Golf -
mGlu2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL1 | S | 601 | 12x53 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | I | 660 | 3x57 | G.H5 | Q | 371 | G.H5.16 |
Polar | C-term | T | 869 | - | G.hfs2 | S | 192 | G.hfs2.06 |
Hydrophobic | C-term | T | 869 | - | G.hfs2 | S | 192 | G.hfs2.06 |
Van-der-waals | C-term | T | 869 | - | G.hfs2 | S | 192 | G.hfs2.06 |
Hydrophobic | TM3 | F | 661 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Polar | TM3 | R | 656 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 656 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 656 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | C-term | F | 835 | - | G.H4 | F | 327 | G.H4.10 |
Hydrophobic | H8 | R | 829 | 8x54 | G.h4s6 | T | 337 | G.h4s6.03 |
Van-der-waals | H8 | R | 829 | 8x54 | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | ICL2 | G | 667 | - | G.S3 | V | 204 | G.S3.01 |
Ionic | TM2 | R | 603 | 2x36 | G.H5 | E | 379 | G.H5.24 |
Polar | TM2 | R | 603 | 2x36 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM2 | R | 603 | 2x36 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM2 | R | 603 | 2x36 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM4 | S | 675 | 4x28 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM4 | S | 675 | 4x28 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM2 | G | 602 | 2x35 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | G | 602 | 2x35 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | R | 670 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | R | 670 | - | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | R | 670 | - | G.H5 | H | 374 | G.H5.19 |
Polar | ICL2 | P | 671 | - | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | ICL2 | P | 671 | - | G.H5 | Y | 378 | G.H5.23 |
Polar | ICL2 | R | 670 | - | G.H5 | M | 373 | G.H5.18 |
Hydrophobic | ICL2 | R | 670 | - | G.H5 | M | 373 | G.H5.18 |
Van-der-waals | ICL2 | R | 670 | - | G.H5 | M | 373 | G.H5.18 |
Polar | C-term | N | 860 | - | G.s4h3 | D | 247 | G.s4h3.11 |
Van-der-waals | C-term | V | 858 | - | G.s4h3 | N | 248 | G.s4h3.12 |
Polar | ICL2 | I | 674 | - | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | I | 674 | - | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | ICL2 | I | 674 | - | G.H5 | Y | 378 | G.H5.23 |
Polar | H8 | H | 828 | 8x53 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | H8 | H | 828 | 8x53 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | H8 | H | 828 | 8x53 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | C-term | F | 835 | - | G.H4 | L | 331 | G.H4.14 |
Van-der-waals | C-term | F | 835 | - | G.H4 | L | 331 | G.H4.14 |
Hydrophobic | C-term | F | 835 | - | G.hgh4 | E | 301 | G.hgh4.04 |
Van-der-waals | C-term | F | 835 | - | G.hgh4 | E | 301 | G.hgh4.04 |
Ionic | C-term | R | 834 | - | G.H4 | D | 330 | G.H4.13 |
Hydrophobic | H8 | R | 829 | 8x54 | G.S6 | P | 348 | G.S6.03 |
Van-der-waals | H8 | R | 829 | 8x54 | G.S6 | P | 348 | G.S6.03 |
Hydrophobic | C-term | C | 859 | - | H.HD | E | 155 | H.HD.12 |
Van-der-waals | C-term | C | 859 | - | H.HD | E | 155 | H.HD.12 |
Hydrophobic | TM3 | I | 660 | 3x57 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | A | 668 | - | G.hns1 | A | 41 | G.hns1.03 |
Van-der-waals | ICL2 | A | 668 | - | G.hns1 | A | 41 | G.hns1.03 |
Hydrophobic | C-term | F | 835 | - | G.H4 | D | 330 | G.H4.13 |
Van-der-waals | C-term | R | 862 | - | G.s4h3 | N | 248 | G.s4h3.12 |
Hydrophobic | TM6 | F | 756 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | F | 756 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | Q | 669 | - | G.hns1 | A | 41 | G.hns1.03 |
Ionic | C-term | R | 834 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | C-term | R | 834 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | C-term | R | 834 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | ICL2 | Q | 669 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | ICL2 | Q | 669 | - | G.HN | L | 37 | G.HN.52 |
Polar | C-term | G | 861 | - | G.s4h3 | N | 248 | G.s4h3.12 |
Hydrophobic | C-term | G | 861 | - | G.s4h3 | N | 248 | G.s4h3.12 |
Van-der-waals | C-term | G | 861 | - | G.s4h3 | N | 248 | G.s4h3.12 |
Hydrophobic | C-term | G | 861 | - | H.hdhe | Q | 157 | H.hdhe.02 |
Van-der-waals | C-term | G | 861 | - | H.hdhe | Q | 157 | H.hdhe.02 |
