polar ICL2 P 176 - G.H5 N 352 G.H5.19
Hydrophobic C-term P 379 - G.H2 H 218 G.H2.09
Van-der-waals C-term P 379 - G.H2 H 218 G.H2.09
Hydrophobic TM5 I 272 5x71 G.H5 D 346 G.H5.13
Van-der-waals TM5 I 272 5x71 G.H5 D 346 G.H5.13
Hydrophobic C-term L 413 - G.H2 R 214 G.H2.05
Hydrophobic TM6 M 293 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 M 293 6x36 G.H5 L 358 G.H5.25
Hydrophobic TM5 G 273 5x72 G.H5 F 339 G.H5.06
Van-der-waals TM5 G 273 5x72 G.H5 F 339 G.H5.06
Polar TM6 T 290 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 T 290 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 T 290 6x33 G.H5 L 358 G.H5.25
Ionic H8 E 350 8x48 G.H5 K 354 G.H5.21
Polar H8 E 350 8x48 G.H5 K 354 G.H5.21
Hydrophobic H8 E 350 8x48 G.H5 K 354 G.H5.21
Hydrophobic TM6 T 290 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 T 290 6x33 G.H5 V 359 G.H5.26
Hydrophobic TM6 M 293 6x36 G.H5 N 357 G.H5.24
Van-der-waals TM6 M 293 6x36 G.H5 N 357 G.H5.24
Polar TM3 R 169 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 169 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 169 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM6 L 294 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 L 294 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM6 T 290 6x33 G.H5 L 353 G.H5.20
Hydrophobic TM3 I 173 3x54 G.H5 L 349 G.H5.16
Hydrophobic TM7 L 348 7x56 G.H5 L 358 G.H5.25
Polar TM5 D 274 5x73 G.S6 S 326 G.S6.03
Hydrophobic TM5 D 274 5x73 G.S6 S 326 G.S6.03
Van-der-waals TM5 D 274 5x73 G.S6 S 326 G.S6.03
Polar TM2 T 106 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM2 T 106 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 T 106 2x39 G.H5 Y 356 G.H5.23
Hydrophobic TM5 I 272 5x71 G.H5 A 342 G.H5.09
Van-der-waals TM5 I 272 5x71 G.H5 A 342 G.H5.09
Aromatic C-term W 385 - G.S2 Y 192 G.S2.04
Hydrophobic C-term W 385 - G.S2 Y 192 G.S2.04
Van-der-waals C-term W 385 - G.S2 Y 192 G.S2.04
Hydrophobic TM5 I 272 5x71 G.H5 F 339 G.H5.06
Van-der-waals TM5 I 272 5x71 G.H5 F 339 G.H5.06
Hydrophobic TM3 I 173 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 173 3x54 G.H5 L 353 G.H5.20
Hydrophobic ICL2 L 177 - G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL3 T 276 - G.H4 L 310 G.H4.12
Polar H8 N 349 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 N 349 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 N 349 8x47 G.H5 N 357 G.H5.24
Hydrophobic TM6 L 283 6x26 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM7 L 348 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 L 348 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM3 V 172 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 V 172 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM6 Q 279 6x22 G.H4 V 314 G.H4.16
Van-der-waals TM6 Q 279 6x22 G.H4 V 314 G.H4.16
Hydrophobic TM5 I 272 5x71 G.H5 A 343 G.H5.10
Polar C-term V 378 - G.h2s4 E 221 G.h2s4.02
Hydrophobic C-term V 378 - G.h2s4 E 221 G.h2s4.02
Van-der-waals C-term V 378 - G.h2s4 E 221 G.h2s4.02
Ionic TM6 K 286 6x29 G.h4s6 D 321 G.h4s6.12
Polar TM6 K 286 6x29 G.h4s6 D 321 G.h4s6.12
Van-der-waals TM6 K 286 6x29 G.h4s6 D 321 G.h4s6.12
Hydrophobic C-term F 381 - G.S2 E 191 G.S2.03
Van-der-waals C-term F 381 - G.S2 E 191 G.S2.03
Hydrophobic C-term F 381 - G.S1 K 41 G.S1.03
Van-der-waals C-term F 381 - G.S1 K 41 G.S1.03
Polar ICL2 R 180 - G.H5 N 352 G.H5.19
Hydrophobic ICL2 R 180 - G.H5 N 352 G.H5.19
Van-der-waals ICL2 R 180 - G.H5 N 352 G.H5.19
Hydrophobic TM5 I 272 5x71 G.S6 Y 325 G.S6.02
Hydrophobic TM5 L 266 5x65 G.H5 L 353 G.H5.20
Polar TM3 R 169 3x50 G.H5 N 357 G.H5.24
Hydrophobic ICL2 L 177 - G.S1 L 40 G.S1.02
Hydrophobic C-term W 385 - G.S2 P 193 G.S2.05
Hydrophobic ICL2 P 176 - G.H5 L 349 G.H5.16
Polar TM7 Y 345 7x53 G.H5 N 357 G.H5.24
Hydrophobic TM7 Y 345 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 Y 345 7x53 G.H5 N 357 G.H5.24
Polar TM3 V 172 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 V 172 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 V 172 3x53 G.H5 N 352 G.H5.19
Ionic ICL2 R 180 - G.H5 E 355 G.H5.22
Polar ICL2 R 180 - G.H5 E 355 G.H5.22
Hydrophobic ICL2 R 180 - G.H5 E 355 G.H5.22
Van-der-waals ICL2 R 180 - G.H5 E 355 G.H5.22
Polar TM6 Q 279 6x22 G.S6 I 324 G.S6.01
Polar TM3 D 168 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 D 168 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 D 168 3x49 G.H5 Y 356 G.H5.23