G12 - GPR87 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic C-term R 350 - G.H5 D 368 G.H5.13
Polar C-term R 350 - G.H5 D 368 G.H5.13
Van-der-waals C-term R 350 - G.H5 D 368 G.H5.13
Hydrophobic C-term V 349 - G.H4 D 336 G.H4.16
Van-der-waals C-term V 349 - G.H4 D 336 G.H4.16
Hydrophobic C-term R 350 - G.S6 F 347 G.S6.02
Van-der-waals C-term R 350 - G.S6 F 347 G.S6.02
Polar TM3 R 139 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 I 378 G.H5.23
Polar C-term Y 352 - G.S6 H 348 G.S6.03
Polar TM4 S 154 4x38 G.HN R 52 G.HN.52
Hydrophobic TM4 S 154 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 S 154 4x38 G.HN R 52 G.HN.52
Polar TM6 R 248 6x31 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 R 248 6x31 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 H 250 6x33 G.H5 Q 381 G.H5.26
Hydrophobic TM5 I 233 5x65 G.H5 L 375 G.H5.20
Hydrophobic C-term V 349 - G.H4 V 332 G.H4.12
Van-der-waals C-term V 349 - G.H4 V 332 G.H4.12
Hydrophobic ICL2 F 147 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 147 34x51 G.S3 I 221 G.S3.01
Hydrophobic C-term S 347 - G.h4s6 R 339 G.h4s6.08
Van-der-waals C-term S 347 - G.h4s6 R 339 G.h4s6.08
Polar TM5 S 236 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 S 236 5x68 G.H5 D 368 G.H5.13
Polar ICL2 F 147 34x51 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 F 147 34x51 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 F 147 34x51 G.hns1 R 56 G.hns1.03
Polar C-term S 347 - G.h4s6 R 342 G.h4s6.11
Hydrophobic C-term S 347 - G.h4s6 R 342 G.h4s6.11
Van-der-waals C-term S 347 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL2 F 147 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 147 34x51 G.H5 I 370 G.H5.15
Polar TM3 K 142 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 K 142 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 K 142 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 143 3x54 G.H5 L 375 G.H5.20
Polar TM7 M 317 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM7 M 317 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 M 317 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM6 H 250 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 H 250 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM3 K 142 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 K 142 3x53 G.H5 I 378 G.H5.23
Van-der-waals C-term R 345 - G.h4s6 R 342 G.h4s6.11
Aromatic C-term Y 352 - G.H5 F 361 G.H5.06
Hydrophobic C-term Y 352 - G.H5 F 361 G.H5.06
Van-der-waals C-term Y 352 - G.H5 F 361 G.H5.06
Hydrophobic TM7 M 317 7x56 G.H5 I 378 G.H5.23
Van-der-waals TM7 M 317 7x56 G.H5 I 378 G.H5.23
Polar ICL3 Q 239 - G.H5 H 364 G.H5.09
Hydrophobic ICL3 Q 239 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 Q 239 - G.H5 H 364 G.H5.09
Hydrophobic ICL2 F 147 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 F 147 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 147 34x51 G.S1 V 58 G.S1.02
Polar C-term R 350 - G.S6 L 346 G.S6.01
Van-der-waals C-term R 350 - G.S6 L 346 G.S6.01
Aromatic ICL3 F 240 - G.S6 F 347 G.S6.02
Hydrophobic ICL3 F 240 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 F 240 - G.S6 F 347 G.S6.02
Hydrophobic ICL2 F 147 34x51 G.H5 V 366 G.H5.11
Polar C-term E 348 - G.S6 L 346 G.S6.01
Van-der-waals C-term E 348 - G.S6 L 346 G.S6.01
Polar TM6 R 248 6x31 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 248 6x31 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 248 6x31 G.H5 Q 381 G.H5.26
Polar C-term S 347 - G.H4 D 336 G.H4.16
Hydrophobic C-term S 347 - G.H4 D 336 G.H4.16
Van-der-waals C-term S 347 - G.H4 D 336 G.H4.16
