Gz -
mGlu2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | G | 861 | - | G.h1ha | G | 59 | G.h1ha.02 |
Hydrophobic | C-term | G | 861 | - | G.h1ha | G | 59 | G.h1ha.02 |
Van-der-waals | C-term | G | 861 | - | G.h1ha | G | 59 | G.h1ha.02 |
Polar | ICL2 | Q | 669 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 669 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 669 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | C-term | C | 859 | - | G.h1ha | F | 61 | G.h1ha.04 |
Van-der-waals | C-term | C | 859 | - | G.h1ha | F | 61 | G.h1ha.04 |
Ionic | H8 | H | 828 | 8x53 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | H8 | H | 828 | 8x53 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | H8 | H | 828 | 8x53 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | H8 | H | 828 | 8x53 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | C-term | C | 859 | - | H.HA | L | 63 | H.HA.01 |
Hydrophobic | ICL2 | E | 666 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | E | 666 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | A | 668 | - | G.S1 | I | 34 | G.S1.02 |
Hydrophobic | C-term | C | 859 | - | H.hehf | I | 169 | H.hehf.05 |
Polar | C-term | C | 859 | - | H.hehf | P | 170 | H.hehf.06 |
Van-der-waals | C-term | C | 859 | - | H.hehf | P | 170 | H.hehf.06 |
Polar | C-term | C | 859 | - | H.HA | C | 66 | H.HA.04 |
Hydrophobic | C-term | C | 859 | - | H.HA | C | 66 | H.HA.04 |
Van-der-waals | C-term | C | 859 | - | H.HA | C | 66 | H.HA.04 |
Polar | ICL2 | A | 668 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | A | 668 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | A | 668 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | C-term | C | 859 | - | G.h1ha | N | 62 | G.h1ha.05 |
Van-der-waals | C-term | C | 859 | - | G.h1ha | N | 62 | G.h1ha.05 |
Hydrophobic | C-term | G | 861 | - | G.h1ha | G | 60 | G.h1ha.03 |
Hydrophobic | TM3 | F | 661 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | F | 661 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | ICL2 | E | 666 | - | G.HN | Q | 28 | G.HN.52 |
Ionic | ICL2 | E | 666 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | E | 666 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | E | 666 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | E | 666 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | P | 753 | - | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | G | 861 | - | G.h1ha | N | 62 | G.h1ha.05 |
Hydrophobic | TM2 | G | 602 | 2x35 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | G | 667 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | G | 667 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | G | 667 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM6 | F | 756 | 6x33 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM6 | F | 756 | 6x33 | G.H5 | I | 345 | G.H5.16 |
Polar | C-term | T | 857 | - | H.HF | V | 172 | H.HF.01 |
Polar | ICL2 | R | 670 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Hydrophobic | ICL2 | R | 670 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Van-der-waals | ICL2 | R | 670 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Hydrophobic | ICL2 | A | 664 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | A | 664 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | G | 667 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM3 | I | 660 | 3x57 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | I | 660 | 3x57 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | I | 660 | 3x57 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | I | 660 | 3x57 | G.H5 | L | 349 | G.H5.20 |
Polar | TM3 | R | 656 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 656 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 656 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | C-term | F | 835 | - | G.H4 | Y | 297 | G.H4.03 |
Polar | H8 | R | 829 | 8x54 | G.H5 | A | 339 | G.H5.10 |
Hydrophobic | H8 | R | 829 | 8x54 | G.H5 | A | 339 | G.H5.10 |
Van-der-waals | H8 | R | 829 | 8x54 | G.H5 | A | 339 | G.H5.10 |
Ionic | H8 | R | 829 | 8x54 | G.H5 | D | 342 | G.H5.13 |
Polar | H8 | R | 829 | 8x54 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | H8 | R | 829 | 8x54 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | H8 | R | 829 | 8x54 | G.H5 | D | 342 | G.H5.13 |
Polar | C-term | N | 860 | - | G.h1ha | F | 61 | G.h1ha.04 |
Polar | TM2 | G | 602 | 2x35 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM2 | G | 602 | 2x35 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM2 | G | 602 | 2x35 | G.H5 | G | 353 | G.H5.24 |
Polar | C-term | G | 861 | - | G.h1ha | F | 61 | G.h1ha.04 |
Hydrophobic | C-term | G | 861 | - | G.h1ha | F | 61 | G.h1ha.04 |
Van-der-waals | C-term | G | 861 | - | G.h1ha | F | 61 | G.h1ha.04 |
Hydrophobic | ICL2 | R | 665 | - | G.S3 | L | 195 | G.S3.01 |
Polar | ICL1 | K | 599 | 12x51 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL1 | K | 599 | 12x51 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL1 | K | 599 | 12x51 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | ICL1 | K | 599 | 12x51 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | ICL1 | K | 599 | 12x51 | G.H5 | C | 355 | G.H5.26 |
Ionic | TM5 | K | 751 | 5x63 | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | TM5 | K | 751 | 5x63 | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | TM5 | K | 751 | 5x63 | G.s2s3 | E | 194 | G.s2s3.02 |
Van-der-waals | TM5 | K | 751 | 5x63 | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | C-term | P | 856 | - | H.hehf | T | 171 | H.hehf.07 |
Hydrophobic | TM6 | F | 756 | 6x33 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | F | 756 | 6x33 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM3 | F | 661 | 3x58 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM3 | F | 661 | 3x58 | G.H5 | I | 345 | G.H5.16 |
Polar | ICL3 | N | 755 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL3 | N | 755 | - | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | ICL3 | N | 755 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL2 | A | 664 | - | G.S1 | I | 34 | G.S1.02 |
Polar | ICL2 | R | 665 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | R | 665 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 665 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL1 | A | 600 | 12x52 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | ICL1 | A | 600 | 12x52 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | ICL1 | K | 599 | 12x51 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM3 | I | 657 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | I | 674 | - | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | ICL2 | I | 674 | - | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL1 | S | 601 | 12x53 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | ICL1 | S | 601 | 12x53 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | C-term | N | 860 | - | G.h1ha | G | 59 | G.h1ha.02 |
Ionic | ICL2 | R | 665 | - | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | ICL2 | R | 665 | - | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 665 | - | G.s2s3 | E | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 665 | - | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | TM4 | P | 676 | 4x29 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM6 | F | 756 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | F | 756 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | E | 758 | 6x35 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | I | 660 | 3x57 | G.H5 | L | 354 | G.H5.25 |
Polar | TM3 | R | 656 | 3x53 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM3 | R | 656 | 3x53 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM3 | R | 656 | 3x53 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | C-term | V | 864 | - | G.h1ha | G | 59 | G.h1ha.02 |
Hydrophobic | ICL2 | A | 668 | - | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | A | 668 | - | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | ICL1 | A | 600 | 12x52 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | ICL1 | A | 600 | 12x52 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM3 | R | 656 | 3x53 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | R | 670 | - | G.H5 | Y | 351 | G.H5.22 |
Aromatic | ICL2 | R | 670 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | ICL2 | R | 670 | - | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | ICL2 | R | 670 | - | G.H5 | Y | 351 | G.H5.22 |