Hydrophobic | TM3 | R | 656 | 3x53 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | R | 656 | 3x53 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL1 | A | 600 | 12x52 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL1 | A | 600 | 12x52 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | ICL1 | A | 600 | 12x52 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | A | 668 | - | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | ICL2 | Q | 669 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL2 | A | 664 | - | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL2 | A | 664 | - | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | I | 660 | 3x57 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | C-term | V | 858 | - | G.s4h3 | V | 243 | G.s4h3.07 |
Van-der-waals | C-term | V | 858 | - | G.s4h3 | V | 243 | G.s4h3.07 |
Hydrophobic | ICL1 | K | 599 | 12x51 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | ICL1 | K | 599 | 12x51 | G.H5 | E | 379 | G.H5.24 |
Polar | C-term | E | 863 | - | H.HA | T | 92 | H.HA.21 |
Hydrophobic | C-term | R | 834 | - | G.hgh4 | Y | 305 | G.hgh4.08 |
Polar | C-term | N | 860 | - | G.s4h3 | N | 248 | G.s4h3.12 |
Hydrophobic | C-term | N | 860 | - | G.s4h3 | N | 248 | G.s4h3.12 |
Van-der-waals | C-term | N | 860 | - | G.s4h3 | N | 248 | G.s4h3.12 |
Hydrophobic | H8 | R | 829 | 8x54 | G.H4 | L | 333 | G.H4.16 |
Hydrophobic | TM6 | F | 756 | 6x33 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | P | 671 | - | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 671 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | A | 668 | - | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | A | 668 | - | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | C-term | C | 859 | - | G.s4h3 | V | 243 | G.s4h3.07 |
Van-der-waals | C-term | C | 859 | - | G.s4h3 | V | 243 | G.s4h3.07 |
Hydrophobic | TM3 | F | 661 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | F | 661 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Ionic | C-term | E | 863 | - | G.s4h3 | R | 245 | G.s4h3.09 |
Polar | C-term | E | 863 | - | G.s4h3 | R | 245 | G.s4h3.09 |
Hydrophobic | C-term | E | 863 | - | G.s4h3 | R | 245 | G.s4h3.09 |
Van-der-waals | C-term | E | 863 | - | G.s4h3 | R | 245 | G.s4h3.09 |
Hydrophobic | ICL2 | A | 664 | - | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | A | 664 | - | G.H5 | R | 367 | G.H5.12 |
Polar | ICL2 | R | 670 | - | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL2 | R | 670 | - | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | ICL2 | R | 670 | - | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | C-term | E | 863 | - | H.hdhe | Q | 157 | H.hdhe.02 |
Hydrophobic | C-term | V | 858 | - | G.hgh4 | Y | 298 | G.hgh4.01 |
Aromatic | C-term | F | 835 | - | G.H4 | R | 334 | G.H4.17 |
Hydrophobic | C-term | F | 835 | - | G.H4 | R | 334 | G.H4.17 |
Van-der-waals | C-term | F | 835 | - | G.H4 | R | 334 | G.H4.17 |
Hydrophobic | C-term | V | 858 | - | G.s4h3 | M | 242 | G.s4h3.06 |
Van-der-waals | C-term | V | 858 | - | G.s4h3 | M | 242 | G.s4h3.06 |
Hydrophobic | C-term | R | 834 | - | G.hgh4 | P | 308 | G.hgh4.11 |
Van-der-waals | C-term | R | 834 | - | G.hgh4 | P | 308 | G.hgh4.11 |
Hydrophobic | H8 | V | 826 | 8x51 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | H8 | V | 826 | 8x51 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | H8 | V | 826 | 8x51 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM4 | P | 676 | 4x29 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM4 | P | 676 | 4x29 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | H8 | P | 831 | 8x56 | G.h4s6 | T | 337 | G.h4s6.03 |
Polar | ICL1 | K | 599 | 12x51 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL1 | K | 599 | 12x51 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | ICL1 | K | 599 | 12x51 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | A | 830 | 8x55 | G.h4s6 | T | 337 | G.h4s6.03 |
Polar | H8 | H | 828 | 8x53 | G.h4s6 | Y | 345 | G.h4s6.20 |
Aromatic | H8 | H | 828 | 8x53 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | H8 | H | 828 | 8x53 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | H8 | H | 828 | 8x53 | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM3 | I | 660 | 3x57 | G.H5 | L | 380 | G.H5.25 |