Hydrophobic TM3 V 143 3x54 G.H5 I 378 G.H5.23
Hydrophobic C-term I 351 - G.S6 H 348 G.S6.03
Van-der-waals C-term I 351 - G.S6 H 348 G.S6.03
Ionic C-term D 354 - G.H5 R 360 G.H5.05
Polar TM7 M 317 7x56 G.H5 M 379 G.H5.24
Polar H8 R 319 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 319 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 319 8x48 G.H5 Q 381 G.H5.26
Polar ICL1 K 73 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 K 73 - G.hns1 R 55 G.hns1.02
Hydrophobic C-term E 348 - G.h4s6 P 345 G.h4s6.20
Van-der-waals C-term E 348 - G.h4s6 P 345 G.h4s6.20
Polar C-term R 350 - G.S6 H 348 G.S6.03
Hydrophobic C-term R 350 - G.S6 H 348 G.S6.03
Van-der-waals C-term R 350 - G.S6 H 348 G.S6.03
Hydrophobic H8 R 319 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 R 319 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 146 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL3 F 240 - G.H5 A 365 G.H5.10
Van-der-waals ICL3 F 240 - G.H5 A 365 G.H5.10
Hydrophobic C-term V 349 - G.S6 H 348 G.S6.03
Van-der-waals C-term V 349 - G.S6 H 348 G.S6.03
Hydrophobic ICL2 P 146 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 146 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL3 F 240 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 F 240 - G.H5 D 368 G.H5.13
Polar C-term E 348 - G.h4s6 R 339 G.h4s6.08
Van-der-waals C-term E 348 - G.h4s6 R 339 G.h4s6.08
Polar TM6 H 250 6x33 G.H5 Q 372 G.H5.17
Hydrophobic TM6 H 250 6x33 G.H5 Q 372 G.H5.17
Van-der-waals TM6 H 250 6x33 G.H5 Q 372 G.H5.17
Hydrophobic TM5 S 236 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 S 236 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM3 V 143 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 143 3x54 G.H5 L 371 G.H5.16
Polar ICL2 Y 153 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Y 153 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 H 250 6x33 G.H5 L 375 G.H5.20
Hydrophobic H8 C 318 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 C 318 8x47 G.H5 L 380 G.H5.25
Polar TM5 Y 232 5x64 G.H5 K 367 G.H5.12
Hydrophobic TM5 Y 232 5x64 G.H5 K 367 G.H5.12
Van-der-waals TM5 Y 232 5x64 G.H5 K 367 G.H5.12
Hydrophobic ICL3 F 240 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 F 240 - G.H5 H 364 G.H5.09
Hydrophobic TM5 Y 232 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM5 Y 232 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM7 F 315 7x54 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 315 7x54 G.H5 L 380 G.H5.25
Hydrophobic H8 S 322 8x51 G.H5 L 380 G.H5.25
Van-der-waals H8 S 322 8x51 G.H5 L 380 G.H5.25
Polar ICL2 G 148 34x52 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 G 148 34x52 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 G 148 34x52 G.hns1 R 56 G.hns1.03
Polar TM7 F 316 7x55 G.H5 L 380 G.H5.25
Hydrophobic TM7 F 316 7x55 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 316 7x55 G.H5 L 380 G.H5.25
Hydrophobic C-term R 350 - G.h4s6 P 345 G.h4s6.20
Van-der-waals C-term R 350 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 S 253 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 253 6x36 G.H5 M 379 G.H5.24
Polar TM6 S 253 6x36 G.H5 I 378 G.H5.23
Hydrophobic TM6 S 253 6x36 G.H5 I 378 G.H5.23
Van-der-waals C-term V 349 - G.S6 L 346 G.S6.01
Ionic ICL2 D 149 34x53 G.hns1 R 56 G.hns1.03
Polar ICL2 D 149 34x53 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 D 149 34x53 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 D 149 34x53 G.hns1 R 56 G.hns1.03
Polar C-term Y 352 - G.H5 H 364 G.H5.09
Hydrophobic C-term Y 352 - G.H5 H 364 G.H5.09
Van-der-waals C-term Y 352 - G.H5 H 364 G.H5.09