GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM2 | S | 66 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | S | 66 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | S | 66 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | H | 235 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | ICL3 | H | 235 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | I | 142 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Polar | ICL2 | Q | 150 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 150 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 150 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM5 | I | 215 | 5x61 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM5 | R | 225 | 5x71 | G.H5 | A | 342 | G.H5.09 |
Polar | TM3 | N | 137 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | N | 137 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | N | 137 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM3 | L | 141 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | L | 141 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Polar | ICL3 | Q | 278 | - | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | ICL3 | Q | 278 | - | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | ICL3 | Q | 278 | - | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM5 | V | 226 | 5x72 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | ICL3 | R | 279 | - | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | ICL3 | R | 279 | - | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM5 | R | 218 | 5x64 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | TM5 | R | 218 | 5x64 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM5 | S | 222 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | S | 222 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL3 | L | 229 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ICL4 | R | 339 | - | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | ICL4 | R | 339 | - | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL3 | H | 232 | - | G.H4 | L | 310 | G.H4.12 |
Van-der-waals | ICL3 | H | 232 | - | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | TM5 | V | 219 | 5x65 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL3 | L | 234 | - | G.H4 | V | 314 | G.H4.16 |
Polar | TM7 | Y | 336 | 7x53 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | Y | 336 | 7x53 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL3 | L | 229 | - | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | ICL3 | L | 229 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | ICL3 | Q | 278 | - | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | ICL3 | Q | 278 | - | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM3 | L | 141 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | L | 141 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Ionic | ICL3 | R | 279 | - | G.H5 | D | 346 | G.H5.13 |
Polar | ICL3 | R | 279 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | ICL3 | R | 279 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | ICL3 | R | 279 | - | G.H5 | D | 346 | G.H5.13 |
Polar | TM6 | S | 285 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | S | 285 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL3 | F | 231 | - | G.H5 | A | 342 | G.H5.09 |
Polar | ICL3 | H | 235 | - | G.h4s6 | K | 322 | G.h4s6.13 |
Hydrophobic | ICL3 | H | 235 | - | G.h4s6 | K | 322 | G.h4s6.13 |
Hydrophobic | ICL3 | S | 282 | - | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | ICL3 | S | 282 | - | G.H5 | L | 358 | G.H5.25 |
Polar | TM4 | Q | 154 | 4x38 | G.HN | R | 34 | G.HN.52 |
Hydrophobic | TM4 | Q | 154 | 4x38 | G.HN | R | 34 | G.HN.52 |
Van-der-waals | TM4 | Q | 154 | 4x38 | G.HN | R | 34 | G.HN.52 |
Hydrophobic | TM5 | Y | 212 | 5x58 | G.H5 | L | 358 | G.H5.25 |
Aromatic | ICL3 | F | 231 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ICL3 | F | 231 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | ICL3 | F | 231 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | TM3 | R | 138 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | S | 285 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL4 | R | 339 | - | G.H5 | N | 357 | G.H5.24 |
Polar | ICL3 | H | 235 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | ICL3 | H | 235 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | ICL3 | H | 235 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | ICL3 | S | 282 | - | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | ICL3 | S | 282 | - | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | A | 147 | 34x51 | G.hns1 | R | 38 | G.hns1.03 |
Aromatic | ICL3 | F | 231 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | ICL3 | F | 231 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | ICL3 | F | 231 | - | G.S6 | Y | 325 | G.S6.02 |
Polar | H8 | N | 340 | 8x47 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | N | 352 | G.H5.19 |
Polar | H8 | N | 340 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | N | 340 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | N | 340 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Ionic | ICL3 | H | 232 | - | G.H4 | E | 307 | G.H4.09 |
Polar | ICL3 | H | 232 | - | G.H4 | E | 307 | G.H4.09 |
Hydrophobic | TM5 | V | 226 | 5x72 | G.S6 | Y | 325 | G.S6.02 |
Polar | TM3 | R | 138 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 138 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 138 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | F | 231 | - | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | ICL3 | L | 233 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | I | 142 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Polar | ICL2 | Y | 149 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | Y | 149 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | H | 235 | - | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM3 | I | 142 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | I | 142 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM5 | I | 215 | 5x61 | G.H5 | L | 358 | G.H5.25 |
Polar | TM5 | S | 222 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM5 | S | 222 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | ICL3 | L | 233 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | TM6 | V | 286 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM5 | V | 219 | 5x65 | G.H5 | L | 353 | G.H5.20 |