G15 -
mGlu2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 25.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | I | 660 | 3x57 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | I | 660 | 3x57 | G.H5 | I | 371 | G.H5.23 |
Polar | ICL2 | R | 670 | - | G.h2s4 | N | 225 | G.h2s4.03 |
Polar | ICL2 | R | 665 | - | G.S3 | N | 203 | G.S3.02 |
Hydrophobic | ICL2 | R | 665 | - | G.S3 | N | 203 | G.S3.02 |
Van-der-waals | ICL2 | R | 665 | - | G.S3 | N | 203 | G.S3.02 |
Hydrophobic | ICL2 | G | 667 | - | G.HN | Q | 35 | G.HN.50 |
Van-der-waals | ICL2 | G | 667 | - | G.HN | Q | 35 | G.HN.50 |
Hydrophobic | TM3 | I | 657 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL3 | P | 753 | - | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | ICL3 | P | 753 | - | G.H5 | L | 364 | G.H5.16 |
Ionic | H8 | R | 829 | 8x54 | G.H5 | D | 361 | G.H5.13 |
Polar | H8 | R | 829 | 8x54 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | ICL3 | P | 753 | - | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL3 | P | 753 | - | G.S3 | T | 202 | G.S3.01 |
Polar | ICL2 | G | 667 | - | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | ICL2 | G | 667 | - | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | TM3 | F | 661 | 3x58 | G.H5 | L | 364 | G.H5.16 |
Polar | ICL2 | G | 667 | - | G.HN | Q | 38 | G.HN.53 |
Hydrophobic | ICL2 | G | 667 | - | G.HN | Q | 38 | G.HN.53 |
Van-der-waals | ICL2 | G | 667 | - | G.HN | Q | 38 | G.HN.53 |
Hydrophobic | ICL2 | I | 674 | - | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | ICL2 | I | 674 | - | G.H5 | I | 371 | G.H5.23 |
Polar | TM3 | G | 663 | 3x60 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | TM3 | G | 663 | 3x60 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | TM3 | G | 663 | 3x60 | G.hns1 | G | 41 | G.hns1.03 |
Polar | ICL2 | Q | 669 | - | G.HN | K | 36 | G.HN.51 |
Hydrophobic | ICL2 | Q | 669 | - | G.HN | K | 36 | G.HN.51 |
Van-der-waals | ICL2 | Q | 669 | - | G.HN | K | 36 | G.HN.51 |
Hydrophobic | C-term | V | 858 | - | G.S2 | Y | 195 | G.S2.04 |
Ionic | ICL2 | R | 670 | - | G.H5 | E | 370 | G.H5.22 |
Polar | ICL2 | R | 670 | - | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL1 | P | 596 | 12x48 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | ICL1 | P | 596 | 12x48 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | R | 672 | - | G.HN | L | 33 | G.HN.48 |
Polar | TM3 | G | 663 | 3x60 | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | ICL1 | A | 600 | 12x52 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | ICL1 | A | 600 | 12x52 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL2 | G | 667 | - | G.hns1 | R | 40 | G.hns1.02 |
Polar | ICL1 | A | 600 | 12x52 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL1 | A | 600 | 12x52 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | ICL1 | A | 600 | 12x52 | G.H5 | L | 374 | G.H5.26 |
Polar | H8 | H | 828 | 8x53 | G.h4s6 | R | 338 | G.h4s6.20 |
Aromatic | H8 | H | 828 | 8x53 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | H8 | H | 828 | 8x53 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | H8 | H | 828 | 8x53 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | F | 756 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | F | 756 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL2 | R | 670 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | R | 670 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | R | 670 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM3 | I | 660 | 3x57 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM2 | G | 602 | 2x35 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL1 | K | 599 | 12x51 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | ICL1 | K | 599 | 12x51 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM3 | I | 660 | 3x57 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM3 | I | 660 | 3x57 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL2 | A | 664 | - | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | ICL2 | A | 664 | - | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | ICL2 | A | 664 | - | G.S1 | E | 42 | G.S1.01 |
Polar | ICL2 | Q | 669 | - | G.HN | L | 32 | G.HN.47 |
Van-der-waals | ICL2 | Q | 669 | - | G.HN | L | 32 | G.HN.47 |
Polar | ICL2 | E | 666 | - | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | ICL2 | E | 666 | - | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | ICL2 | E | 666 | - | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | H8 | V | 826 | 8x51 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | H8 | V | 826 | 8x51 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | ICL2 | E | 666 | - | G.HN | Q | 38 | G.HN.53 |
Hydrophobic | ICL2 | E | 666 | - | G.HN | Q | 38 | G.HN.53 |
Van-der-waals | ICL2 | E | 666 | - | G.HN | Q | 38 | G.HN.53 |
