Golf - GPR88 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 80.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 E 341 8x48 G.H5 E 379 G.H5.24
Hydrophobic H8 E 341 8x48 G.H5 E 379 G.H5.24
Van-der-waals H8 E 341 8x48 G.H5 E 379 G.H5.24
Polar ICL3 S 282 - G.H5 L 380 G.H5.25
Hydrophobic ICL3 S 282 - G.H5 L 380 G.H5.25
Van-der-waals ICL3 S 282 - G.H5 L 380 G.H5.25
Polar TM3 L 141 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 L 141 3x53 G.H5 H 374 G.H5.19
Van-der-waals TM3 L 141 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM5 V 219 5x65 G.H5 L 381 G.H5.26
Hydrophobic TM5 V 219 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 V 219 5x65 G.H5 L 375 G.H5.20
Polar TM3 I 142 3x54 G.H5 Q 371 G.H5.16
Van-der-waals TM3 I 142 3x54 G.H5 Q 371 G.H5.16
Polar ICL3 Q 278 - G.h4s6 G 342 G.h4s6.11
Hydrophobic ICL3 Q 278 - G.h4s6 G 342 G.h4s6.11
Van-der-waals ICL3 Q 278 - G.h4s6 G 342 G.h4s6.11
Hydrophobic ICL3 Q 278 - G.H5 L 381 G.H5.26
Van-der-waals ICL3 Q 278 - G.H5 L 381 G.H5.26
Hydrophobic ICL3 L 234 - G.h4s6 G 342 G.h4s6.11
Van-der-waals ICL3 L 234 - G.h4s6 G 342 G.h4s6.11
Hydrophobic TM5 V 226 5x72 G.H5 R 372 G.H5.17
Van-der-waals TM5 V 226 5x72 G.H5 R 372 G.H5.17
Hydrophobic TM6 S 285 6x36 G.H5 L 380 G.H5.25
Ionic H8 R 344 8x51 G.H5 E 379 G.H5.24
Van-der-waals TM5 V 223 5x69 G.H5 R 372 G.H5.17
Polar ICL2 Q 150 34x54 G.hns1 A 41 G.hns1.03
Hydrophobic ICL2 Q 150 34x54 G.hns1 A 41 G.hns1.03
Van-der-waals ICL2 Q 150 34x54 G.hns1 A 41 G.hns1.03
Hydrophobic TM3 I 142 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 146 34x50 G.S1 H 43 G.S1.02
Hydrophobic ICL3 L 234 - G.h4s6 Y 345 G.h4s6.20
Polar H8 N 340 8x47 G.H5 E 379 G.H5.24
Hydrophobic H8 N 340 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 N 340 8x47 G.H5 E 379 G.H5.24
Hydrophobic ICL3 L 234 - G.h4s6 G 340 G.h4s6.09
Polar TM5 R 218 5x64 G.H5 Q 371 G.H5.16
Hydrophobic TM5 R 218 5x64 G.H5 Q 371 G.H5.16
Van-der-waals TM5 R 218 5x64 G.H5 Q 371 G.H5.16
Hydrophobic TM3 I 142 3x54 G.H5 H 374 G.H5.19
Hydrophobic TM3 L 141 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM3 L 141 3x53 G.H5 Y 378 G.H5.23
Hydrophobic TM5 V 226 5x72 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM5 V 223 5x69 G.H5 L 381 G.H5.26
Hydrophobic TM3 R 138 3x50 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 P 146 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM6 V 286 6x37 G.H5 L 380 G.H5.25
Van-der-waals TM6 V 286 6x37 G.H5 L 380 G.H5.25
Polar TM2 S 66 2x39 G.H5 Y 378 G.H5.23
Hydrophobic TM2 S 66 2x39 G.H5 Y 378 G.H5.23
Van-der-waals TM2 S 66 2x39 G.H5 Y 378 G.H5.23
Hydrophobic TM5 I 215 5x61 G.H5 L 380 G.H5.25
Van-der-waals TM5 I 215 5x61 G.H5 L 380 G.H5.25
Polar H8 N 340 8x47 G.H5 Q 377 G.H5.22
Polar ICL2 Q 150 34x54 G.hns1 K 40 G.hns1.02
Hydrophobic ICL2 Q 150 34x54 G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 Q 150 34x54 G.hns1 K 40 G.hns1.02
Hydrophobic TM3 I 142 3x54 G.H5 L 380 G.H5.25
Polar TM5 R 225 5x71 G.H5 N 364 G.H5.09
Hydrophobic TM5 R 225 5x71 G.H5 N 364 G.H5.09
Van-der-waals TM5 R 225 5x71 G.H5 N 364 G.H5.09
Hydrophobic ICL3 S 282 - G.H5 L 381 G.H5.26
Polar TM5 S 222 5x68 G.H5 R 372 G.H5.17
Hydrophobic TM5 S 222 5x68 G.H5 R 372 G.H5.17
Van-der-waals TM5 S 222 5x68 G.H5 R 372 G.H5.17
Hydrophobic TM5 V 226 5x72 G.S6 Y 347 G.S6.02
Van-der-waals TM5 V 226 5x72 G.S6 Y 347 G.S6.02
Hydrophobic ICL3 F 231 - G.h4s6 T 337 G.h4s6.03
Hydrophobic TM5 I 215 5x61 G.H5 L 375 G.H5.20
Hydrophobic ICL3 L 229 - G.S6 Y 347 G.S6.02
Van-der-waals ICL3 L 229 - G.S6 Y 347 G.S6.02
Polar ICL3 Q 278 - G.h4s6 Y 345 G.h4s6.20
Van-der-waals ICL3 Q 278 - G.h4s6 Y 345 G.h4s6.20
Polar TM5 S 222 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 S 222 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 S 222 5x68 G.H5 D 368 G.H5.13
Polar ICL4 R 339 - G.H5 E 379 G.H5.24
Hydrophobic ICL4 R 339 - G.H5 E 379 G.H5.24
Van-der-waals ICL4 R 339 - G.H5 E 379 G.H5.24
Hydrophobic ICL3 L 229 - G.S6 P 348 G.S6.03
Van-der-waals ICL3 L 229 - G.S6 P 348 G.S6.03
Hydrophobic TM5 V 226 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 V 226 5x72 G.H5 D 368 G.H5.13