GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM6 | S | 253 | 6x36 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM6 | S | 253 | 6x36 | G.H5 | I | 371 | G.H5.23 |
Polar | C-term | S | 347 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | S | 347 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | S | 347 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | V | 349 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | V | 349 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | V | 344 | - | G.H2 | I | 220 | G.H2.08 |
Polar | C-term | Y | 355 | - | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | C-term | Y | 355 | - | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | C-term | Y | 355 | - | G.S1 | E | 42 | G.S1.01 |
Polar | C-term | T | 356 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | C-term | T | 356 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | T | 356 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | C-term | V | 349 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | TM3 | K | 142 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | K | 142 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | Y | 355 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | Y | 355 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | Y | 355 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | TM3 | V | 143 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM2 | T | 74 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM5 | I | 233 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | L | 341 | - | G.H3 | W | 266 | G.H3.17 |
Polar | ICL2 | F | 147 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | F | 147 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | F | 147 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Polar | ICL3 | Q | 239 | - | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | ICL3 | Q | 239 | - | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | ICL3 | Q | 239 | - | G.H5 | K | 357 | G.H5.09 |
Polar | TM7 | F | 316 | 7x55 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM7 | F | 316 | 7x55 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | F | 316 | 7x55 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | F | 147 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | F | 147 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | ICL3 | F | 240 | - | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | ICL3 | F | 240 | - | G.H5 | L | 364 | G.H5.16 |
Polar | TM6 | H | 250 | 6x33 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | H | 250 | 6x33 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | H | 250 | 6x33 | G.H5 | L | 374 | G.H5.26 |
Polar | C-term | D | 354 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | D | 354 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | D | 354 | - | G.S2 | C | 196 | G.S2.05 |
Polar | TM6 | S | 253 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM4 | I | 155 | 4x39 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | Y | 355 | - | G.S3 | N | 203 | G.S3.02 |
Van-der-waals | C-term | Y | 355 | - | G.S3 | N | 203 | G.S3.02 |
Hydrophobic | ICL2 | F | 147 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | F | 147 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Polar | ICL3 | F | 240 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL3 | F | 240 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | ICL3 | F | 240 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL3 | F | 240 | - | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | ICL3 | F | 240 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM6 | I | 254 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | I | 254 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM5 | Y | 232 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | Y | 232 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM6 | R | 246 | 6x29 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | C-term | Y | 352 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | Y | 352 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | Y | 352 | - | G.S2 | E | 194 | G.S2.03 |
Polar | H8 | R | 319 | 8x48 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | H8 | R | 319 | 8x48 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | H8 | R | 319 | 8x48 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | C-term | L | 341 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | L | 341 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | Y | 352 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | C-term | Y | 355 | - | G.S2 | F | 197 | G.S2.06 |
Polar | C-term | D | 357 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | C-term | D | 357 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | ICL2 | F | 147 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | TM5 | I | 233 | 5x65 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | V | 143 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | F | 147 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | F | 147 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM3 | V | 143 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | V | 143 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Polar | C-term | R | 350 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | R | 350 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | I | 351 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | I | 351 | - | G.S2 | E | 194 | G.S2.03 |
Polar | C-term | T | 356 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | C-term | T | 356 | - | G.h1ha | G | 67 | G.h1ha.01 |
Van-der-waals | C-term | T | 356 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | ICL2 | F | 147 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Polar | C-term | R | 350 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | R | 350 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | Y | 353 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | Y | 353 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | R | 350 | - | G.S2 | N | 193 | G.S2.02 |
Van-der-waals | C-term | R | 350 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | ICL2 | P | 146 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Ionic | H8 | R | 319 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | R | 319 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | H8 | R | 319 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | H8 | R | 319 | 8x48 | G.H5 | D | 369 | G.H5.21 |
Polar | TM6 | H | 250 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | H | 250 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | H | 250 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | T | 356 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | T | 356 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | ICL2 | P | 146 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | P | 146 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM3 | V | 143 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM3 | D | 138 | 3x49 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | V | 358 | - | G.H1 | H | 66 | G.H1.12 |
Polar | C-term | V | 358 | - | G.s2s3 | Q | 200 | G.s2s3.01 |
Polar | C-term | V | 344 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | V | 344 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | V | 344 | - | G.H2 | H | 221 | G.H2.09 |
Polar | C-term | R | 345 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | R | 345 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | R | 345 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | T | 356 | - | G.S2 | S | 198 | G.S2.07 |
Van-der-waals | C-term | T | 356 | - | G.S2 | S | 198 | G.S2.07 |
Polar | C-term | Y | 352 | - | G.S2 | Y | 195 | G.S2.04 |
Aromatic | C-term | Y | 352 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | C-term | Y | 352 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | Y | 352 | - | G.S2 | Y | 195 | G.S2.04 |
Ionic | ICL2 | D | 149 | 34x53 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | ICL2 | D | 149 | 34x53 | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | ICL2 | D | 149 | 34x53 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | TM3 | R | 139 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 139 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | S | 253 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | S | 253 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM7 | M | 317 | 7x56 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM7 | M | 317 | 7x56 | G.H5 | I | 371 | G.H5.23 |
Polar | C-term | Y | 352 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | Y | 352 | - | G.S2 | C | 196 | G.S2.05 |
Polar | C-term | Y | 353 | - | G.S3 | R | 205 | G.S3.04 |
Ionic | C-term | D | 354 | - | G.H1 | R | 63 | G.H1.09 |
Polar | C-term | D | 354 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | D | 354 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | D | 354 | - | G.H1 | R | 63 | G.H1.09 |
Polar | H8 | S | 322 | 8x51 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | S | 347 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | S | 347 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | H8 | R | 319 | 8x48 | G.H5 | N | 372 | G.H5.24 |