Polar | C-term | F | 854 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | C-term | F | 854 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | F | 854 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | ICL1 | A | 600 | 12x52 | G.H5 | N | 372 | G.H5.24 |
Polar | ICL2 | Q | 669 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 669 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 669 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM6 | F | 756 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | F | 756 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | P | 856 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | P | 856 | - | G.h1ha | A | 68 | G.h1ha.02 |
Polar | ICL2 | A | 668 | - | G.h2s4 | N | 225 | G.h2s4.03 |
Van-der-waals | ICL2 | A | 668 | - | G.h2s4 | N | 225 | G.h2s4.03 |
Hydrophobic | TM3 | G | 663 | 3x60 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL1 | K | 599 | 12x51 | G.h4s6 | A | 334 | G.h4s6.16 |
Van-der-waals | TM6 | E | 758 | 6x35 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | F | 661 | 3x58 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | TM3 | F | 661 | 3x58 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM4 | P | 676 | 4x29 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM4 | P | 676 | 4x29 | G.H5 | N | 372 | G.H5.24 |
Polar | ICL2 | G | 667 | - | G.HN | K | 36 | G.HN.51 |
Hydrophobic | ICL2 | G | 667 | - | G.HN | K | 36 | G.HN.51 |
Van-der-waals | ICL2 | G | 667 | - | G.HN | K | 36 | G.HN.51 |
Hydrophobic | ICL2 | P | 671 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | P | 671 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | TM3 | G | 663 | 3x60 | G.HN | Q | 38 | G.HN.53 |
Van-der-waals | TM3 | G | 663 | 3x60 | G.HN | Q | 38 | G.HN.53 |
Hydrophobic | ICL2 | G | 667 | - | G.S3 | R | 205 | G.S3.04 |
Polar | TM3 | R | 656 | 3x53 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM3 | R | 656 | 3x53 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | E | 666 | - | G.hns1 | D | 39 | G.hns1.01 |
Hydrophobic | ICL2 | Q | 669 | - | G.HN | L | 33 | G.HN.48 |
Van-der-waals | ICL2 | Q | 669 | - | G.HN | L | 33 | G.HN.48 |
Hydrophobic | TM6 | F | 756 | 6x33 | G.H5 | L | 364 | G.H5.16 |
Polar | ICL2 | A | 664 | - | G.S3 | N | 203 | G.S3.02 |
Hydrophobic | ICL2 | A | 664 | - | G.S3 | N | 203 | G.S3.02 |
Van-der-waals | ICL2 | A | 664 | - | G.S3 | N | 203 | G.S3.02 |
Hydrophobic | ICL2 | A | 664 | - | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | A | 664 | - | G.hns1 | G | 41 | G.hns1.03 |
Polar | ICL2 | G | 667 | - | G.hns1 | D | 39 | G.hns1.01 |
Hydrophobic | ICL2 | G | 667 | - | G.hns1 | D | 39 | G.hns1.01 |
Van-der-waals | ICL2 | G | 667 | - | G.hns1 | D | 39 | G.hns1.01 |
Hydrophobic | TM3 | R | 656 | 3x53 | G.H5 | L | 373 | G.H5.25 |
Polar | TM5 | R | 750 | 5x62 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | ICL2 | A | 668 | - | G.HN | K | 36 | G.HN.51 |
Van-der-waals | ICL2 | A | 668 | - | G.HN | K | 36 | G.HN.51 |
Polar | TM3 | I | 660 | 3x57 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | TM3 | I | 660 | 3x57 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | TM3 | I | 660 | 3x57 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | C-term | V | 855 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | V | 855 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | C-term | P | 856 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | ICL2 | R | 672 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | R | 672 | - | G.hns1 | R | 40 | G.hns1.02 |
Polar | ICL3 | N | 755 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | ICL3 | N | 755 | - | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | ICL3 | N | 755 | - | G.H5 | D | 361 | G.H5.13 |
Polar | ICL2 | A | 668 | - | G.HN | Q | 35 | G.HN.50 |
Van-der-waals | ICL2 | A | 668 | - | G.HN | Q | 35 | G.HN.50 |
Polar | ICL1 | K | 599 | 12x51 | G.H5 | L | 373 | G.H5.25 |
Polar | TM3 | G | 663 | 3x60 | G.hns1 | D | 39 | G.hns1.01 |
Hydrophobic | TM5 | K | 751 | 5x63 | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | TM5 | K | 751 | 5x63 | G.s2s3 | K | 201 | G.s2s3.02 |
Polar | ICL2 | A | 668 | - | G.hns1 | D | 39 | G.hns1.01 |
Hydrophobic | ICL2 | A | 668 | - | G.hns1 | D | 39 | G.hns1.01 |
Van-der-waals | ICL2 | A | 668 | - | G.hns1 | D | 39 | G.hns1.01 |
Hydrophobic | ICL1 | K | 599 | 12x51 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | ICL1 | K | 599 | 12x51 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | R | 665 | - | G.S1 | E | 42 | G.S1.01 |
Polar | TM3 | R | 656 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 656 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 656 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Polar | ICL2 | G | 667 | - | G.HN | K | 37 | G.HN.52 |